Abstract:
:We exploit the intrinsic difference in magnetic resonance spin-spin relaxation time, T2, between water associated with myelin sheaths and water in other central nervous system tissue in order to measure myelin water content within any region of an image or to generate indirectly a myelin map of the brain. In normal volunteers, myelin water maps give the expected myelin distribution. In multiple sclerosis patients, lesions exhibit different myelin water contents providing insight into the demyelination process unavailable from conventional magnetic resonance images. In vivo myelin measurement has important applications in the clinical management of multiple sclerosis and other white matter diseases.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
MacKay A,Whittall K,Adler J,Li D,Paty D,Graeb Ddoi
10.1002/mrm.1910310614subject
Has Abstractpub_date
1994-06-01 00:00:00pages
673-7issue
6eissn
0740-3194issn
1522-2594journal_volume
31pub_type
杂志文章abstract::In a systematic study on the interdependence of linewidth, signal-to-noise ratio (SNR), and spatial resolution in 3D proton spectroscopic imaging ((1)H-SI) at 3 T, we demonstrate reduced linewidths with increased spatial resolution due to reduced magnetic inhomogeneity within the brain. High-precision quantitative dat...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10377
更新日期:2003-02-01 00:00:00
abstract:PURPOSE:Waveguide elastography (WGE) combines magnetic resonance elastography (MRE), diffusion tensor imaging (DTI), and anisotropic inversions for a determination of the elastic properties of white matter. Previously, the method evaluated the anisotropic elastic properties of the corticospinal tracts (CSTs) of healthy...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25067
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:To accelerate whole-heart three-dimension MR angiography (MRA) by using a variable-density Poisson-disc undersampling pattern and a compressed sensing (CS) reconstruction algorithm, and compare the results with sensitivity encoding (SENSE). METHODS:For whole-heart MRA, a prospective variable-density Poisson-di...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26730
更新日期:2018-02-01 00:00:00
abstract::T2 measurements of 31P NMR signals of ATP using the Hahn 90 degrees-180 degrees spin-echo sequence imply difficulties whenever the 180 degrees pulse angle is not completely perfect. The reason for this finding is the crucial influence of the J-couplings of the ATP signals which result in intensity modulations and cons...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910300122
更新日期:1993-07-01 00:00:00
abstract::Leakage of Gd-DTPA through a defective blood-brain barrier is measured quantitatively using dynamic MRI scanning, in which repeated scans are made after a bolus injection. Image registration artifacts are minimized; a dose of 0.1 mM/kg and an IR sequence enable enhancement to be measured quantitatively. The triexponen...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910170208
更新日期:1991-02-01 00:00:00
abstract::Alternate methods to quantify mitochondrial activity or function have been extensively used for studying insulin resistance and type 2 diabetes mellitus, namely saturation transfer and phosphocreatine (PCr) recovery. As these methods are in fact determining different parameters, this study aimed to compare saturation ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.23095
更新日期:2012-04-01 00:00:00
abstract::Slowly cycling cells are believed to play a critical role in tumor progression and metastatic dissemination. The goal of this study was to develop a method for in vivo detection of slowly cycling cells. To distinguish these cells from more rapidly proliferating cells that constitute the vast majority of cells in tumor...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22917
更新日期:2011-11-01 00:00:00
abstract::Genetically engineered mouse models provide enormous potential for investigation of the underlying mechanisms of atherosclerotic disease, but noninvasive imaging methods for analysis of atherosclerosis in mice are currently limited. This study aimed to demonstrate the feasibility of MRI to noninvasively visualize athe...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10500
更新日期:2003-07-01 00:00:00
abstract::In numerical analyses of radiofrequency (RF) fields for MRI, RF power is often permitted to radiate out of the problem region. In reality, RF power will be confined by the magnet bore and RF screen enclosing the magnet room. We present numerical calculations at different frequencies for various surface and volume coil...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24244
更新日期:2013-01-01 00:00:00
abstract::The authors introduce several sets of time-efficient gradient waveforms for applying isotropic diffusion weighting in NMR experiments. This creates signal attenuation that depends on the trace of the diffusion tensor and is therefore rotationally invariant. Numerical methods for the calculation of such gradient sets a...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910340202
更新日期:1995-08-01 00:00:00
abstract:PURPOSE:A new approach to design parallel transmit (pTx) head arrays is proposed that integrates transmit radiofrequency pulse designs with electromagnetic modeling of array coil elements. THEORY AND METHODS:An approach to design pTx head arrays is proposed that finds optimal groupings of a large number of coils into ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28068
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:To introduce a new outer volume suppression (OVS) technique that uses a single pulse and rotating gradients to accomplish frequency-swept excitation. This new technique, which is called gradient rotating outer volume excitation (GROOVE), produces a circular or elliptical suppression band rather than suppressing...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25101
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:Myocardial effective relaxation time T2* is commonly regarded as a surrogate for myocardial tissue oxygenation. However, it is legitimate to assume that there are multiple factors that influence T2*. To this end, this study investigates the relationship between T2* and cardiac macromorphology given by left vent...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26312
更新日期:2017-06-01 00:00:00
abstract::The pulse wave velocity (PWV) of aortic blood flow is considered a surrogate for aortic compliance. A new method using phase-contrast (PC)-MRI is presented whereby the spatial and temporal profiles of axial velocity along the descending aorta can be analyzed. Seventeen young healthy volunteers (the YH group), six olde...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21034
更新日期:2006-10-01 00:00:00
abstract:PURPOSE:Applications of dynamic shimming require high field fidelity, and characterizing the shim field dynamics is therefore necessary. Modeling the system as linear and time-invariant, the purpose of this work was to measure the impulse response function with optimal sensitivity. THEORY AND METHODS:Frequency-swept p...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24934
更新日期:2014-08-01 00:00:00
abstract:PURPOSE:Nicotinamide adenine dinucleotide (NAD), in oxidized (NAD(+) ) or reduced (NADH) form, plays key roles in cellular metabolism. Intracellular NAD(+) /NADH ratio represents the cellular redox state; however, it is difficult to measure in vivo. We report here a novel in vivo (31) P MRS method for noninvasive measu...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24859
更新日期:2014-06-01 00:00:00
abstract::It has been suggested that orientational changes in the collagen network of articular cartilage account for the depthwise T2 anisotropy of MRI through the magic angle effect. To investigate the relationship between laminar T2 appearance and collagen organization (anisotropy), bovine osteochondral plugs (N = 9) were T2...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1218
更新日期:2001-09-01 00:00:00
abstract::Quantification of peak velocity is important in the assessment of stenotic flow jets in patients with congenital heart disease. Phase-contrast magnetic resonance underestimates peak velocities. Hence, clinically Doppler ultrasound is used as the reference standard for assessing stenoses. It is possible to accurately m...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24293
更新日期:2012-06-01 00:00:00
abstract::A current limitation of many myocardial tag acquisitions employing SPAMM encoding is the relatively rapid loss of tag contrast over the cardiac cycle. Acquisition schemes that apply line tags produce prolonged tag contrast compared with directly excited grid tags. However, a grid-tag series can be generated by combini...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910370519
更新日期:1997-05-01 00:00:00
abstract:PURPOSE:A direct method of imaging neural activity was simulated to determine typical signal sizes. METHODS:An active bidomain finite-element model was used to estimate approximate perturbations in MR phase data as a result of neural tissue activity, and when an external MR electrical impedance tomography imaging curr...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27351
更新日期:2019-01-01 00:00:00
abstract::The MMQ cell line is a unique prolactin-secreting rat pituitary cell line. MMQ cells entrapped in agarose gel threads are metabolically active, as determined by the uptake and phosphorylation of creatine and the maintenance of high energy phosphates for over 15 h. Forskolin activates the catalytic subunit of adenylyl ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910320507
更新日期:1994-11-01 00:00:00
abstract::Any number of coils can in principle be used simultaneously and independently in magnetic resonance imaging if the mutual inductances are sufficiently small. Surface coils and head or body coils have equal sensitivity at some crossover depth of the order of 6 to 10 cm. Using a 7.5-cm-diameter surface coil that was int...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910060212
更新日期:1988-02-01 00:00:00
abstract::The purpose of the study was to test a newly developed, MR-compatible, liquid nitrogen-cooled cryoprobe. The probe has an outer diameter of 3.5 mm and was specifically developed for percutaneous, MR-guided, interstitial cryotherapy. The probe was inserted percutaneously into the livers of 10 rabbits. The cryotherapy p...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910390304
更新日期:1998-03-01 00:00:00
abstract::A method is presented for the detection of quadrupole splitting in tissue, where the spectral line splittings are typically unobservable. The method used is a study of the rate of rotation of the flip angle as a function of radiofrequency (rf) amplitude. Our results with samples of skeletal muscle and cat brain indica...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910040108
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:Reliable monitoring of tissue nicotinamide adenine dinucleotide (NAD+ ) concentration may provide insights on its roles in normal and pathological aging. In the present study, we report a 1 H MRS pulse sequence for the in vivo, localized 1 H MRS detection of NAD+ from the human brain. METHODS:Studies were carr...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27971
更新日期:2020-03-01 00:00:00
abstract::Pattern recognition techniques (factor analysis and neural networks) were used to investigate and classify human brain tumors based on the 1H NMR spectra of chemically extracted biopsies (n = 118). After removing information from lactate (because of variable ischemia times), unsupervised learning suggested that the sp...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910390604
更新日期:1998-06-01 00:00:00
abstract:PURPOSE:To test and implement a motion-robust and respiratory-resolved 3D Radial Flow framework that addresses the need for rapid, high resolution imaging in neonatal patients with congenital heart disease. METHODS:A 4-point velocity encoding and 3D radial trajectory with double-golden angle ordering was combined with...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27945
更新日期:2020-02-01 00:00:00
abstract::Cortical bone in the mature skeleton has a short T(2)* and produces no detectable signal with conventional MR sequences. A two-dimensional ultrashort echo time (UTE) sequence employing half radio frequency (RF) pulse excitations and radial ramp sampling reduces the effective TE to 8 micros and is capable of detecting ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21397
更新日期:2007-11-01 00:00:00
abstract::The goal of this study was to measure the interindividual reproducibility of glutamate quantification in 1.5-T (1)H MRS of human brains. To determine the effective echo time (TE) for glutamate quantification, spectra from a phantom and 12 participants were obtained with TE = 30, 35, 40, and 144 ms (repetition time (TR...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20387
更新日期:2005-03-01 00:00:00
abstract:PURPOSE:Cross-relaxation of protons with (14) N nuclei in proteins enhances relaxivity in the quadrupolar dip range of typically 2-3 MHz Larmor frequency. The magnitude of these dips was suggested as a means of assessing the degeneracy of articular cartilage during osteoarthritis (OA). However, so far only proteoglycan...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25292
更新日期:2015-05-01 00:00:00