Abstract:
:A simple and reliable method for quantifying the fluid content and characterizing the tissue T2 relaxation properties of animal extremities has been devised. This one-dimensional magnetic resonance imaging experiment, applied to the adjuvant arthritis model in rats, provides a useful, noninvasive monitor of the course of the disease in vivo. Tissue is characterized through the analysis of the biexponential T2 decay of the NMR-active hydrogen in the rat leg joint tissue. Long and short T2 components are identified, both of which are sensitive to the arthritic process. The long component is suggested to come from edema and increases by a factor of ca. 9 during the course of the disease, whereas the short T2 component may represent cellular influx into the joint and increases by a factor of ca. 3. These changes correlate with the severity of the disease and can be used to monitor therapeutic response. The main advantage of the technique over the more traditional two-dimensional imaging approach is that only one spatial variable has to be resolved, resulting in shorter imaging time.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Borah B,Szeverenyi NMdoi
10.1002/mrm.1910150208subject
Has Abstractpub_date
1990-08-01 00:00:00pages
246-59issue
2eissn
0740-3194issn
1522-2594journal_volume
15pub_type
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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更新日期:2000-02-01 00:00:00
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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更新日期:2012-09-01 00:00:00
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更新日期:2016-05-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.21034
更新日期:2006-10-01 00:00:00
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更新日期:2004-02-01 00:00:00
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更新日期:2003-05-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:1992-10-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910310109
更新日期:1994-01-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2018-02-01 00:00:00
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更新日期:2008-06-01 00:00:00