Abstract:
:Magnetization transfer imaging (MT) and localized proton spectroscopy (1H-MRS) were utilized in the evaluation of lesions (high signal abnormalities on T2-weighted images) and normal-appearing white matter (NAWM) in multiple sclerosis (MS). Eleven patients with a clinical diagnosis of MS were independently evaluated with both 1H-MRS and MT. The magnetization transfer ratio (MTR) of lesions was compared with the relative concentration of N-acetyl-aspartate (NAA) and a composite peak at 2.1 to 2.6 ppm termed "marker peaks." The MTR of white matter lesions in the MS patients was markedly decreased (6-34%; normal approximately 42%), and correlated well with increase in the marker peaks region (0.94-3.89). There was no correlation between the relative concentration of NAA and MTR. Increased resonance peaks in the 2.1 to 2.6 ppm range and marked decreases in MTR may be a relatively specific indicators of demyelination.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Hiehle JF Jr,Lenkinski RE,Grossman RI,Dousset V,Ramer KN,Schnall MD,Cohen JA,Gonzalez-Scarano Fdoi
10.1002/mrm.1910320303subject
Has Abstractpub_date
1994-09-01 00:00:00pages
285-93issue
3eissn
0740-3194issn
1522-2594journal_volume
32pub_type
杂志文章abstract:PURPOSE:Evaluate the usefulness of single-shot and of interleaved spatiotemporally encoded (SPEN) methods to perform diffusion tensor imaging (DTI) under various preclinical and clinical settings. METHODS:A formalism for analyzing SPEN DTI data is presented, tailored to account for the spatially dependent b-matrix wei...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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abstract::Traditionally, the method of nonlinear least squares (NLLS) analysis has been used to estimate the parameters obtained from exponential decay data. In this study, we evaluated the use of Bayesian probability theory to analyze such data; specifically, that resulting from intravoxel incoherent motion NMR experiments. An...
journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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更新日期:2013-04-01 00:00:00
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更新日期:2009-10-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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更新日期:2004-08-01 00:00:00
abstract::Accurate and reproducible MRI R2 * relaxometry for tissue iron quantification is important in managing transfusion-dependent patients. MRI data are often acquired using array coils and reconstructed by the root-sum-square algorithm, and as such, measured signals follow the noncentral chi distribution. In this study, t...
journal_title:Magnetic resonance in medicine
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更新日期:2013-12-01 00:00:00
abstract:PURPOSE:Quantitative mapping of the native T1 of the heart using the modified look-locker inversion recovery (MOLLI) technique provides high quality diagnostic information without requiring contrast agents. Previous work has considered the effects of T2 relaxation on MOLLI T1 measurements, finding that the T1 measured ...
journal_title:Magnetic resonance in medicine
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更新日期:2013-09-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:1989-06-01 00:00:00
abstract::A modified Prony method (MPM) was applied to analyze the main signals present in spatially resolved 31P NMR spectra of MCF7 breast tumors implanted in nude mice. First, the method was tested on synthetic data to establish its limits of reliability. Its performance with respect to peak identification and quantification...
journal_title:Magnetic resonance in medicine
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更新日期:1997-08-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:1999-02-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2009-03-01 00:00:00
abstract:PURPOSE:To develop and validate a data processing technique that allows phase-contrast MRI-based 4D flow imaging of the aortic valve in a single breath-hold. THEORY AND METHODS:To regularize the ill-posed inverse problem, we extend a recently proposed 2D phase-contrast MRI method to 4D flow imaging. Adopting an empiri...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27386
更新日期:2019-02-01 00:00:00
abstract::The incoherent displacement of water in living tissues is of considerable interest because of the widespread use of diffusion-weighted MRI, for which image contrast is based on the water apparent diffusion coefficient (ADC). It has been hypothesized that the decrease in water ADC associated with brain injury is primar...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10181
更新日期:2002-07-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910140215
更新日期:1990-05-01 00:00:00
abstract::Lactate is a key metabolite and its rates of cellular uptake and release, its production rates from glucose and glycogen, and its interconversion rate with pyruvate are important determinants of cellular energy production. If lactate precursors such as pyruvate and glucose are labeled appropriately with (13)C, (1)H NM...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.20075
更新日期:2004-06-01 00:00:00
abstract::Ferumoxytol is an ultrasmall superparamagnetic iron oxide agent marketed for the treatment of anemia. There has been increasing interest in its properties as an MRI contrast agent as well as greater awareness of its adverse event profile. This mini-review summarizes the current state of knowledge of the risks of ferum...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章,评审
doi:10.1002/mrm.26151
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:To develop a fast and accurate method for 3D T2 mapping of prostate cancer using undersampled acquisition and dictionary-based fitting. METHODS:3D high-resolution T2 -weighted images (0.9 × 0.9 × 3 mm3 ) were obtained with a multishot T2 -prepared balanced steady-state free precession (T2 -prep-bSSFP) acquisit...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27540
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:To study the utility of fractional calculus in modeling gradient-recalled echo MRI signal decay in the normal human brain. METHODS:We solved analytically the extended time-fractional Bloch equations resulting in five model parameters, namely, the amplitude, relaxation rate, order of the time-fractional derivat...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26222
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:The purpose of this work was to develop and evaluate a robust water-fat separation method for T1-weighted symmetric two-point Dixon data. THEORY AND METHODS:A method for water-fat separation by phase unwrapping of the opposite-phase images by phase-sensitive reconstruction (PSR) is introduced. PSR consists of ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26488
更新日期:2017-09-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2001-10-01 00:00:00
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更新日期:2015-09-01 00:00:00
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更新日期:2017-12-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 临床试验,杂志文章
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更新日期:2012-11-01 00:00:00
abstract::An eight-channel receive-only brain coil and table-top detunable volume transmit coil were developed and tested at 7 T for human imaging. Optimization of this device required attention to sources of interaction between the array elements, between the transmit and receive coils and minimization of common mode currents ...
journal_title:Magnetic resonance in medicine
pub_type: 临床试验,杂志文章
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更新日期:2005-07-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2020-11-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25510
更新日期:2015-11-01 00:00:00
abstract::Experimental procedures for obtaining localized 31P NMR spectra of humans by means of the ISIS sequence are discussed in detail. The technique is optimized for use with volume coils and with surface coils in order to measure localized 31P NMR spectra of different tissues and organs. Selective frequency-modulated (FM) ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910110102
更新日期:1989-07-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2008-07-01 00:00:00
abstract::A method is suggested whereby the shifted extracellular triple quantum filtered 23Na signal of an isolated organ is completely eliminated. The method is based on the long relaxation time of the triple quantum coherence and on its fast evolution rate. When the carrier frequency is set on top of the intracellular sodium...
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更新日期:1993-10-01 00:00:00