Absolute quantification of myocardial perfusion under adenosine stress.

Abstract:

:The prebolus technique allows one to quantify perfusion in the human heart with a low variability by means of MRI. In this study the prebolus technique was used to determine quantitative perfusion values in the human heart under adenosine stress and to measure the myocardial perfusion reserve (MPR). Twelve healthy volunteers were examined using the multislice prebolus technique with 1/4 cc Gd-BOPTA. Signal intensity (SI) time courses were evaluated in 288 manually segmented sectors at rest and stress. Myocardial perfusion was determined by deconvolution of the SI time courses with the arterial input function (AIF) from the prebolus scan. The mean stress perfusion value was 1.78 +/- 0.53 cc/g/min, and the mean rest perfusion was 0.52 +/- 0.11 cc/g/min, resulting in a mean MPR of 3.59 +/- 1.26. The measured values correlate well with data from animal models and human positron emission tomography (PET) studies.

journal_name

Magn Reson Med

authors

Ritter C,Brackertz A,Sandstede J,Beer M,Hahn D,Köstler H

doi

10.1002/mrm.21020

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

844-9

issue

4

eissn

0740-3194

issn

1522-2594

journal_volume

56

pub_type

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