Abstract:
:Dynamic MRI tracking of rat T-cells in vivo is performed in rat testicles after labeling isolated rat T-cells in vitro with superparamagnetic dextran-coated iron-oxide particles, BMS180549. Tissue inflammation induced by the local injection of the calcium ionophore, A23187, is used to attract labeled T-cells. Gradient-echo MR images of rat testicles show a statistically significant decrease (4%) of the signal intensity in areas of injection of A23187 as early as 30 min after intravenous infusion of 2 x 10(8) labeled T-cells. The signal change reaches its maximum (6-7% decrease) at about 60-120 min after cell infusion. T2-mapping also shows a decrease of T2 in the areas with A23187. Image quantitation, which includes a chemical-shift effect, significantly enhances the sensitivity for detection of superparamagnetically labeled T-cells. Localization of labeled T-cells in rat testicles has been verified by fluorescence microscopy studies of T-cells co-labeled with a lipophilic fluorescent carbocyanine dye, 1,1-dioctadecyl-3,3,3',3'-tetramethyl-lindocarbocyanine perchlorate. These results represent the first successful demonstration of dynamic tracking of specific cells in vivo using MRI.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Yeh TC,Zhang W,Ildstad ST,Ho Cdoi
10.1002/mrm.1910330209subject
Has Abstractpub_date
1995-02-01 00:00:00pages
200-8issue
2eissn
0740-3194issn
1522-2594journal_volume
33pub_type
杂志文章abstract::A proton NMR relaxation and pulsed field gradient self-diffusion study of water in fibrin gels, plasma, and blood clots has been performed with special emphasis on the effect of the sol-gel and shrinkage transitions. Deuteron NMR in fibrin gels was also studied to supplement the proton data. It is shown that a measure...
journal_title:Magnetic resonance in medicine
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abstract:PURPOSE:To assess the use of image registration for correcting respiratory motion in free breathing lung T1 mapping acquisition in patients with idiopathic pulmonary fibrosis (IPF). THEORY AND METHODS:The method presented used image registration to synthetic images during postprocessing to remove respiratory motion. S...
journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910330407
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abstract:PURPOSE:A multi-turn transmit surface coil design was presented to improve B1 efficiency when used with current source amplification. METHODS:Three different coil designs driven by an on-coil current-mode class-D amplifier with current envelope feedback were tested on the benchtop and through imaging in a 1.5 T scanne...
journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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更新日期:2006-12-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2010-05-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910340328
更新日期:1995-09-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.20299
更新日期:2004-12-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2017-07-01 00:00:00
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doi:10.1002/mrm.1146
更新日期:2001-06-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21255
更新日期:2007-07-01 00:00:00
abstract::Quantitative diffusion measurements were performed in tumors arising from inoculation of nude mice with two human breast cancer cell lines (MCF7 and T47D) to evaluate the specificity of this technique for characterizing solid tumors. ADC maps were compared to histology and correlated well with gross tumor morphology. ...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910370417
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journal_title:Magnetic resonance in medicine
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更新日期:2016-06-01 00:00:00
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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更新日期:2012-10-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199908)42:2<345::aid-mrm17
更新日期:1999-08-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2008-06-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910390614
更新日期:1998-06-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2013-01-01 00:00:00
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更新日期:2003-09-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:1994-11-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2018-01-01 00:00:00