Hypercarbia-induced changes in cerebral blood volume in the cat: a 1H MRI and intravascular contrast agent study.

Abstract:

:Cerebral blood volume changes with arterial carbon dioxide were monitored by proton T1-weighted MR images following administration of the intravascular contrast agent Gd-DTPA labeled with human serum albumin. Without MR contrast, no significant image intensity changes were observed with PaCO2. Following contrast, regional brain image intensities increased significantly over control (0% inspired CO2) in cortical gray, white, and basal ganglia regions with increasing PaCO2 and returned to control intensities upon return to 0% inspired CO2. Imaging of through-plane and in-plane phantoms was performed to assess flow effects. Signal losses of 2 and 6% (relative to no flow) were observed for bulk velocities of 5 mm/s at TE values of 15 ms. An intravascular contrast agent may be useful for MRI monitoring of local cerebral blood volume changes during cerebral perturbations.

journal_name

Magn Reson Med

authors

Moseley ME,Chew WM,White DL,Kucharczyk J,Litt L,Derugin N,Dupon J,Brasch RC,Norman D

doi

10.1002/mrm.1910230104

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

21-30

issue

1

eissn

0740-3194

issn

1522-2594

journal_volume

23

pub_type

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