iDQC anisotropy map imaging for tumor tissue characterization in vivo.

Abstract:

:Intermolecular double quantum coherences (iDQCs), signals that result from simultaneous transitions of two or more separated spins, are known to produce images that are highly sensitive to subvoxel structure, particularly local anisotropy. Here we demonstrate how iDQCs signal can be used to efficiently detect the anisotropy created in breast tumor tissues and prostate tumor tissues by targeted (LHRH-conjugated) superparamagnetic nanoparticles (SPIONs), thereby distinguishing the necrotic area from the surrounding tumor tissue.

journal_name

Magn Reson Med

authors

Branca RT,Chen YM,Mouraviev V,Galiana G,Jenista ER,Kumar C,Leuschner C,Warren WS

doi

10.1002/mrm.21925

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

937-43

issue

4

eissn

0740-3194

issn

1522-2594

journal_volume

61

pub_type

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