Stability constants and 1H relaxation effects of ternary complexes formed between Gd-DTPA, Gd-DTPA-BMA, Gd-DOTA, and Gd-EDTA and citrate, phosphate, and carbonate ions.

Abstract:

:Formation of ternary complexes between Gd-DTPA, Gd-DTPA-BMA, and Gd-DOTA, used as contrast enhancement agents in MRI and the endogenously available carbonate and phosphate ions, has been demonstrated. The extent of ternary complex formation and its effect on the proton relaxation, measured at 9 MHz, rates is negligible at around pH < 8. The complex Gd-EDTA forms more stable ternary complexes with carbonate and phosphate and it also strongly coordinates the terdentate citrate ligand. The formation of ternary complexes Gd-EDTA(X) (X = CO3(2-), Cit3-) results in a significant decrease in the proton relaxation rates under physiological conditions.

journal_name

Magn Reson Med

authors

Burai L,Hietapelto V,Király R,Tóth E,Brücher E

doi

10.1002/mrm.1910380120

subject

Has Abstract

pub_date

1997-07-01 00:00:00

pages

146-50

issue

1

eissn

0740-3194

issn

1522-2594

journal_volume

38

pub_type

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