Localized detection of glioma glycolysis using edited 1H MRS.

Abstract:

:In vivo 1H MRS can be used to detect and quantify the lactate resonance at 1.3 ppm provided that overlapping lipid resonances are eliminated. A homonuclear spectral editing method was developed to acquire uncontaminated 1H spectra of lactate with adiabatic pulses. An advantage of the adiabatic pulse sequence is the ability to induce uniform flip angles and to maximize sensitivity in applications employing surface coil transmitters which produce highly inhomogeneous B1. Glycolytic activity in an intracerebral C6 glioma in rats was monitored by using adiabatic editing sequences to observe [3-13C]lactate produced from infused [1-13C]glucose. Acute hyperglycemia (serum glucose > 22 mM, n = 10) had no significant effect (P = 0.08) on the total ([12C] + [13C]) tumor lactate signal intensity.

journal_name

Magn Reson Med

authors

Schupp DG,Merkle H,Ellermann JM,Ke Y,Garwood M

doi

10.1002/mrm.1910300105

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

18-27

issue

1

eissn

0740-3194

issn

1522-2594

journal_volume

30

pub_type

杂志文章
  • 2D multislice and 3D MRI sequences are often equally sensitive.

    abstract::A simple theoretical model was developed to compare the sensitivities (i.e., signal-to-noise ratios per unit imaging time) of two-dimensional (2D) multislice and 3D imaging sequences. The model shows that the sensitivities of 3D and 2D multislice MRI sequences are usually similar. Sensitivities are identical in T2-wei...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199904)41:4<824::aid-mrm23

    authors: Johnson G,Wadghiri YZ,Turnbull DH

    更新日期:1999-04-01 00:00:00

  • A torque balance measurement of anisotropy of the magnetic susceptibility in white matter.

    abstract:PURPOSE:Recent MRI studies have suggested that the magnetic susceptibility of white matter (WM) in the human brain is anisotropic, providing a new contrast mechanism for the visualization of fiber bundles and allowing the extraction of cellular compartment-specific information. This study provides an independent confir...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25524

    authors: van Gelderen P,Mandelkow H,de Zwart JA,Duyn JH

    更新日期:2015-11-01 00:00:00

  • Multiclass imbalance learning: Improving classification of pediatric brain tumors from magnetic resonance spectroscopy.

    abstract:PURPOSE:Classification of pediatric brain tumors from 1 H-magnetic resonance spectroscopy (MRS) can aid diagnosis and management of brain tumors. However, varied incidence of the different tumor types leads to imbalanced class sizes and introduces difficulties in classifying rare tumor groups. This study assessed diffe...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26318

    authors: Zarinabad N,Wilson M,Gill SK,Manias KA,Davies NP,Peet AC

    更新日期:2017-06-01 00:00:00

  • Quantifying endogenous glucose production and contributing source fluxes from a single 2H NMR spectrum.

    abstract::Endogenous glucose production (EGP), gluconeogenic and glycogenolytic fluxes by analysis of a single (2)H-NMR spectrum is demonstrated with 6-hr and 24-hr fasted rats. Animals were administered [1-(2)H, 1-(13)C]glucose, a novel tracer of glucose turnover, and (2)H(2)O. Plasma glucose enrichment from both tracers was q...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22062

    authors: Nunes PM,Jones JG

    更新日期:2009-09-01 00:00:00

  • Total liver fat quantification using three-dimensional respiratory self-navigated MRI sequence.

    abstract:PURPOSE:MRI can produce quantitative liver fat fraction (FF) maps noninvasively, which can help to improve diagnoses of fatty liver diseases. However, most sequences acquire several two-dimensional (2D) slices during one or more breath-holds, which may be difficult for patients with limited breath-holding capacity. A w...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26028

    authors: Arboleda C,Aguirre-Reyes D,García MP,Tejos C,Muñoz L,Miquel JF,Irarrazaval P,Andia ME,Uribe S

    更新日期:2016-11-01 00:00:00

  • Whole-heart steady-state free precession coronary artery magnetic resonance angiography.

    abstract::Current implementations of coronary artery magnetic resonance angiography (MRA) suffer from limited coverage of the coronary arterial system. Whole-heart coronary MRA was implemented based on a free-breathing steady-state free-precession (SSFP) technique with magnetization preparation. The technique was compared to a ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10653

    authors: Weber OM,Martin AJ,Higgins CB

    更新日期:2003-12-01 00:00:00

  • A highly sensitive lactate editing technique for surface coil spectroscopic imaging in vivo.

    abstract::A lactate editing sequence based on the use of spin-locking pulses with surface coils is described. The sequence retains more than 90% of the available lactate magnetization and suppresses at least 95% of the lipid signal in a single scan and ca. 99.5% after a simple two step cycle. The technique allows simultaneous o...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910290320

    authors: Bourgeois D,Kozlowski P

    更新日期:1993-03-01 00:00:00

  • Identification of a characteristic 31P NMR signal in acute experimental pancreatitis with the aid of 1H-31P correlated 2D measurements of intact pancreas.

    abstract::Two-dimensional 1H-31P correlation spectroscopy and relaxation time measurements of intact diseased pancreas were performed in order to identify an unknown peak appearing at -0.18 +/- 0.04 ppm in a 31P NMR spectrum of taurocholate-induced experimental acute pancreatitis in rats. The signal was identified as a solubili...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910100111

    authors: Kushnir T,Kaplan O,Askenasy N,Navon G

    更新日期:1989-04-01 00:00:00

  • Dynamic per slice shimming for simultaneous brain and spinal cord fMRI.

    abstract:PURPOSE:Simultaneous brain and spinal cord functional MRI is emerging as a new tool to study the central nervous system but is challenging. Poor B0 homogeneity and small size of the spinal cord are principal obstacles to this nascent technology. Here we extend a dynamic shimming approach, first posed by Finsterbusch, b...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27388

    authors: Islam H,Law CSW,Weber KA,Mackey SC,Glover GH

    更新日期:2019-02-01 00:00:00

  • Detection and volume determination of colonic tumors in Min mice by magnetic resonance micro-imaging.

    abstract::We applied MRI to the in vivo detection of spontaneous colorectal tumors in a unique mouse model, the Fox Chase Cancer Center (FCCC) ApcMIN mouse. Unlike other Min (multiple intestinal neoplasia) strains, FCCC ApcMIN animals develop an appreciable number of tumors in the large intestine, which makes them an appropriat...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20175

    authors: Hensley HH,Chang WC,Clapper ML

    更新日期:2004-09-01 00:00:00

  • Proton high-resolution magic angle spinning NMR analysis of fresh and previously frozen tissue of human prostate.

    abstract::The previously observed improvement in spectral resolution of tissue proton NMR with high-resolution magic angle spinning (HRMAS) was speculated to be due largely to freeze-thawing artifacts resulting from tissue storage. In this study, 12 human prostate samples were analyzed on a 14.1T spectrometer at 3 degrees C, wi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10645

    authors: Wu CL,Taylor JL,He W,Zepeda AG,Halpern EF,Bielecki A,Gonzalez RG,Cheng LL

    更新日期:2003-12-01 00:00:00

  • Utilization of an intra-oral diamagnetic passive shim in functional MRI of the inferior frontal cortex.

    abstract::Due to the presence of gross magnetic susceptibility artifacts, functional MRI (fMRI) has proved problematic in studies of the human inferior frontal cortex (IFC). There is a strong desire, therefore, to employ techniques that mitigate susceptibility artifacts in the IFC while preserving the imaging parameters of an f...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10626

    authors: Wilson JL,Jezzard P

    更新日期:2003-11-01 00:00:00

  • High resolution hyperpolarized 13 C MRSI using SPICE at 9.4T.

    abstract:PURPOSE:To test the feasibility of using the SPICE (SPectroscopic Imaging by exploiting spatiospectral CorrElation) technique, which uses the partial separability of spectroscopic data, for high resolution hyperpolarized (HP) 13 C spectroscopic imaging. METHODS:Numerical simulations were performed to investigate the i...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27061

    authors: Lee H,Song JE,Shin J,Joe E,Joo CG,Choi YS,Song HT,Kim DH

    更新日期:2018-08-01 00:00:00

  • Perfusion imaging using dynamic arterial spin labeling (DASL).

    abstract::Recently, a technique based on arterial spin labeling, called dynamic arterial spin labeling (DASL (Magn Reson Med 1999;41:299-308)), has been introduced to measure simultaneously the transit time of the labeled blood from the labeling plane to the exchange site, the longitudinal relaxation time of the tissue, and the...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1136

    authors: Barbier EL,Silva AC,Kim SG,Koretsky AP

    更新日期:2001-06-01 00:00:00

  • Visualization of free radical reactions in an aqueous sample irradiated by 290 MeV carbon beam.

    abstract::The detection of free radical reactions in a gelatin sample irradiated by a heavy-ion beam was tested using electron paramagnetic resonance (EPR) spectroscopic and MRI methods. Geometry and the amount of free radical generation in a sample are described. A reaction mixture containing glutathione and a nitroxyl radical...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21958

    authors: Matsumoto K,Nagata K,Yamamoto H,Endo K,Anzai K,Aoki I

    更新日期:2009-05-01 00:00:00

  • Arrays of mutually coupled receiver coils: theory and application.

    abstract::Specialized receiver coils having a small sensitive region can provide an improvement in SNR for MR imaging and spectroscopy, at the expense of limiting the usable field of view. This work presents a technique for designing coil arrays that allows the size and location of the sensitive region to be selected remotely. ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910170128

    authors: Wright SM,Magin RL,Kelton JR

    更新日期:1991-01-01 00:00:00

  • MRI relaxation fluctuations in acute reperfused hemorrhagic infarction.

    abstract::MRI evaluations of intramyocardial hemorrhage in acute infarction have relied on T(2) and T(2)(*) shortening only. We propose a more comprehensive evaluation of hemorrhagic infarction based on the concept that fluctuations in T(2) and T(1) relaxation in acute reperfused infarction will reflect transient edema and hemo...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21079

    authors: Foltz WD,Yang Y,Graham JJ,Detsky JS,Wright GA,Dick AJ

    更新日期:2006-12-01 00:00:00

  • Optimization and validation of accelerated golden-angle radial sparse MRI reconstruction with self-calibrating GRAPPA operator gridding.

    abstract:PURPOSE:Golden-angle radial sparse parallel (GRASP) MRI reconstruction requires gridding and regridding to transform data between radial and Cartesian k-space. These operations are repeatedly performed in each iteration, which makes the reconstruction computationally demanding. This work aimed to accelerate GRASP recon...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27030

    authors: Benkert T,Tian Y,Huang C,DiBella EVR,Chandarana H,Feng L

    更新日期:2018-07-01 00:00:00

  • Bayesian inference of hemodynamic changes in functional arterial spin labeling data.

    abstract::The study of brain function using MRI relies on acquisition techniques that are sensitive to different aspects of the hemodynamic response contiguous to areas of neuronal activity. For this purpose different contrasts such as arterial spin labeling (ASL) and blood oxygenation level dependent (BOLD) functional MRI tech...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21039

    authors: Woolrich MW,Chiarelli P,Gallichan D,Perthen J,Liu TT

    更新日期:2006-10-01 00:00:00

  • SSFP-based MR thermometry.

    abstract::Of the various techniques employed to quantify temperature changes by MR, proton resonance frequency (PRF) shift-based phase-difference imaging (PDI) is the most accurate and widely used. However, PDI is associated with various artifacts. Motivated by these limitations, we developed a new method to monitor temperature...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20231

    authors: Paliwal V,El-Sharkawy AM,Du X,Yang X,Atalar E

    更新日期:2004-10-01 00:00:00

  • MR microimaging of articular cartilage and contrast enhancement by manganese ions.

    abstract::Saline solutions of manganese ions (Mn2+) were used as articular contrast agents in magnetic resonance microscopy (9.4 T) of cartilage of chicken femoral condyles and pig temporomandibular joints. The diffusion of Mn2+ from the articular surface into the cartilage matrix led to a strong contrast enhancement in the car...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910240114

    authors: Kusaka Y,Gründer W,Rumpel H,Dannhauer KH,Gersonde K

    更新日期:1992-03-01 00:00:00

  • Shaped saturation with inherent radiofrequency-power-efficient trajectory design in parallel transmission.

    abstract:PURPOSE:A target-pattern-driven (TD) trajectory design is introduced in combination with parallel transmit (pTX) radiofrequency (RF) pulses to provide localized suppression of unwanted signals. The design incorporates target-pattern and B1+ information to adjust denser sampling and coverage in k-space regions where the...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25016

    authors: Schneider R,Haueisen J,Pfeuffer J

    更新日期:2014-10-01 00:00:00

  • FLAIR imaging using nonselective inversion pulses combined with slice excitation order cycling and k-space reordering to reduce flow artifacts.

    abstract::High-signal artifacts produced by cerebrospinal fluid (CSF) flow can adversely affect fluid-attenuated inversion recovery (FLAIR) imaging of the brain and spinal cord. This study explores the use of a nonslice-selective inversion pulse to eliminate CSF flow artifacts together with a technique called "K-space Reordered...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1198

    authors: Herlihy AH,Oatridge A,Curati WL,Puri BK,Bydder GM,Hajnal JV

    更新日期:2001-08-01 00:00:00

  • Unambiguous assignment of the H3S and H3R deuterations of cerebral (2-13C) glutamate by 13C NMR at 18.8 Tesla.

    abstract::We used high-field (13)C NMR (18.8 T) to assign unambiguously the isotopic shifts induced by the deuterium substitutions of the H3(proR) and H3(proS) hydrogens of (2-(13)C) glutamate in extracts of the brain from deuterated animals. Monodeuterated H3R or H3S glutamate diastereoisomers were produced stereospecifically ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22277

    authors: Rodrigues TB,Violante IR,Cerdán S

    更新日期:2010-04-01 00:00:00

  • MRI quantitative myocardial perfusion with compartmental analysis: a rest and stress study.

    abstract::K1 (first-order transfer constant from arterial plasma to myocardium for Gd-DTPA) and Vd (distribution volume of Gd-DTPA in myocardium) were measured in vivo in a canine model (n = 5) using MRI-derived myocardial perfusion curves and a compartmental model. Perfusion curves were obtained after a bolus injection of Gd-D...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910380618

    authors: Vallée JP,Sostman HD,MacFall JR,Wheeler T,Hedlund LW,Spritzer CE,Coleman RE

    更新日期:1997-12-01 00:00:00

  • Contrast-enhanced MRI of brown adipose tissue after pharmacological stimulation.

    abstract::A non-invasive method for studying the modifications induced in lipid depots by hormonal stimulation could extend knowledge of adipose tissues. We studied the effect of adrenergic stimulation on interscapular brown adipose tissue (IBAT) of rats using contrast-enhanced MRI. Controls and rats pre-treated with adrenaline...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20851

    authors: Sbarbati A,Cavallini I,Marzola P,Nicolato E,Osculati F

    更新日期:2006-04-01 00:00:00

  • 4D radial coronary artery imaging within a single breath-hold: cine angiography with phase-sensitive fat suppression (CAPS).

    abstract::Coronary artery data acquisition with steady-state free precession (SSFP) is typically performed in a single frame in mid-diastole with a spectrally selective pulse to suppress epicardial fat signal. Data are acquired while the signal approaches steady state, which may lead to artifacts from the SSFP transient respons...

    journal_title:Magnetic resonance in medicine

    pub_type: 临床试验,杂志文章

    doi:10.1002/mrm.20627

    authors: Park J,Larson AC,Zhang Q,Simonetti O,Li D

    更新日期:2005-10-01 00:00:00

  • Sliding time of flight: sliding time of flight MR angiography using a dynamic image reconstruction method.

    abstract:PURPOSE:To obtain three-dimensional (3D) MR angiography having high contrast between vessel and stationary background tissue, a novel technique called sliding time of flight (TOF) is proposed. METHODS:The proposed method relies on the property that flow-related enhancement (FRE) is maximized at the blood-entering slic...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25215

    authors: Choi J,Seo H,Lim Y,Han Y,Park H

    更新日期:2015-03-01 00:00:00

  • Manganese-enhanced MRI of salivary glands and head and neck tumors in living subjects.

    abstract::Manganese-enhanced MRI has previously been used for visualization of brain architecture and functional mapping of neural pathways. The present work investigated the potential of manganese-enhanced MRI for noninvasive imaging of salivary glands in living subjects. Marked shortening of T(1) was observed in salivary glan...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22452

    authors: Seshadri M,Hoy A

    更新日期:2010-09-01 00:00:00

  • On the calculation of magnetization slice profiles for NMR imaging and in vivo spectroscopy.

    abstract::When developing new techniques for NMR imaging and in vivo spectroscopy it is a major advantage to be able to calculate the magnetization slice profiles, at any point during a pulse sequence in the presence of a field gradient. While this has frequently been done by treating the problem as a number of discrete resonan...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910050511

    authors: Bulsing JM,Galloway GJ,Brereton IM,Doddrell DM

    更新日期:1987-11-01 00:00:00