Quantification of the extraction fraction for gadopentetate across breast cancer capillaries.

Abstract:

:To quantify the extraction fraction, E, for gadopentetate across tumor capillaries, R3230 adenocarcinomas were implanted in the mammary fat pads of seven rats. The value of E was determined by using a two-compartment tissue model in which the endothelial transfer coefficient, K(PS) (ml x min(-1) x cc(-1) of tissue), was estimated from the model fitted to changes in R1 relaxation time (deltaR1; s(-1)) measured by dynamic three-dimensional spoiled gradient recalled magnetic resonance imaging after injection of 0.1 mmol x kg(-1) of gadopentetate dimeglumine. The plasma flow rate through the tumor capillaries, Fp, (ml x min(-1) x g(-1) of tissue), was independently measured with fluorescent microspheres. E could be calculated by the relationship, E = K(PS)/Fp. The mean E for gadopentetate in the R3230 tumor was 0.197 +/- 0.118 with a range of 0.123-0.454. The relatively small mean value of E for gadopentetate allows a fair approximation of the permeability surface area product by K(PS) in this R3230 tumor model.

journal_name

Magn Reson Med

authors

Daldrup HE,Shames DM,Husseini W,Wendland MF,Okuhata Y,Brasch RC

doi

10.1002/mrm.1910400406

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

537-43

issue

4

eissn

0740-3194

issn

1522-2594

journal_volume

40

pub_type

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