Volumetric analysis of white matter, gray matter, and CSF using fractional volume analysis.

Abstract:

:Quantitative cerebral tissue volumes may be useful for an objective assessment of pathological changes in brain. Accurate determination of tissue volumes is complicated, however, by the partial volume averaging (PVA) effect. We have, therefore, developed a new pulse sequence that minimizes the PVA through the use of inversion-recovery (IR) and double inversion-recovery (DIR) techniques. This pulse sequence simultaneously acquires four different sets of images to provide the necessary information for volumetric analysis and reduces potential spatial misregistration of images due to patient motion. The image sets acquired from the proposed pulse sequence are 1) gray matter visible, 2) white matter visible, 3) FLAIR, and 4) fast spin-echo proton-density weighted images. An algorithm has been implemented to correct for differential T1-weighting and for tissue quantitation.

journal_name

Magn Reson Med

authors

Bedell BJ,Narayana PA

doi

10.1002/mrm.1910390614

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

961-9

issue

6

eissn

0740-3194

issn

1522-2594

journal_volume

39

pub_type

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