In vivo visualization of myelin water in brain by magnetic resonance.

Abstract:

:We exploit the intrinsic difference in magnetic resonance spin-spin relaxation time, T2, between water associated with myelin sheaths and water in other central nervous system tissue in order to measure myelin water content within any region of an image or to generate indirectly a myelin map of the brain. In normal volunteers, myelin water maps give the expected myelin distribution. In multiple sclerosis patients, lesions exhibit different myelin water contents providing insight into the demyelination process unavailable from conventional magnetic resonance images. In vivo myelin measurement has important applications in the clinical management of multiple sclerosis and other white matter diseases.

journal_name

Magn Reson Med

authors

MacKay A,Whittall K,Adler J,Li D,Paty D,Graeb D

doi

10.1002/mrm.1910310614

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

673-7

issue

6

eissn

0740-3194

issn

1522-2594

journal_volume

31

pub_type

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