Abstract:
:Focused ultrasound heating of ex vivo bovine kidney and liver was monitored using magnetic resonance imaging (MRI) to investigate the quantitative relationship between time-dependent temperature elevations and altered contrast in MR images due to thermal coagulation. Proton resonance frequency shift MR thermometry was performed during heating at 10 sec intervals (single-slice fast spoiled GRASS [FSPGR], theta/TE/TR 30 degrees/11/39 msec, field of view 8 cm, 256 x 256, 3 mm slice thickness, 1 NEX); post-heating MR images were T1-weighted (3D-FSPGR, theta/TE/TR 60 degrees/25/200 msec, 1 mm slice thickness, 3 NEX). Analysis of the resulting temperature versus time data using the Arrhenius relationship and a simple binary discrimination model showed that thermal coagulation occurred with heating at approximately 54 degrees C for 10 sec in both tissues and could be predicted with approximately 625 microm spatial resolution. These results suggest that quantitative MR guidance of thermal coagulation therapy is feasible, and they provide information useful for designing future investigations in vivo.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Graham SJ,Chen L,Leitch M,Peters RD,Bronskill MJ,Foster FS,Henkelman RM,Plewes DBdoi
10.1002/(sici)1522-2594(199902)41:2<321::aid-mrm16subject
Has Abstractpub_date
1999-02-01 00:00:00pages
321-8issue
2eissn
0740-3194issn
1522-2594pii
10.1002/(SICI)1522-2594(199902)41:2<321::AID-MRM16journal_volume
41pub_type
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更新日期:2011-06-01 00:00:00
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abstract:PURPOSE:The correlation between glutamine metabolism and oncogene expression in cancers has led to a renewed interest in the role of glutamine in cancer cell survival. Hyperpolarized [5-(13) C]glutamine is evaluated as a potential biomarker for noninvasive metabolic measurements of drug response in prostate cancer cell...
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