Abstract:
PURPOSE:To study the utility of fractional calculus in modeling gradient-recalled echo MRI signal decay in the normal human brain. METHODS:We solved analytically the extended time-fractional Bloch equations resulting in five model parameters, namely, the amplitude, relaxation rate, order of the time-fractional derivative, frequency shift, and constant offset. Voxel-level temporal fitting of the MRI signal was performed using the classical monoexponential model, a previously developed anomalous relaxation model, and using our extended time-fractional relaxation model. Nine brain regions segmented from multiple echo gradient-recalled echo 7 Tesla MRI data acquired from five participants were then used to investigate the characteristics of the extended time-fractional model parameters. RESULTS:We found that the extended time-fractional model is able to fit the experimental data with smaller mean squared error than the classical monoexponential relaxation model and the anomalous relaxation model, which do not account for frequency shift. CONCLUSIONS:We were able to fit multiple echo time MRI data with high accuracy using the developed model. Parameters of the model likely capture information on microstructural and susceptibility-induced changes in the human brain. Magn Reson Med 77:1485-1494, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Qin S,Liu F,Turner IW,Yu Q,Yang Q,Vegh Vdoi
10.1002/mrm.26222subject
Has Abstractpub_date
2017-04-01 00:00:00pages
1485-1494issue
4eissn
0740-3194issn
1522-2594journal_volume
77pub_type
杂志文章abstract::Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl to the exposed rat cortex. MEMRI signal increase in the ipsilateral cortex relative to the contralateral control region was 60 +/- 30% following two KCl applications. MEMRI signal increase for a...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20438
更新日期:2005-04-01 00:00:00
abstract::A method is presented that employs the inherent spectral selectivity of the Steady-State Free Precession (SSFP) pulse sequence to provide a spectral band of suppression. At TE = TR/2, SSFP partitions the magnetization into two phase-opposed spectral components. Z-storing one of these components simultaneously further ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20633
更新日期:2005-10-01 00:00:00
abstract::Dextran-magnetite, a superparamagnetic compound, is a powerful relaxation reagent for sodium. Administered intravenously, it is confined mainly to the vasculature and eliminates the signal from plasma sodium, a significant component of the tissue sodium signal. Applications of dextran-magnetite for in vivo sodium imag...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910080406
更新日期:1988-12-01 00:00:00
abstract::The purpose of this work was to implement autocalibrating GRAPPA-based parallel imaging (PI) for in vivo high-resolution (HR) MRI of cartilage and trabecular bone micro-architecture at 7T and to evaluate its performance based on comparison of MR-derived morphology metrics between accelerated and conventional images an...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21455
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:To demonstrate how triple diffusion encoding (TDE) MRI can be applied to separately estimate the intra-axonal and extra-axonal diffusion tensors in white matter (WM). METHODS:Using a TDE pulse sequence with an axially symmetric b-matrix, diffusion MRI data were acquired at 3T for 3 healthy adults with an axial...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28084
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:To develop a fully automated trajectory and gradient waveform design for the non-Cartesian shells acquisition, and to develop a magnetization-prepared (MP) shells acquisition to achieve an efficient three-dimensional acquisition with improved gray-to-white brain matter contrast. METHODS:After reviewing the she...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26863
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:Sensitivity encoding (SENSE) reconstruction of multiband echo planar imaging (EPI) may cause artifacts when simultaneously excited slices require different phase correction to remove the EPI-specific ghost shifted by half of the matrix size (N). We propose a simplified solution of this problem that combines SEN...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25915
更新日期:2016-09-01 00:00:00
abstract::The behavior of the lithium (Li) ion in normal human erythrocytes has been studied by 7Li NMR. The uptake of Li into the cells was followed as a function of solution conditions, temperature, hematocrit, and blood age using dysprosium tripolyphosphate shift reagent. Under our conditions the uptake of Li increases with ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910200207
更新日期:1991-08-01 00:00:00
abstract:PURPOSE:Respiratory motion makes hepatic ablation using high intensity focused ultrasound (HIFO) challenging. Previous HIFU liver treatment had required apnea induced during general anesthesia. We describe and test a system that allows treatment of the liver in the presence of breathing motion. METHODS:Mapping a signa...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24695
更新日期:2014-02-01 00:00:00
abstract::Skeletal muscle triglycerides are markers for insulin resistance in type 2 diabetes. Recently, MR spectroscopy was adapted for in vivo measurement of triglycerides in animal models and for the characterization of new therapeutic approaches. Because of small MR spectroscopy voxel sizes used in skeletal muscles, surface...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22149
更新日期:2009-10-01 00:00:00
abstract:PURPOSE:To develop a flexible fast spin echo (FSE) triple-echo Dixon (FTED) technique. METHODS:An FSE pulse sequence was modified by replacing each readout gradient with three fast-switching bipolar readout gradients with minimal interecho dead time. The corresponding three echoes were used to generate three raw image...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26186
更新日期:2017-03-01 00:00:00
abstract::Phase-contrast magnetic resonance imaging is subject to numerous sources of error, which decrease clinical confidence in the reported measures. This work outlines how stationary perivascular fat can impart a significant chemical shift induced phase-contrast magnetic resonance imaging measurement error using computatio...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24262
更新日期:2013-02-01 00:00:00
abstract::Proton-observed carbon-edited (POCE) NMR spectroscopy is commonly used to measure 13C labeling with higher sensitivity compared to direct 13C NMR spectroscopy, at the expense of spectral resolution. For weakly coupled first-order spin systems, the multiplet signal at a specific proton chemical shift in POCE spectra di...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20764
更新日期:2006-02-01 00:00:00
abstract:PURPOSE:A ghost correction strategy for Simultaneous Multi-Slice (SMS) EPI methods that provides improved ghosting artifact reduction compared to conventional methods is presented. Conventional Nyquist ghost correction methods for SMS-EPI rely on navigator data that contain phase errors from all slices in the simultane...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27113
更新日期:2018-10-01 00:00:00
abstract::The application of spectroscopy techniques to the study of normal and pathological tissue is currently limited by the difficulties of acquiring precisely localized spectra and analyzing the resulting, relatively low signal-to-noise data. Interpretation of multivoxel spectroscopy data is greatly facilitated by estimati...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910250109
更新日期:1992-05-01 00:00:00
abstract::To date, most functional imaging centers have relied on ultrafast imaging approaches such as echo-planar imaging (EPI) techniques for acquiring functional brain activation data. These methods require specialized hardware and are not yet installed widely on clinical MR imagers, thus limiting the application of function...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910380417
更新日期:1997-10-01 00:00:00
abstract::In vivo measurements of gadodiamide (Gd-DTPA-BMA) T(1) relaxivity were performed at 4.7 T in injured and normal rat brains. Cerebral lesions were induced in nine rats by a localized freezing method. T(1) maps of the lesions were generated before and after injection of Gd-DTPA-BMA (0.1-0.6 mmol/kg). Samples of normal a...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20336
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To obtain three-dimensional (3D) MR angiography having high contrast between vessel and stationary background tissue, a novel technique called sliding time of flight (TOF) is proposed. METHODS:The proposed method relies on the property that flow-related enhancement (FRE) is maximized at the blood-entering slic...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25215
更新日期:2015-03-01 00:00:00
abstract::The protocol for delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was adapted for the evaluation of transplanted osteochondral allograft cartilage. Eight patients with focal grade 4 cartilage defects of the femoral condyle were treated with single cylindrical osteochondral allografts. At 1 and 2 years, dGEMRIC i...
journal_title:Magnetic resonance in medicine
pub_type: 临床试验,杂志文章
doi:10.1002/mrm.24419
更新日期:2013-06-01 00:00:00
abstract::Accurate quantification of myocardial perfusion remains challenging due to saturation of the arterial input function at high contrast concentrations. A method for estimating the arterial input function directly from tissue curves in the myocardium that avoids these difficulties is presented. In this constrained altern...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22809
更新日期:2011-08-01 00:00:00
abstract::Reduction of image-to-image signal fluctuations and imaging artifacts is important for fMRI studies. The imaging artifacts caused by respiration, cardiac pulsation, and gross head motion and the suppression of these artifacts have been studied for many years. However, the artifacts caused by eye movement and their eff...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910380407
更新日期:1997-10-01 00:00:00
abstract::An electron paramagnetic resonance image was measured for the first time from in vivo field gradient spectra of a living murine tumor (Cloudman S-91 melanoma in the tail of a DBA-2J mouse) using the paramagnetic nitroxide imaging agent 3-carboxamido-2,2,5,5-tetramethylpyrroline-1-oxyl injected into the tail vein. The ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910040410
更新日期:1987-04-01 00:00:00
abstract::In the ongoing quest for faster imaging and higher spatial resolution, several methods have been developed to speed up data acquisition by incorporating prior information about the object being imaged. This study shows that many of these methods can be integrated into a single common equation. The unified framework pr...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1242
更新日期:2001-10-01 00:00:00
abstract:PURPOSE:To demonstrate the feasibility of imaging a bolus of co-polarized [1-13 C]pyruvate and 13 C-urea to simultaneously assess both metabolism and perfusion in the rodent heart. METHODS:Copolarized [1-13 C]pyruvate and 13 C-urea was imaged using a multi-echo, flow-sensitized spiral pulse sequence. Healthy rats were...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26106
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:The objective of this study was to determine whether a sodium phased array would improve sodium breast MRI at 3 T. The secondary objective was to create acceptable proton images with the sodium phased array in place. METHODS:A novel composite array for combined proton/sodium 3 T breast MRI is compared with a c...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24860
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:To investigate four-dimensional flow denoising using the divergence-free wavelet (DFW) transform and compare its performance with existing techniques. THEORY AND METHODS:DFW is a vector-wavelet that provides a sparse representation of flow in a generally divergence-free field and can be used to enforce "soft" ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25176
更新日期:2015-02-01 00:00:00
abstract::A double-tuned single coil probe for high field metabolic NMR studies has been designed and tested. The resonant coil is a single-turn of copper foil wound on a quartz cylinder. It is fed by a short length of parallel strip line made of the same material; the feeder is also used as a tuning capacitance. Electrical par...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910230216
更新日期:1992-02-01 00:00:00
abstract::The MMQ cell line is a unique prolactin-secreting rat pituitary cell line. MMQ cells entrapped in agarose gel threads are metabolically active, as determined by the uptake and phosphorylation of creatine and the maintenance of high energy phosphates for over 15 h. Forskolin activates the catalytic subunit of adenylyl ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910320507
更新日期:1994-11-01 00:00:00
abstract:PURPOSE:Parameter mapping in sodium MRI data is challenging due to inherently low SNR and spatial resolution, prompting the need to employ robust models and estimation techniques. This work aims to develop a continuum model of sodium T 2 ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27659
更新日期:2019-06-01 00:00:00
abstract::Some of the factors involved in the choice of field strength for NMR imaging are examined. The influences of relaxation times and chemical shift upon image quality and signal-to-noise ratio are highlighted, and power deposition is introduced as a significant factor which may limit the flexibility and information avail...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910030509
更新日期:1986-10-01 00:00:00