Abstract:
:Intermolecular double quantum coherences (iDQCs), signals that result from simultaneous transitions of two or more separated spins, are known to produce images that are highly sensitive to subvoxel structure, particularly local anisotropy. Here we demonstrate how iDQCs signal can be used to efficiently detect the anisotropy created in breast tumor tissues and prostate tumor tissues by targeted (LHRH-conjugated) superparamagnetic nanoparticles (SPIONs), thereby distinguishing the necrotic area from the surrounding tumor tissue.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Branca RT,Chen YM,Mouraviev V,Galiana G,Jenista ER,Kumar C,Leuschner C,Warren WSdoi
10.1002/mrm.21925subject
Has Abstractpub_date
2009-04-01 00:00:00pages
937-43issue
4eissn
0740-3194issn
1522-2594journal_volume
61pub_type
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910380608
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abstract:PURPOSE:To validate an automatic algorithm for offline T2* measurements, providing robust, vendor-independent T2*, and uncertainty estimates for iron load quantification in the heart and liver using clinically available imaging sequences. METHODS:A T2* region of interest (ROI)-based algorithm was developed for robustn...
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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