Abstract:
:Surgical specimens from 22 patients with infiltrating ductal carcinoma of the breast were analyzed by high-resolution 1H NMR spectroscopy at 80 and 300 MHz. Results were compared with those obtained from 9 benign (proliferative dysplasia without atypia) breast samples. NMR spectra at 80 MHz showed well-resolved water and lipid peaks so it was possible to calculate specific T1 and T2 relaxation times. The longitudinal T1 relaxation process of the water was found to be properly represented by a monoexponential function, whereas the transverse T2 decay was well accounted for by a biexponential model. Relaxation time measurements of the water were found to be a valuable tool in breast tissue characterization, in particular (a) mean T1 values from malignant and control populations are well distinguished (P less than 0.0008); (b) mean T2 values of both fast and slow components from the two populations are statistically different (P less than 0.0001) and no overlap exists in the distributions of the second component. Three-hundred-megahertz spectra allowed a detailed analysis of the lipidic component of the sample: malignant tumors were found to present in the region 1.3-1.2 ppm a species characterized by a very slow transverse relaxation time (T2 = 200-1000 ms).
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Bradamante S,Barchiesi E,Pilotti S,Borasi Gdoi
10.1002/mrm.1910080407subject
Has Abstractpub_date
1988-12-01 00:00:00pages
440-9issue
4eissn
0740-3194issn
1522-2594journal_volume
8pub_type
杂志文章abstract::Half k-space gradient-recalled echo-planar imaging (GR-EPI) is discussed in detail. T2* decay during full k-space GR-EPI gives rise to unequal weighting of the lines of k-space, loss of signal intensity at the center of k-space, and a point-spread function that limits resolution. In addition, the long readout time for...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910400517
更新日期:1998-11-01 00:00:00
abstract::The shells trajectory is a 3D data acquisition method with improved efficiency compared to Cartesian sampling. It is a true center-out trajectory that does not repeatedly resample the center of k-space, and also offers advantages for motion correction. This work demonstrates that k-space undersampling can be combined ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20977
更新日期:2006-09-01 00:00:00
abstract:PURPOSE:The oxygen extraction fraction (OEF) is an important biomarker for tissue-viability. MRI enables noninvasive estimation of the OEF based on the blood-oxygenation-level-dependent (BOLD) effect. Quantitative OEF-mapping is commonly applied using least-squares regression (LSR) to an analytical tissue model. Howeve...
journal_title:Magnetic resonance in medicine
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更新日期:2018-02-01 00:00:00
abstract:PURPOSE:We demonstrate the feasibility of MRI with missing-pulse steady-state free precession (MP-SSFP) in a 4T magnet with artificially degraded homogeneity. METHODS:T1 , T2 , and diffusion contrast of MP-SSFP was simulated with constant and alternate radiofrequency (RF) phase using an extended phase graph. To valida...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28469
更新日期:2021-02-01 00:00:00
abstract:PURPOSE:Magnetization transfer ratio (MTR) histograms are used widely for the assessment of diffuse pathological changes in the brain. For broad clinical application, MTR scans should not only be fast, but confounding factors should also be minimized for high reproducibility. To this end, a 1-minute whole-brain spiral ...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.28618
更新日期:2020-12-08 00:00:00
abstract::Proton magnetic resonance spectroscopy ((1)H MRS) was used to determine brain temperature in healthy volunteers. Partially water-suppressed (1)H MRS data sets were acquired at 3T from four different gray matter (GM)/white matter (WM) volumes. Brain temperatures were determined from the chemical-shift difference betwee...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21100
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:To determine whether neurochemical concentrations obtained at two MRI sites using clinical 3T scanners can be pooled when a highly optimized, nonvendor short-echo, single-voxel proton MRS pulse sequence is used in conjunction with identical calibration and quantification procedures. METHODS:A modified semi-LAS...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.25295
更新日期:2015-05-01 00:00:00
abstract::The proton exchange rates between water and the hydroxyl protons of threonine, serine, tyrosine, the amino protons of lysine, and the guanidinium protons of arginine were measured in the pH range 0.5 to 8.5 and for the temperatures 4 degrees C, 10 degrees C, 20 degrees C, 30 degrees C, and 36 degrees C. The intrinsic ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910350106
更新日期:1996-01-01 00:00:00
abstract::Transmit and receive RF coil arrays have proven to be particularly beneficial for ultra-high-field MR. Transmit coil arrays enable such techniques as B(1) (+) shimming to substantially improve transmit B(1) homogeneity compared to conventional volume coil designs, and receive coil arrays offer enhanced parallel imagin...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.22413
更新日期:2010-06-01 00:00:00
abstract::The purpose of this study is (1) to determine the correlation between T(1rho) and T(2) and degenerative grade in intervertebral discs using in vivo 3.0-T MRI, and (2) to determine the association between T(1rho) and T(2) and clinical findings as quantified by the SF-36 Questionnaire and Oswestry Disability Index. Sixt...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.22362
更新日期:2010-05-01 00:00:00
abstract::The manufacturing of intravascular imaging coils poses several challenges. Due to their size, it can be difficult to incorporate local matching networks and signal amplifiers. The goal of this study is to investigate tuning and amplification strategies for intravascular coils and to assess the signal-to-noise benefits...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24134
更新日期:2012-11-01 00:00:00
abstract::Noninvasive investigation of aldose reductase activities in rat testis was performed using 3-fluoro-3-deoxy-D-glucose (3-FDG) and nuclear magnetic resonance (NMR) spectroscopy/imaging. Quantitative determination of testis aldose reductase activities, expressed as the sorbitol index, showed a value similar to that of b...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910290417
更新日期:1993-04-01 00:00:00
abstract::An eight-channel receive-only brain coil and table-top detunable volume transmit coil were developed and tested at 7 T for human imaging. Optimization of this device required attention to sources of interaction between the array elements, between the transmit and receive coils and minimization of common mode currents ...
journal_title:Magnetic resonance in medicine
pub_type: 临床试验,杂志文章
doi:10.1002/mrm.20547
更新日期:2005-07-01 00:00:00
abstract::Cerebral metabolite concentrations and water content were measured by means of localized proton magnetic resonance spectroscopy in 50 children, while metabolite peak ratios in short echo time spectra were evaluated in 173 examinations. Normative curves for normal development were established for two cerebral locations...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910300405
更新日期:1993-10-01 00:00:00
abstract::Human cardiac 31P nuclear magnetic resonance (NMR) spectra are usually quantified in relative terms, i.e., the ratio of metabolite signals is calculated. If 31P NMR spectroscopy of the heart is to emerge as a clinically relevant diagnostic modality, reliable quantification of absolute concentrations of 31P metabolites...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199904)41:4<657::aid-mrm3>
更新日期:1999-04-01 00:00:00
abstract:PURPOSE:Dynamic glucose-enhanced (DGE)-MRI based on chemical exchange-sensitive MRI, that is, glucoCEST and gluco-chemical exchange-sensitive spin-lock (glucoCESL), is intrinsically prone to motion-induced artifacts because the final DGE contrast relies on the difference of images, which were acquired with a time gap o...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28112
更新日期:2020-07-01 00:00:00
abstract::In this study, the precision and accuracy of a new method for measuring axial rotations of the lumbar vertebrae, which are thought to be increased in patients with degenerative spinal instability, were estimated. A standard image registration algorithm involving a user-selected center of rotation was adapted for this ...
journal_title:Magnetic resonance in medicine
pub_type: 临床试验,杂志文章
doi:10.1002/mrm.10319
更新日期:2002-12-01 00:00:00
abstract::A single slice of z-magnetization is used to generate high-speed images. The slice selection step is achieved using two sin-sinc pulses. This procedure eliminates the need for continual slice gradient reversal, a requirement for the FLASH technique. The RAPID imaging method has less inherent T1 and/or T2 dependence th...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910050213
更新日期:1987-08-01 00:00:00
abstract:PURPOSE:This study aims to identify work-related and personal factors associated with workers' exposure to static magnetic fields (SMF) and motion-induced time-varying magnetic fields (TVMF) from MRI scanners. METHODS:Measurements of personal exposure to SMF and TVMF were performed among MRI staff during 439 work shif...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.25720
更新日期:2016-05-01 00:00:00
abstract::The design of a piezoelectric-controlled trimmer capacitor and its use as a tuning element of an MRI surface coil at 63.8 MHz are described. It is found that image quality does not depend strongly on match of the coil to the transmission line but that tuning can be a significant factor. The work is intended to lead ev...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910120106
更新日期:1989-10-01 00:00:00
abstract::In an effort to develop MRI methods for the evaluation of tumor angiogenesis (new blood vessel formation), MRI-derived cerebral blood volume (CBV) information has been compared to histologic measures of microvessel density (MVD). Although MVD is a standard marker of angiogenesis, it is not a direct correlate of the vo...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1252
更新日期:2001-10-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1102
更新日期:2001-05-01 00:00:00
abstract:PURPOSE:The purpose of this study was to investigate the feasibility of in vivo imaging of human pancreatic ductal cells by OATP1B3 reporter gene under MRI. METHODS:A human cell line (PANC-1) derived from the pancreatic ductal epithelium was used in this study. After transduction of OATP1B3, the cellular physiological...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27749
更新日期:2019-08-01 00:00:00
abstract::Functional MR imaging (fMRI) of activation in the brain is one of the more demanding applications required of an NMR imaging instrument. Since the signal changes in activation imaging are quite small, any instrumental variations can easily compromise the fMRI contrast. The authors describe a simple method for measurin...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910360422
更新日期:1996-10-01 00:00:00
abstract::MRS has considerable potential for the measurement of drug pharmacokinetics in vivo. In this study single- and double-resonance (31)P MRS was used to investigate the biodistribution, pharmacokinetics, and metabolism of ifosfamide following administration of 500 mg/kg ifosfamide in guinea pigs. (1)H-decoupling was foun...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10540
更新日期:2003-08-01 00:00:00
abstract::A combined carbogen ultrasmall superparamagnetic iron oxide (USPIO) imaging protocol was developed and applied in vivo in two murine colorectal tumor xenograft models, HCT116 and SW1222, with established disparate vascular morphology, to investigate whether additional information could be extracted from the combinatio...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22779
更新日期:2011-07-01 00:00:00
abstract::We have demonstrated that echo-planar imaging can be used to produce high-quality snapshot images of the human fetus in utero in a fraction of a second. These images are free of motional artifact or blurring and allow detailed depiction of fetal structures in normal and pathological pregnancies. ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910130214
更新日期:1990-02-01 00:00:00
abstract:PURPOSE:To validate an automatic algorithm for offline T2* measurements, providing robust, vendor-independent T2*, and uncertainty estimates for iron load quantification in the heart and liver using clinically available imaging sequences. METHODS:A T2* region of interest (ROI)-based algorithm was developed for robustn...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.25767
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:To demonstrate how triple diffusion encoding (TDE) MRI can be applied to separately estimate the intra-axonal and extra-axonal diffusion tensors in white matter (WM). METHODS:Using a TDE pulse sequence with an axially symmetric b-matrix, diffusion MRI data were acquired at 3T for 3 healthy adults with an axial...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28084
更新日期:2020-06-01 00:00:00
abstract::Lactate is a key metabolite and its rates of cellular uptake and release, its production rates from glucose and glycogen, and its interconversion rate with pyruvate are important determinants of cellular energy production. If lactate precursors such as pyruvate and glucose are labeled appropriately with (13)C, (1)H NM...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20075
更新日期:2004-06-01 00:00:00