Polymetallic macromolecules are potential contrast agents of improved efficiency.

Abstract:

:The commercial synthetic homopolypeptide polyaspartate (average MW = 30,000, approximately 220 monomers) in solution quantitatively binds up to 40 mol Gd3+ ions per mole of polyaspartate. The water proton relaxivity of the solutions is far higher than that of clinically used or commonly investigated gadolinium(III) complexes. It is shown that polymetallic macromolecular complexes combine the high relaxing efficiency of monometallic macromolecular complexes with the favorable metal/ligand mass ratio of small monometallic complexes.

journal_name

Magn Reson Med

authors

Cavagna F,Luchinat C,Scozzafava A,Xia Z

doi

10.1002/mrm.1910310109

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

58-60

issue

1

eissn

0740-3194

issn

1522-2594

journal_volume

31

pub_type

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