Abstract:
:Developing a method to noninvasively monitor tissue-engineered constructs is critical for the optimization of construct design and for assessing therapeutic efficacy. For this purpose, NMR is a powerful technique that can be used to obtain both images and spectroscopic data. But the inherent sensitivity of NMR limits the observation of a bioartificial construct with current NMR surface coil technology. In this study, we address this limitation through the development of an inductively coupled, implantable coil system, demonstrate its use at high field (11.1 T), and investigate the use of this coil system for monitoring a bioartificial construct in vitro and in vivo. The results establish that large gains in signal to noise can be obtained with this coil system over that obtainable with a surface coil. This coil system provides a means to quantitatively analyze the structure and function of implanted bioartificial organs.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Volland NA,Mareci TH,Constantinidis I,Simpson NEdoi
10.1002/mrm.22268subject
Has Abstractpub_date
2010-04-01 00:00:00pages
998-1006issue
4eissn
0740-3194issn
1522-2594journal_volume
63pub_type
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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