Abstract:
:The preovulatory rat follicle reaches a diameter of 1 mm with no internal blood vessels. Nutrient supply to the enclosed oocyte depends solely on passive diffusion across the follicular wall and the follicular fluid. Spin-echo and stimulated-echo NMR microscopy experiments were applied here for studying modulations in water diffusion during gonadotropin-induced maturation of perfused rat ovarian follicles (32 degrees C). Two diffusion compartments were observed for the follicular wall. The intracellular water diffusion coefficient, measured at a short diffusion time (9 ms) was 0.28 x 10(-5) cm2/s. Diffusion at long diffusion times was restricted to 16 microns, the size of cells in the follicular wall, and did not change during maturation. In the follicular fluid a transient 26% decrease in the diffusion coefficient was observed 4-7 h after gonadotropin stimulation, a change that is bound to affect the metabolic balance of the oocyte before ovulation.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Tempel C,Schiffenbauer YS,Meir G,Neeman Mdoi
10.1002/mrm.1910340212subject
Has Abstractpub_date
1995-08-01 00:00:00pages
213-8issue
2eissn
0740-3194issn
1522-2594journal_volume
34pub_type
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