Multi-angle ratiometric approach to measure chemical exchange in amide proton transfer imaging.

Abstract:

:Amide proton transfer imaging, a specific form of chemical exchange saturation transfer imaging, has previously been applied to studies of acute ischemic acidosis, stroke, and cancer. However, interpreting the resulting contrast is complicated by its dependence on the exchange rate between amides and water, the amide concentration, amide and water relaxation, and macromolecular magnetization transfer. Hence, conventional chemical exchange saturation transfer contrast is not specific to changes such as reductions in pH due to tissue acidosis. In this article, a multi-angle ratiometric approach based on several pulsed-chemical exchange saturation transfer scans at different irradiation flip angles is proposed to specifically reflect exchange rates only. This separation of exchange effects in pulsed-chemical exchange saturation transfer experiments is based on isolating rotation vs. saturation contributions, and such methods form a new subclass of chemical exchange rotation transfer (CERT) experiments. Simulations and measurements of creatine/agar phantoms indicate that a newly proposed imaging metric isolates the effects of exchange rate changes, independent of other sample parameters.

journal_name

Magn Reson Med

authors

Zu Z,Janve VA,Li K,Does MD,Gore JC,Gochberg DF

doi

10.1002/mrm.23276

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

711-9

issue

3

eissn

0740-3194

issn

1522-2594

journal_volume

68

pub_type

杂志文章
  • Longitudinal assessment of spinal cord injuries in nonhuman primates with quantitative magnetization transfer.

    abstract:PURPOSE:This study aimed to evaluate the reproducibility and specificity of quantitative magnetization transfer (qMT) imaging for monitoring spinal cord injuries (SCIs). METHODS:MRI scans were performed in anesthetized monkeys at 9.4T, before and serially after a unilateral lesion of the cervical spinal cord. A two-po...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25725

    authors: Wang F,Li K,Mishra A,Gochberg D,Min Chen L,Gore JC

    更新日期:2016-04-01 00:00:00

  • 1H and (31)P magnetization transfer studies of hindleg muscle in wild-type and creatine kinase-deficient mice.

    abstract::The authors addressed the hypothesis that interactions with creatine kinase (CK) play a role in the off-resonance magnetization transfer (MT) effect of creatine in skeletal muscle. Toward that aim, (1)H MT studies were done on hindleg muscle in wild-type mice and in transgenic mice, lacking cytoplasmic CK and/or mitoc...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(200005)43:5<657::aid-mrm7>

    authors: Kruiskamp MJ,van Vliet G,Nicolay K

    更新日期:2000-05-01 00:00:00

  • Increasing spoiling efficiency in RF-spoiled gradient echo sequences by averaging of RF phase-cycle-adapted k-spaces.

    abstract::A method is presented that improves the effectiveness of RF-spoiling whenever an image consists of the averaging of several identical single acquisitions. Using this method, it becomes possible to reduce the necessary moment of the spoiler gradient by a factor equal to the number of averages. The idea is to perform th...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22882

    authors: Leupold J,Hennig J

    更新日期:2011-10-01 00:00:00

  • Magnetic resonance imaging of experimental mumps meningoencephalitis in suckling hamsters.

    abstract::Mumps virus-infected and normal newborn hamster brains were imaged with magnetic resonance (MR) within 24 h after birth and serially scanned. Hydrocephalus developed explosively on Day 6 postinfection and progressed until death occurred soon after Day 10. This study demonstrates the utility of MR in the investigation ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910040611

    authors: Narayana PA,Wolinsky JS,Jensen DJ

    更新日期:1987-06-01 00:00:00

  • Determination of the optimal first-order gradient moment for flow-sensitive dephasing magnetization-prepared 3D noncontrast MR angiography.

    abstract::Flow-sensitive dephasing (FSD) magnetization preparation has been developed for black-blood vessel wall MRI and noncontrast MR angiography. The first-order gradient moment, m(1) , is a measure of the flow-sensitization imparted by an FSD preparative module. Determination of the optimal m(1) for each individual is high...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22847

    authors: Fan Z,Zhou X,Bi X,Dharmakumar R,Carr JC,Li D

    更新日期:2011-04-01 00:00:00

  • Multispectral imaging with three-dimensional rosette trajectories.

    abstract::Two-dimensional intersecting k-space trajectories have previously been demonstrated to allow fast multispectral imaging. Repeated sampling of k-space points leads to destructive interference of the signal coming from the off-resonance spectral peaks; on-resonance data reconstruction yields images of the on-resonance p...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21551

    authors: Bucholz EK,Song J,Johnson GA,Hancu I

    更新日期:2008-03-01 00:00:00

  • The dependence of radiofrequency induced pacemaker lead tip heating on the electrical conductivity of the medium at the lead tip.

    abstract::Radiofrequency induced pacemaker lead tip heating is one of the main reasons magnetic resonance imaging (MRI) is contraindicated for patients with pacemakers. The objective of this work was to evaluate the dependence of pacemaker lead tip heating during MRI scanning on the electrical conductivity of the medium surroun...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23235

    authors: Langman DA,Goldberg IB,Judy J,Paul Finn J,Ennis DB

    更新日期:2012-08-01 00:00:00

  • On the overestimation of early wall thickening at the carotid bulb by black blood MRI, with implications for coronary and vulnerable plaque imaging.

    abstract::Black blood MRI is an attractive tool for monitoring normal and pathological wall thickening; however, limited spatial resolutions can conspire with complex vascular geometries to distort the appearance of the wall in ways hitherto unclear. To elucidate this, a thin-walled cylinder model was developed to predict the c...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21758

    authors: Antiga L,Wasserman BA,Steinman DA

    更新日期:2008-11-01 00:00:00

  • "PINOT": time-resolved parallel magnetic resonance imaging with a reduced dynamic field of view.

    abstract::This article introduces a novel method named "Parallel Imaging and Noquist in Tandem" (PINOT) for accelerated image acquisition of cine cardiac magnetic resonance imaging. This method combines two prior information formalisms, the SPACE-RIP implementation of parallel imaging and the Noquist method for reduced-data ima...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22696

    authors: Hamilton LH,Fabregat JA,Moratal D,Ramamurthy S,Lerakis S,Parks WJ,Sallee D 3rd,Brummer ME

    更新日期:2011-04-01 00:00:00

  • Three-dimensional cine imaging using variable-density spiral trajectories and SSFP with application to coronary artery angiography.

    abstract::A single breath-hold 3D cardiac phase resolved steady-state free precession (SSFP) sequence was developed, allowing 3D visualization of the moving coronary arteries. A 3D stack of spirals was acquired continuously throughout the cardiac cycle, and a sliding window reconstruction was used to achieve high temporal resol...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21365

    authors: Kressler B,Spincemaille P,Nguyen TD,Cheng L,Xi Hai Z,Prince MR,Wang Y

    更新日期:2007-09-01 00:00:00

  • Human whole-blood (1)H2O longitudinal relaxation with normal and high-relaxivity contrast reagents: influence of trans-cell-membrane water exchange.

    abstract:PURPOSE:Accurate characterization of contrast reagent (CR) longitudinal relaxivity in whole blood is required to predict arterial signal intensity in contrast-enhanced MR angiography (CE-MRA). This study measured the longitudinal relaxation rate constants (R1 ) over a concentration range for non-protein-binding and pro...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25064

    authors: Wilson GJ,Woods M,Springer CS Jr,Bastawrous S,Bhargava P,Maki JH

    更新日期:2014-12-01 00:00:00

  • Identification of different lipid phases and calcium phosphate deposits in human carotid artery plaques by MAS NMR spectroscopy.

    abstract::Accumulation of lipids in atherosclerotic plaques causes progressive narrowing of the arterial lumen, often followed by thrombosis and ischemia. Currently several different methods, most requiring disruption of the plaque, are used to study the physical properties of lipids accumulated in plaques, and lipid compositio...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910390204

    authors: Guo W,Morrisett JD,Lawrie GM,DeBakey ME,Hamilton JA

    更新日期:1998-02-01 00:00:00

  • Performance evaluation of whole-body NMR scanner antenna systems.

    abstract::Whole-body NMR imaging antennas (probes) are strongly affected by the inevitable magnetic and controllable dielectric losses. Using a convenient parallelepiped model, the magnetic losses are evaluated. By introducing the "ideal power gain," the best possible antenna performance is delimited as a function of the freque...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910020403

    authors: Sergiadis G

    更新日期:1985-08-01 00:00:00

  • T1 measurements in the human myocardium: the effects of magnetization transfer on the SASHA and MOLLI sequences.

    abstract:PURPOSE:Quantitative mapping of the native T1 of the heart using the modified look-locker inversion recovery (MOLLI) technique provides high quality diagnostic information without requiring contrast agents. Previous work has considered the effects of T2 relaxation on MOLLI T1 measurements, finding that the T1 measured ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24867

    authors: Robson MD,Piechnik SK,Tunnicliffe EM,Neubauer S

    更新日期:2013-09-01 00:00:00

  • Pulmonary perfusion: qualitative assessment with dynamic contrast-enhanced MRI using ultra-short TE and inversion recovery turbo FLASH.

    abstract::The accurate assessment of pulmonary perfusion is especially important in the evaluation of patients with suspected pulmonary embolism, a common and potentially lethal disorder that can be treated by aggressive anticoagulation. In this study, we demonstrate for the first time the use of MR to image pulmonary perfusion...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910360402

    authors: Hatabu H,Gaa J,Kim D,Li W,Prasad PV,Edelman RR

    更新日期:1996-10-01 00:00:00

  • Three-dimensional water/fat separation and T2* estimation based on whole-image optimization--application in breathhold liver imaging at 1.5 T.

    abstract::The chemical shift of water and fat resonances in proton MRI allows separation of water and fat signal from chemical shift encoded data. This work describes an automatic method that produces separate water and fat images as well as quantitative maps of fat signal fraction and T2* from complex multiecho gradient-recall...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23185

    authors: Berglund J,Kullberg J

    更新日期:2012-06-01 00:00:00

  • Fast and accurate calculation of myocardial T1 and T2 values using deep learning Bloch equation simulations (DeepBLESS).

    abstract:PURPOSE:To propose and evaluate a deep learning model for rapid and accurate calculation of myocardial T1 /T2 values based on a previously proposed Bloch equation simulation with slice profile correction (BLESSPC) method. METHODS:Deep learning Bloch equation simulations (DeepBLESS) models are proposed for rapid and ac...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28321

    authors: Shao J,Ghodrati V,Nguyen KL,Hu P

    更新日期:2020-11-01 00:00:00

  • Electrocardiogram acquisition during MR examinations for patient monitoring and sequence triggering.

    abstract::We have developed a method for measuring the electrocardiogram (ECG) continuously during MR examinations. In contrast to ECG acquisition by wires, our new method is to amplify and convert the ECG into an optical signal directly above the patient's heart. The optical signal is transmitted out of the magnet bore by opti...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910320416

    authors: Felblinger J,Lehmann C,Boesch C

    更新日期:1994-10-01 00:00:00

  • Uncertainties of calculated Cramér-Rao lower bounds: implications for quantitative MRS.

    abstract:PURPOSE:To investigate the uncertainties on relative Cramér-Rao lower bound (rCRB) estimates and demonstrate their biasing effects in MRS quantification. THEORY AND METHODS:Simulations were performed to calculate the distribution of the computed rCRB (noted rCRB*) for several rCRB levels. One hundred thousand simulati...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27415

    authors: Bonny JM,Pagès G

    更新日期:2019-02-01 00:00:00

  • Susceptibility mapping in the human brain using threshold-based k-space division.

    abstract::A method for calculating quantitative three-dimensional susceptibility maps from field measurements acquired using gradient echo imaging at high field is presented. This method is based on division of the three-dimensional Fourier transforms of high-pass-filtered field maps by a simple function that is the Fourier tra...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22334

    authors: Wharton S,Schäfer A,Bowtell R

    更新日期:2010-05-01 00:00:00

  • Strain-dependent T1 relaxation profiles in articular cartilage by MRI at microscopic resolutions.

    abstract::To investigate the dependency of T(1) relaxation on mechanical strain in articular cartilage, quantitative magnetic resonance T(1) imaging experiments were carried out on cartilage before/after the tissue was immersed in gadolinium contrast agent and when the tissue was being compressed (up to ∼ 48% strains). The spat...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22933

    authors: Xia Y,Wang N,Lee J,Badar F

    更新日期:2011-06-01 00:00:00

  • Constrained length minimum inductance gradient coil design.

    abstract::A gradient coil design algorithm capable of controlling the position of the homogeneous region of interest (ROI) with respect to the current-carrying wires is required for many advanced imaging and spectroscopy applications. A modified minimum inductance target field method that allows the placement of a set of constr...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910390214

    authors: Chronik BA,Rutt BK

    更新日期:1998-02-01 00:00:00

  • Solvate structures in water-methanol solutions of MRI contrast agents: electron spin echo envelope modulation in gadolinium chelates.

    abstract::Electron Spin Echo Envelope Modulation (ESEEM) data are reported for three gadolinium (III) chelates, Gd-EDTA, Gd-DTPA, and Gd-TTHA, in frozen D2O/CH3OD glasses. This series includes Gd-DTPA, an MRI contrast agent that is in clinical use. Three-pulse electron spin echo modulation patterns can be modeled to yield geome...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910290414

    authors: Clarkson RB,Hwang JH,Belford RL

    更新日期:1993-04-01 00:00:00

  • Out-and-in spiral spectroscopic imaging in rat brain at 7 T.

    abstract::With standard spectroscopic imaging, high spatial resolution is achieved at the price of a large number of phase-encoding steps, leading to long acquisition times. Fast spatial encoding methods reduce the minimum total acquisition time. In this article, a k-space scanning scheme using a continuous series of growing an...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10622

    authors: Hiba B,Faure B,Lamalle L,Décorps M,Ziegler A

    更新日期:2003-12-01 00:00:00

  • Brain water diffusion in normal and creatine-supplemented rats during transient global ischemia.

    abstract::Brain water diffusion in response to transient global ischemia (12 min), reperfusion (60 min), and cardiac arrest was monitored by localized proton magnetic resonance spectroscopy. The trace of the apparent diffusion coefficient tensor (ADC(Av)) was determined at high temporal resolution (10 sec) to assess the putativ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199910)42:4<798::aid-mrm23

    authors: Wick M,Fujimori H,Michaelis T,Frahm J

    更新日期:1999-10-01 00:00:00

  • Statistical artifacts in diffusion tensor MRI (DT-MRI) caused by background noise.

    abstract::This work helps elucidate how background noise introduces statistical artifacts in the distribution of the sorted eigenvalues and eigenvectors in diffusion tensor MRI (DT-MRI) data. Although it was known that sorting eigenvalues (principal diffusivities) by magnitude introduces a bias in their sample mean within a hom...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/1522-2594(200007)44:1<41::aid-mrm8>3.0.co;

    authors: Basser PJ,Pajevic S

    更新日期:2000-07-01 00:00:00

  • Effect of feature extraction for brain tumor classification based on short echo time 1H MR spectra.

    abstract::This study examines the effect of feature extraction methods prior to automated pattern recognition based on magnetic resonance spectroscopy (MRS) for brain tumor diagnosis. Since individual inspection of spectra is time-consuming and requires specific spectroscopic expertise, the introduction of clinical decision sup...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21626

    authors: Luts J,Poullet JB,Garcia-Gomez JM,Heerschap A,Robles M,Suykens JA,Van Huffel S

    更新日期:2008-08-01 00:00:00

  • x-f Choice: reconstruction of undersampled dynamic MRI by data-driven alias rejection applied to contrast-enhanced angiography.

    abstract::A technique for reconstructing dynamic undersampled MRI data, termed "x-f choice," was developed and applied to dynamic contrast-enhanced MR angiography (DCE-MRA). Regular undersampling in k-t space (a hybrid of k-space and time) creates aliasing in the conjugate x-f space that must be resolved. When regions in the ob...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21008

    authors: Malik SJ,Schmitz S,O'Regan D,Larkman DJ,Hajnal JV

    更新日期:2006-10-01 00:00:00

  • Complete elimination of the extracellular 23Na NMR signal in triple quantum filtered spectra of rat hearts in the presence of shift reagents.

    abstract::A method is suggested whereby the shifted extracellular triple quantum filtered 23Na signal of an isolated organ is completely eliminated. The method is based on the long relaxation time of the triple quantum coherence and on its fast evolution rate. When the carrier frequency is set on top of the intracellular sodium...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910300415

    authors: Navon G

    更新日期:1993-10-01 00:00:00

  • A continuum of T 2 * components: Flexible fast fraction mapping in sodium MRI.

    abstract:PURPOSE:Parameter mapping in sodium MRI data is challenging due to inherently low SNR and spatial resolution, prompting the need to employ robust models and estimation techniques. This work aims to develop a continuum model of sodium T 2 ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27659

    authors: Syeda W,Blunck Y,Kolbe S,Cleary JO,Johnston LA

    更新日期:2019-06-01 00:00:00