Correlation of spectroscopy and magnetization transfer imaging in the evaluation of demyelinating lesions and normal appearing white matter in multiple sclerosis.

Abstract:

:Magnetization transfer imaging (MT) and localized proton spectroscopy (1H-MRS) were utilized in the evaluation of lesions (high signal abnormalities on T2-weighted images) and normal-appearing white matter (NAWM) in multiple sclerosis (MS). Eleven patients with a clinical diagnosis of MS were independently evaluated with both 1H-MRS and MT. The magnetization transfer ratio (MTR) of lesions was compared with the relative concentration of N-acetyl-aspartate (NAA) and a composite peak at 2.1 to 2.6 ppm termed "marker peaks." The MTR of white matter lesions in the MS patients was markedly decreased (6-34%; normal approximately 42%), and correlated well with increase in the marker peaks region (0.94-3.89). There was no correlation between the relative concentration of NAA and MTR. Increased resonance peaks in the 2.1 to 2.6 ppm range and marked decreases in MTR may be a relatively specific indicators of demyelination.

journal_name

Magn Reson Med

authors

Hiehle JF Jr,Lenkinski RE,Grossman RI,Dousset V,Ramer KN,Schnall MD,Cohen JA,Gonzalez-Scarano F

doi

10.1002/mrm.1910320303

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

285-93

issue

3

eissn

0740-3194

issn

1522-2594

journal_volume

32

pub_type

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