Abstract:
:The proton T(1) was measured at 132 μT in ex vivo prostate tissue specimens from radical prostatectomies of 35 patients with prostate cancer. Each patient provided two specimens. The NMR and MRI measurements involved proton repolarization, a field of typically 150 mT and detection of the 5.6-kHz signal with a superconducting quantum interference device. Values of T(1) varied from 41 to 86 ms. Subsequently, the percentages of tissue types were determined histologically. The theoretical image contrast is quantified for each case by δ = [1 - T(1) (more cancer)/T(1) (less cancer)]. A linear fit of δ versus difference in percentage cancer yields T(1) (100% cancer)/T(1) (0% cancer) = 0.70 ± 0.05 with correlation coefficient R(2) = 0.30. Two-dimensional T(1) maps for four specimens demonstrate variation within a single specimen. These results suggest that MR images with T(1) contrast established at ultra-low fields may discriminate prostate cancer from normal prostate tissue in vivo without a contrast agent.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Busch S,Hatridge M,Mößle M,Myers W,Wong T,Mück M,Chew K,Kuchinsky K,Simko J,Clarke Jdoi
10.1002/mrm.24177subject
Has Abstractpub_date
2012-04-01 00:00:00pages
1138-45issue
4eissn
0740-3194issn
1522-2594journal_volume
67pub_type
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