Broadband proton decoupling for in vivo brain spectroscopy in humans.

Abstract:

:A new decoupling sequence, PBAR, is described for broadband heteronuclear decoupling in vivo in humans at 1.5T. The sequence uses non-adiabatic, frequency- and amplitude-modulated inversion pulses designed to minimize decoupling sidebands at low applied gammaB(2) RF field levels and to cover only the narrow range of resonance offsets encountered in practice. The offset dependence of the decoupling efficiency of PBAR is demonstrated and compared to the conventional WALTZ-4 sequence. At the same average power levels, PBAR had slightly reduced bandwidth but significantly less intense decoupling sidebands. Applications of PBAR are shown in vivo in the human brain both for (31)P and natural abundance (13)C spectroscopy using volume decoupling coils. The PBAR sequence allows whole brain [(1)H]-[13]C decoupling to be performed at 1.5T with a standard head coil within FDA guidelines for RF power deposition. Magn Reson Med 45:226-232, 2001.

journal_name

Magn Reson Med

authors

Barker PB,Golay X,Artemov D,Ouwerkerk R,Smith MA,Shaka AJ

doi

10.1002/1522-2594(200102)45:2<226::aid-mrm1031>3.0

subject

Has Abstract

pub_date

2001-02-01 00:00:00

pages

226-32

issue

2

eissn

0740-3194

issn

1522-2594

pii

10.1002/1522-2594(200102)45:2<226::AID-MRM1031>3.0

journal_volume

45

pub_type

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