Early changes in water diffusion, perfusion, T1, and T2 during focal cerebral ischemia in the rat studied at 8.5 T.

Abstract:

:The time evolution of water diffusion, perfusion, T1, and T2 is investigated at high magnetic field (8.5 T) following permanent middle cerebral artery occlusion in the rat. Cerebral blood flow maps were obtained using arterial spin tagging. Although the quantitative perfusion measurements in ischemic tissue still pose difficulties, the combined perfusion and diffusion data nevertheless distinguish between a "moderately affected area," with reduced perfusion but normal diffusion; and a "severely affected area," in which both perfusion and diffusion are significantly reduced. Two novel magnetic resonance imaging observations are reported, namely, a decrease in T2 and an increase in T1, both within the first few minutes of ischemia. The rapid initial decrease in T2 is believed to be associated with an increase in deoxyhemoglobin levels, while the initial increase in T1 may be related to several factors, such as flow effects, an alteration in tissue oxygenation, and changes in water environment.

journal_name

Magn Reson Med

authors

Calamante F,Lythgoe MF,Pell GS,Thomas DL,King MD,Busza AL,Sotak CH,Williams SR,Ordidge RJ,Gadian DG

doi

10.1002/(sici)1522-2594(199903)41:3<479::aid-mrm9>

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

479-85

issue

3

eissn

0740-3194

issn

1522-2594

pii

10.1002/(SICI)1522-2594(199903)41:3<479::AID-MRM9>

journal_volume

41

pub_type

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