Effect of lanthanide ions on dynamic nuclear polarization enhancement and liquid-state T1 relaxation.

Abstract:

:In the dynamic nuclear polarization process, microwave irradiation facilitates exchange of polarization from a radical's unpaired electron to nuclear spins at cryogenic temperatures, increasing polarization by >10,000. Doping samples with Gd(3+) ions further increases the achievable solid-state polarization. However, on dissolution, paramagnetic lanthanide metals can be potent relaxation agents, decreasing liquid-state polarization. Here, the effects of lanthanide metals on the solid and liquid-state magnetic properties of [1-(13)C]pyruvate are studied. The results show that in addition to gadolinium, holmium increases not only the achievable polarization but also the rate of polarization. Liquid-state relaxation studies found that unlike gadolinium, holmium minimally affects T(1). Additionally, results reveal that linear contrast agents dissociate in pyruvic acid, greatly reducing liquid-state T(1). Although macrocyclic agents do not readily dissociate, they yield lower solid-state polarization. Results indicate that polarization with free lanthanides and subsequent chelation during dissolution produces the highest polarization enhancement while minimizing liquid-state relaxation.

journal_name

Magn Reson Med

authors

Gordon JW,Fain SB,Rowland IJ

doi

10.1002/mrm.24207

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

1949-54

issue

6

eissn

0740-3194

issn

1522-2594

journal_volume

68

pub_type

杂志文章
  • Strategy for the spectral filtering of myo-inositol and other strongly coupled spins.

    abstract::A multiple quantum filter strategy is presented for spectrally discriminating metabolites with strongly coupled spins from those whose spins are either uncoupled or weakly coupled. The strategy also includes a means for selectively suppressing the background multiplets of metabolites that also have strongly coupled sp...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10697

    authors: Kim H,Wild JM,Allen PS

    更新日期:2004-02-01 00:00:00

  • Gadodiamide T1 relaxivity in brain tissue in vivo is lower than in saline.

    abstract::In vivo measurements of gadodiamide (Gd-DTPA-BMA) T(1) relaxivity were performed at 4.7 T in injured and normal rat brains. Cerebral lesions were induced in nine rats by a localized freezing method. T(1) maps of the lesions were generated before and after injection of Gd-DTPA-BMA (0.1-0.6 mmol/kg). Samples of normal a...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20336

    authors: Pickup S,Wood AK,Kundel HL

    更新日期:2005-01-01 00:00:00

  • Diffusion sensitivity of 3D-GRASE in arterial spin labeling perfusion.

    abstract:PURPOSE:To evaluate the role of true diffusion and flow-related pseudodiffusion in cerebral blood flow (CBF) quantification using arterial spin labeling (ASL) with single-shot or segmented 3D gradient and spin echo (GRASE) readouts. THEORY:The extended phase graph (EPG) algorithm, originally designed to model the effe...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27058

    authors: He X,Wengler K,Schweitzer ME

    更新日期:2018-08-01 00:00:00

  • NOE enhancements and T1 relaxation times of phosphorylated metabolites in human calf muscle at 1.5 Tesla.

    abstract::Nuclear Overhauser effect (NOE) enhancements and relaxation times of 31P metabolites in human calf were measured in 12 volunteers (4 men and 8 women) at 1.5 T using a dual tuned four-ring birdcage. The NOE enhancements of inorganic phosphate (Pi), phosphocreatine (PCr), gamma-, alpha-, and beta-nucleoside triphosphate...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910330316

    authors: Brown TR,Stoyanova R,Greenberg T,Srinivasan R,Murphy-Boesch J

    更新日期:1995-03-01 00:00:00

  • Single-shot two-echo technique for simultaneous measurement of GABA and creatine in the human brain in vivo.

    abstract::A single-shot, two-echo method for the simultaneous detection of multiple-quantum (MQ)-filtered gamma-aminobutyric acid (GABA) and creatine (Cr) was developed and demonstrated in the human brain in vivo at 3 Tesla. The simultaneously measured Cr singlet served as a navigator for the spectral phase of GABA and any freq...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20082

    authors: Choi IY,Lee SP,Merkle H,Shen J

    更新日期:2004-06-01 00:00:00

  • Stability constants and 1H relaxation effects of ternary complexes formed between Gd-DTPA, Gd-DTPA-BMA, Gd-DOTA, and Gd-EDTA and citrate, phosphate, and carbonate ions.

    abstract::Formation of ternary complexes between Gd-DTPA, Gd-DTPA-BMA, and Gd-DOTA, used as contrast enhancement agents in MRI and the endogenously available carbonate and phosphate ions, has been demonstrated. The extent of ternary complex formation and its effect on the proton relaxation, measured at 9 MHz, rates is negligibl...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910380120

    authors: Burai L,Hietapelto V,Király R,Tóth E,Brücher E

    更新日期:1997-07-01 00:00:00

  • Systematic analysis of the intravoxel incoherent motion threshold separating perfusion and diffusion effects: Proposal of a standardized algorithm.

    abstract:PURPOSE:To systematically evaluate the dependence of intravoxel-incoherent-motion (IVIM) parameters on the b-value threshold separating the perfusion and diffusion compartment, and to implement and test an algorithm for the standardized computation of this threshold. METHODS:Diffusion weighted images of the upper abdo...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25506

    authors: Wurnig MC,Donati OF,Ulbrich E,Filli L,Kenkel D,Thoeny HC,Boss A

    更新日期:2015-11-01 00:00:00

  • Out-and-in spiral spectroscopic imaging in rat brain at 7 T.

    abstract::With standard spectroscopic imaging, high spatial resolution is achieved at the price of a large number of phase-encoding steps, leading to long acquisition times. Fast spatial encoding methods reduce the minimum total acquisition time. In this article, a k-space scanning scheme using a continuous series of growing an...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10622

    authors: Hiba B,Faure B,Lamalle L,Décorps M,Ziegler A

    更新日期:2003-12-01 00:00:00

  • PRESTO-SENSE: an ultrafast whole-brain fMRI technique.

    abstract::A new ultrafast MR imaging method is proposed and tested, which enables whole-brain fMRI with a true temporal resolution of 1 sec. The method combines a 3D PRESTO pulse sequence with the concept of sensitivity-encoding with multiple receiver coils (SENSE). The so-called PRESTO-SENSE technique is demonstrated on a set ...

    journal_title:Magnetic resonance in medicine

    pub_type: 临床试验,杂志文章

    doi:10.1002/1522-2594(200006)43:6<779::aid-mrm1>3.0.co

    authors: Golay X,Pruessmann KP,Weiger M,Crelier GR,Folkers PJ,Kollias SS,Boesiger P

    更新日期:2000-06-01 00:00:00

  • Real-time interactive MRI-guided cardiac surgery: aortic valve replacement using a direct apical approach.

    abstract::Minimally invasive cardiac surgery requires arresting and emptying of the heart, which compromises visualization of the surgical field. In this feasibility study a novel surgical procedure is demonstrated in which real-time MRI is used to guide the placement of a prosthetic aortic valve in the beating heart via direct...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21044

    authors: McVeigh ER,Guttman MA,Lederman RJ,Li M,Kocaturk O,Hunt T,Kozlov S,Horvath KA

    更新日期:2006-11-01 00:00:00

  • Prospective GIRF-based RF phase cycling to reduce eddy current-induced steady-state disruption in bSSFP imaging.

    abstract:PURPOSE:To propose an explicit Balanced steady-state free precession (bSSFP) signal model that predicts eddy current-induced steady-state disruptions and to provide a prospective, practical, and general eddy current compensation method. THEORY AND METHODS:Gradient impulse response functions (GIRF) were used to simulat...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28097

    authors: Bruijnen T,Stemkens B,van den Berg CAT,Tijssen RHN

    更新日期:2020-07-01 00:00:00

  • Commutator filter: a novel technique for the identification of structures producing significant susceptibility inhomogeneities and its application to functional MRI.

    abstract::A robust postprocessing method to detect regions of magnetic field change is presented. High resolution gradient echo data is acquired to create a complex baseline image. From this image, two low resolution images are obtained by applying a low pass filter on the magnitude image and the complex image, respectively. Su...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910360518

    authors: Lai S,Reichenbach JR,Haacke EM

    更新日期:1996-11-01 00:00:00

  • Effects of acute normovolemic hemodilution on T2*-weighted images of rat brain.

    abstract::Acute normovolemic hemodilution (HD) was induced in anesthetized rats to assess the effect of changes in hematocrit (Hct) on signal intensity in T2*-weighted magnetic resonance (MR) images. Other relevant physiological parameters were maintained invariant. Two degrees of HD were induced: mild (Hct reduced from 42.6+/-...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910400611

    authors: Lin W,Paczynski RP,Celik A,Hsu CY,Powers WJ

    更新日期:1998-12-01 00:00:00

  • Apparent diffusion of water, ions, and small molecules in the Xenopus oocyte is consistent with Brownian displacement.

    abstract::The incoherent displacement of water in living tissues is of considerable interest because of the widespread use of diffusion-weighted MRI, for which image contrast is based on the water apparent diffusion coefficient (ADC). It has been hypothesized that the decrease in water ADC associated with brain injury is primar...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10181

    authors: Sehy JV,Ackerman JJ,Neil JJ

    更新日期:2002-07-01 00:00:00

  • Cardiac transfer function relating energy metabolism to workload in different species as studied with 31P NMR.

    abstract::Cardiac metabolism was studied with 31P NMR in 7 dogs and 4 cats to determine whether animals adapted for different life-styles (stalk and sprint vs endurance running) respond to increased work loads (heart rate X blood pressure product) with different high-energy phosphate kinetics. Hearts were exposed via a left lat...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910040203

    authors: Ligeti L,Osbakken MD,Clark BJ,Schnall M,Bolinger L,Subramanian H,Leigh JS,Chance B

    更新日期:1987-02-01 00:00:00

  • Fat-suppressed alternating-SSFP for whole-brain fMRI using breath-hold and visual stimulus paradigms.

    abstract:PURPOSE:To achieve artifact-suppressed whole-brain pass-band-balanced steady-state free precession functional MRI from a single functional magnetic resonance imaging (fMRI) scan. METHODS:A complete and practical data acquisition sequence for alt-SSFP fMRI was developed. First, multishot flyback-echo-planar imaging (EP...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25797

    authors: Jou T,Patterson S,Pauly JM,Bowen CV

    更新日期:2016-05-01 00:00:00

  • Characterization and correction of center-frequency effects in X-nuclear eddy current compensations on a clinical MR system.

    abstract:PURPOSE:The aim of the study was to investigate whether incorrectly compensated eddy currents are the source of persistent X-nuclear spectroscopy and imaging artifacts, as well as methods to correct this. METHODS:Pulse-acquire spectra were collected for 1 H and X-nuclei (23 Na or 31 P) using the minimum TR permitted o...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28607

    authors: McLean MA,Hinks RS,Kaggie JD,Woitek R,Riemer F,Graves MJ,McIntyre DJO,Gallagher FA,Schulte RF

    更新日期:2020-12-04 00:00:00

  • Assessing linear time-invariance in human primary somatosensory cortex with BOLD fMRI using vibrotactile stimuli.

    abstract::The assumption of linear time-invariance (LTI) in the human primary somatosensory cortex (SI) is assessed for fMRI signals generated by variable-duration vibrotactile stimuli. Predictions based on time-shifted summation (TSS) of responses to 2 s stimuli overestimate observed BOLD signal amplitudes in response to longe...

    journal_title:Magnetic resonance in medicine

    pub_type: 临床试验,杂志文章

    doi:10.1002/mrm.20363

    authors: Nangini C,Macintosh BJ,Tam F,Staines WR,Graham SJ

    更新日期:2005-02-01 00:00:00

  • A hybrid method for more efficient channel-by-channel reconstruction with many channels.

    abstract::In MRI, imaging using receiving coil arrays with a large number of elements is an area of growing interest. With increasing channel numbers for parallel acquisition, longer reconstruction times have become a significant concern. Channel reduction techniques have been proposed to reduce the processing time of channel-b...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23048

    authors: Huang F,Lin W,Duensing GR,Reykowski A

    更新日期:2012-03-01 00:00:00

  • Electromagnetic fields of surface coil in vivo NMR at high frequencies.

    abstract::A high frequency solution of the electromagnetic field produced by a circular surface coil adjacent to a homogeneous conducting, dielectric sphere is used to predict the attainable signal to noise ratio (S/N) and specific absorption rate (SAR) for in vivo 1H NMR spectroscopy experiments from 200 to 430 MHz (4.7-10 T)....

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910220254

    authors: Keltner JR,Carlson JW,Roos MS,Wong ST,Wong TL,Budinger TF

    更新日期:1991-12-01 00:00:00

  • Detection of liver fibrosis with magnetic cross-relaxation.

    abstract::The utility of MRI using magnetization transfer (MT) enhanced pulse sequences to diagnose hepatic cirrhosis in a rat model was investigated. Hepatic T1 was measured with and without MT off-resonance RF pulses in 17 treated and six control rats. The livers were evaluated histologically, and the hydroxyproline content q...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910310513

    authors: Aisen AM,Doi K,Swanson SD

    更新日期:1994-05-01 00:00:00

  • Sliding time of flight: sliding time of flight MR angiography using a dynamic image reconstruction method.

    abstract:PURPOSE:To obtain three-dimensional (3D) MR angiography having high contrast between vessel and stationary background tissue, a novel technique called sliding time of flight (TOF) is proposed. METHODS:The proposed method relies on the property that flow-related enhancement (FRE) is maximized at the blood-entering slic...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25215

    authors: Choi J,Seo H,Lim Y,Han Y,Park H

    更新日期:2015-03-01 00:00:00

  • Magnetization transfer contrast-suppressed imaging of amide proton transfer and relayed nuclear overhauser enhancement chemical exchange saturation transfer effects in the human brain at 7T.

    abstract:PURPOSE:To use the variable delay multipulse (VDMP) chemical exchange saturation transfer (CEST) approach to obtain clean amide proton transfer (APT) and relayed Nuclear Overhauser enhancement (rNOE) CEST images in the human brain by suppressing the conventional magnetization transfer contrast (MTC) and reducing the di...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25990

    authors: Xu X,Yadav NN,Zeng H,Jones CK,Zhou J,van Zijl PC,Xu J

    更新日期:2016-01-01 00:00:00

  • Stability assessment of gadolinium complexes by P-31 and H-1 relaxometry.

    abstract::Longitudinal P-31 relaxation rate enhancements of phosphate groups have been measured at pH 7-7.2 and 310 degrees K on aqueous solutions containing adenosine triphosphate (ATP), phosphocreatine (PCr), inorganic phosphate (Pi) and some lanthanide complexes (Gd-DOTA, Gd-HPDO3A, Gd-DO3A, Gd-DTPA, Gd-DTPA-BMA). The macroc...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910310413

    authors: Vander Elst L,Van Haverbeke Y,Goudemant JF,Muller RN

    更新日期:1994-04-01 00:00:00

  • A single acquisition localization technique.

    abstract::A method is demonstrated for detection of magnetization from a selected region within the sensitive volume of a surface coil in a single acquisition. Composite pulses are described which eliminate signals from regions where magnetization is rotated 270 and 450 degrees. There is a loss of 1.3% or less of signal from re...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910030221

    authors: Karczmar GS,Matson GB,Weiner MW

    更新日期:1986-04-01 00:00:00

  • Water and fat MR imaging with chemical shift selective 3D steady state methods.

    abstract::A new 3D acquisition regimen that enables the collection of conventional, water-suppressed, and fat-suppressed images with no increase in scan times compared with currently implemented 3D sequences is presented. The method is based on conventional 3D steady state with interleaved selective excitation of the fat resona...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910310403

    authors: Sun L,Aletras AH,Schmalbrock P,Skinner TE,Chakeres D,Irsik R,Robitaille PM

    更新日期:1994-04-01 00:00:00

  • Assessment of myocardial viability in rats: Evaluation of a new method using superparamagnetic iron oxide nanoparticles and Gd-DOTA at high magnetic field.

    abstract::The aim of this study was to detect salvageable peri-infarction myocardium by MRI in rats after infarction, using with a double contrast agent (CA) protocol at 7 Tesla. Intravascular superparamagnetic iron oxide (SPIO) nanoparticles and an extracellular paramagnetic CA (Gd-DOTA) were used to characterize the peri-infa...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20210

    authors: Chapon C,Lemaire L,Franconi F,Marescaux L,Legras P,Denizot B,Le Jeune JJ

    更新日期:2004-10-01 00:00:00

  • Variable flip angle 3D-GRASE for high resolution fMRI at 7 tesla.

    abstract:PURPOSE:To evaluate the use of variable flip angle refocusing pulse trains in single-shot three-dimensional gradient and spin-echo (3D-GRASE) to reduce blurring and increase the spatial coverage for high spatial resolution T2 -weighted functional MRI at 7 Tesla. METHODS:Variable flip angle refocusing schemes in 3D-GRA...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25979

    authors: Kemper VG,De Martino F,Yacoub E,Goebel R

    更新日期:2016-09-01 00:00:00

  • NMR changes in experimental allergic encephalomyelitis: NMR changes precede clinical and pathological events.

    abstract::In guinea pigs immunized with myelin basic protein (MBP) in complete Freund's adjuvant, experimental allergic encephalomyelitis (EAE) shows a characteristic clinical and pathological course. This study characterized the proton nuclear magnetic resonance (NMR) properties of the central nervous system prior to the onset...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910050203

    authors: O'Brien JT,Noseworthy JH,Gilbert JJ,Karlik SJ

    更新日期:1987-08-01 00:00:00

  • Magnetic susceptibility as a B0 field strength independent MRI biomarker of liver iron overload.

    abstract:PURPOSE:MR-based quantification of liver magnetic susceptibility may enable field strength-independent measurement of liver iron concentration (LIC). However, susceptibility quantification is challenging, due to nonlocal effects of susceptibility on the B0 field. The purpose of this work is to demonstrate feasibility o...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24848

    authors: Hernando D,Cook RJ,Diamond C,Reeder SB

    更新日期:2013-09-01 00:00:00