Abstract:
:The utility of MRI using magnetization transfer (MT) enhanced pulse sequences to diagnose hepatic cirrhosis in a rat model was investigated. Hepatic T1 was measured with and without MT off-resonance RF pulses in 17 treated and six control rats. The livers were evaluated histologically, and the hydroxyproline content quantitatively measured. We did not find a statistically significant linear correlation between the MR relaxation times and the degree of tissue injury. However, the MR measurements performed with MT were superior to those without differentiating the treated and control groups. Specifically, the T1 times were 695 +/- 76 ms for the treated group, versus 748 +/- 61 ms in the controls; P = 0.095. The T1sat times were also lower in the treated group, with statistical significance: 367 +/- 51 ms versus 421 +/- 38 ms, P = 0.016. Finally, the change in the relaxation rates (the inverse of the relaxation times) with and without saturation were 1.31 +/- 0.22 s-1 (treated group) versus 1.05 +/- 0.12 s-1 (controls), which differed significantly, P = 0.001.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Aisen AM,Doi K,Swanson SDdoi
10.1002/mrm.1910310513subject
Has Abstractpub_date
1994-05-01 00:00:00pages
551-6issue
5eissn
0740-3194issn
1522-2594journal_volume
31pub_type
杂志文章abstract::The accurate assessment of pulmonary perfusion is especially important in the evaluation of patients with suspected pulmonary embolism, a common and potentially lethal disorder that can be treated by aggressive anticoagulation. In this study, we demonstrate for the first time the use of MR to image pulmonary perfusion...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910360402
更新日期:1996-10-01 00:00:00
abstract::A novel linear parameterization for the variable flip angle method for longitudinal relaxation time T(1) quantification from spoiled steady state MRI is derived from the half angle tangent transform, τ, of the flip angle. Plotting the signal S at coordinates x=Sτ and y=S/τ, respectively, establishes a line that render...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22849
更新日期:2011-09-01 00:00:00
abstract:PURPOSE:To explore the effects of high permittivity dielectric pads on the transmit and receive characteristics of a 3 Tesla body coil centered at the thighs, and their implications on image uniformity in receive array applications. THEORY AND METHODS:Transmit and receive profiles of the body coil with and without die...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26070
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:Respiratory motion makes hepatic ablation using high intensity focused ultrasound (HIFO) challenging. Previous HIFU liver treatment had required apnea induced during general anesthesia. We describe and test a system that allows treatment of the liver in the presence of breathing motion. METHODS:Mapping a signa...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24695
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:To systematically evaluate the dependence of intravoxel-incoherent-motion (IVIM) parameters on the b-value threshold separating the perfusion and diffusion compartment, and to implement and test an algorithm for the standardized computation of this threshold. METHODS:Diffusion weighted images of the upper abdo...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25506
更新日期:2015-11-01 00:00:00
abstract::We improved the three-point phase-contrast method by regularization of MR velocity data after acquisition of a low velocity-to-noise ratio (VNR) velocity image and a high VNR aliased velocity image. The phase unwrapping algorithm is based on the assumed correlation of the velocity of adjacent flow voxels on the low VN...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/1522-2594(200007)44:1<122::aid-mrm18>3.0.c
更新日期:2000-07-01 00:00:00
abstract::A method for volume selective proton spectroscopy is presented based on a multiecho sequence with short refocusing interval tcp. It is demonstrated, that by appropriate choice of tcp on the order of 4-6 ms, signals from overlapping multiplets like the glutamine and glutamate (Glu/Gln) resonances in spectra of the huma...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910370603
更新日期:1997-06-01 00:00:00
abstract::A new k-space direct matrix inversion (DMI) method is proposed here to accelerate non-Cartesian SENSE reconstructions. In this method a global k-space matrix equation is established on basic MRI principles, and the inverse of the global encoding matrix is found from a set of local matrix equations by taking advantage ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20974
更新日期:2006-08-01 00:00:00
abstract::An in vitro study was performed to investigate the effects of B(o) inhomogeneity on magnetic resonance images of flow. Controlled inhomogeneity gradients (Gi) were applied and the magnitude of the artifacts produced was quantified for different echo delay times (TE). Both steady and pulsatile flows were examined. In t...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910350116
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:To significantly reduce the background phase effects, especially at the air-tissue interface, and to enhance the desirable local structures of veins in susceptibility-weighted imaging. METHODS:In the proposed reconstruction method called Magnitude of Complex Filtering, a complex-valued magnetic resonance image...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24776
更新日期:2014-03-01 00:00:00
abstract::Two different types of (co-registered) images of the same slice of tissue will generally have different spatial resolutions. The judicious pixel-by-pixel combination of their data can be accomplished to yield a single image exhibiting properties of both. Here, axial (18)FDG PET and (1)H(2)O MR images of the human brai...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199908)42:2<345::aid-mrm17
更新日期:1999-08-01 00:00:00
abstract::A method for calculating quantitative three-dimensional susceptibility maps from field measurements acquired using gradient echo imaging at high field is presented. This method is based on division of the three-dimensional Fourier transforms of high-pass-filtered field maps by a simple function that is the Fourier tra...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22334
更新日期:2010-05-01 00:00:00
abstract::The ultra-fast application of the RARE experiment is described in detail, with special emphasis on its multifarious applications with preparation experiments that produce transverse magnetization. The factors affecting the temporal evolution of the magnetization during the experiment are described, and the implication...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910270114
更新日期:1992-09-01 00:00:00
abstract::Spiral k-space magnetic resonance spectroscopic imaging (MRSI) requires high performance from gradient hardware systems. During the readout phase, oscillating gradients are continuously played out, which can cause undesired effects. These effects on the quality of SI data are non-intuitive because of their time-varyin...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20928
更新日期:2006-07-01 00:00:00
abstract::We developed a quantitative magnetic resonance imaging method to permit a rapid assessment of brain water content during osmotic brain edema produced by intraperitoneal (ip) injection of distilled water. Fifteen minutes after water injection, the normalized mean image intensity (MIn) from a spin-echo pulse sequence (T...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910240107
更新日期:1992-03-01 00:00:00
abstract::The theoretical description of steady state free precession (SSFP) sequences is generally well accepted and unquestioned, although it is based on instantaneously acting radiofrequency (RF) pulses. In practice, however, all excitation processes are finite, thereby questioning the overall validity of the common SSFP sig...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22116
更新日期:2009-11-01 00:00:00
abstract::Activity-induced manganese-dependent contrast (AIM) MRI is a hemodynamic-independent functional MRI method that used manganese ion as an MR-detectable contrast agent. In AIM, MnCl(2) is infused intra-arterially after the blood-brain barrier (BBB) is opened with a hyperosmolar agent. Upon functional stimulation of the ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10320
更新日期:2002-12-01 00:00:00
abstract::This study investigated the use of peritoneal dialysis fluid (dialyzate) as a MR contrast agent to visualize the liver structure and peritoneal adhesion in rats at 7 T. Intraperitoneal injection of dialyzate (approximately 0.1 ml/g) yielded excellent and consistent intraperitoneal enhancement that delineated the liver...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21506
更新日期:2008-05-01 00:00:00
abstract::The use of paramagnetic pH-sensitive liposomes was recently suggested as a new approach for monitoring pathologic changes in pH by MRI. Such liposomes must be stable in blood and selectively release the encapsulated paramagnetic agent when exposed to lower pH in the target tissue. In the present study, different lipos...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20009
更新日期:2004-04-01 00:00:00
abstract::Fe(III)meso-tetra(4-sulfonatophenyl)porphine (Fe-TPPS4) has been investigated as a potential pH-sensitive nuclear magnetic resonance (NMR) proton image contrast agent. Relaxation rates (1/T1 and 1/T2) of water protons were measured as a function of pH and concentration of Fe-TPPS4 in phosphate-buffered isotonic saline...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910050313
更新日期:1987-09-01 00:00:00
abstract::Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl to the exposed rat cortex. MEMRI signal increase in the ipsilateral cortex relative to the contralateral control region was 60 +/- 30% following two KCl applications. MEMRI signal increase for a...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20438
更新日期:2005-04-01 00:00:00
abstract::The resolution and homogeneity limitations of echo-planar imaging (EPI) are overcome by zoom imaging of an easily shimmed localized volume. Use of the stimulated echo enables single-shot localization. In vivo 0.5-mm resolution EPI images of selected regions of a cat brain at 4.7 T are presented. ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910140225
更新日期:1990-05-01 00:00:00
abstract::A single breath-hold 3D cardiac phase resolved steady-state free precession (SSFP) sequence was developed, allowing 3D visualization of the moving coronary arteries. A 3D stack of spirals was acquired continuously throughout the cardiac cycle, and a sliding window reconstruction was used to achieve high temporal resol...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21365
更新日期:2007-09-01 00:00:00
abstract::In spin echo imaging, magnetization is assigned to a location defined by its frequency of rotation. In the presence of a static magnetic field inhomogeneity, however, this location does not correspond to the true location of the magnetization. This paper describes a magnetic resonance imaging technique called phase co...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910330407
更新日期:1995-04-01 00:00:00
abstract:PURPOSE:Sensitivity encoding (SENSE) reconstruction of multiband echo planar imaging (EPI) may cause artifacts when simultaneously excited slices require different phase correction to remove the EPI-specific ghost shifted by half of the matrix size (N). We propose a simplified solution of this problem that combines SEN...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25915
更新日期:2016-09-01 00:00:00
abstract::We report the synthesis and characterization of polyvinyl alcohol (PVA) embolic particles modified with a clinically approved magnetic resonance (MR) contrast agent. PVA particles are used during transcatheter arterial embolization (TAE) procedures and this minimally invasive technique is a widely employed treatment f...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21518
更新日期:2008-04-01 00:00:00
abstract::The time evolution of water diffusion, perfusion, T1, and T2 is investigated at high magnetic field (8.5 T) following permanent middle cerebral artery occlusion in the rat. Cerebral blood flow maps were obtained using arterial spin tagging. Although the quantitative perfusion measurements in ischemic tissue still pose...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199903)41:3<479::aid-mrm9>
更新日期:1999-03-01 00:00:00
abstract::Parallel transmission has emerged as an efficient means for implementing multidimensional spatially selective radiofrequency excitation pulses. To date, most theoretical and experimental work on parallel transmission radiofrequency (RF) pulse design is based on the small-tip-angle approximation to the Bloch equation. ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22827
更新日期:2011-09-01 00:00:00
abstract::This study demonstrates the in vitro displacement and strain of articular cartilage in a cyclically-compressed and intact joint using displacement-encoded imaging with stimulated echoes (DENSE) and fast spin echo (FSE). Deformation and strain fields exhibited complex and heterogeneous patterns. The displacements in th...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21927
更新日期:2009-04-01 00:00:00
abstract::Balanced steady-state free precession (SSFP) imaging is sensitive to off-resonance effects, which can lead to considerable artifacts during a transient phase following magnetization preparation or steady-state interruption. In addition, nonlinear k-space encoding is required if contrast-relevant k-space regions need t...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20615
更新日期:2005-10-01 00:00:00