Abstract:
:19F NMR imaging of the perfluorocarbon emulsion Fluosol has been used to study regional variations in oxygen tension in rat liver and spleen. We have used the linear dependence of spin lattice relaxation rate (1/T1) on the partial oxygen pressure (pO2) of Fluosol to determine the oxygen tension in the reticuloendothelial system (RES) of the liver and spleen of male Sprague-Dawley rats which have received serial infusions of Fluosol. Oxygen tension maps have been computed from 19F NMR images using a calibration obtained for Fluosol in vitro at 37.5 degrees C. The spatial resolution of the pO2 maps computed using this technique is 1.2 x 1.2 mm in 3-mm thick slices. Calculations from in vivo pO2 maps indicate an average change in the median pO2 of the RES from 118 to 80 mmHg for (n = 7) rats breathing 95% O2 and 5% CO2 (carbogen) and air, respectively.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Holland SK,Kennan RP,Schaub MM,D'Angelo MJ,Gore JCdoi
10.1002/mrm.1910290405subject
Has Abstractpub_date
1993-04-01 00:00:00pages
446-58issue
4eissn
0740-3194issn
1522-2594journal_volume
29pub_type
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