Understanding and optimizing the amplitude modulated control for multiple-slice continuous arterial spin labeling.

Abstract:

:Multiple-slice perfusion imaging by continuous arterial spin labeling (CASL) is made possible by amplitude modulation (AM) of the labeling RF pulse, but perfusion sensitivity is reduced relative to the single-slice technique. A computer model of the Bloch equations for velocity driven adiabatic fast passage was developed to elucidate the compromised sensitivity to perfusion of the AM control technique for CASL. Calculations were performed over ranges of RF pulse amplitude, B1; magnetic field gradient, G; phase, phi, and frequency, f, of the modulation function; velocity, v, and relaxation times, T1 and T2, of blood. It was found that unless f>2piB1, phi determines the performance of the AM control; excessively high B1 or v reduces the efficiency of the AM control; and T1 relaxation dominates if f is too great. In vivo, in rat brain (n=5) at 2.35 T, the sensitivity of the AM technique to perfusion was 70% of the sensitivity of single-slice CASL.

journal_name

Magn Reson Med

authors

Utting JF,Thomas DL,Gadian DG,Helliar RW,Lythgoe MF,Ordidge RJ

doi

10.1002/mrm.20604

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

594-604

issue

3

eissn

0740-3194

issn

1522-2594

journal_volume

54

pub_type

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