Abstract:
:Pattern recognition techniques (factor analysis and neural networks) were used to investigate and classify human brain tumors based on the 1H NMR spectra of chemically extracted biopsies (n = 118). After removing information from lactate (because of variable ischemia times), unsupervised learning suggested that the spectra separated naturally into two groups: meningiomas and other tumors. Principal component analysis reduced the dimensionality of the data. A back-propagation neural network using the first 30 principal components gave 85% correct classification of meningiomas and nonmeningiomas. Simplification by vector rotation gave vectors that could be assigned to various metabolites, making it possible to use or to reject their information for neural network classification. Using scores calculated from the four rotated vectors due to creatine and glutamine gave the best classification into meningiomas and nonmeningiomas (89% correct). Classification of gliomas (n = 47) gave 62% correct within one grade. Only inositol showed a significant correlation with glioma grade.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Maxwell RJ,Martínez-Pérez I,Cerdán S,Cabañas ME,Arús C,Moreno A,Capdevila A,Ferrer E,Bartomeus F,Aparicio A,Conesa G,Roda JM,Carceller F,Pascual JM,Howells SL,Mazucco R,Griffiths JRdoi
10.1002/mrm.1910390604subject
Has Abstractpub_date
1998-06-01 00:00:00pages
869-77issue
6eissn
0740-3194issn
1522-2594journal_volume
39pub_type
杂志文章abstract::Dynamic contrast-enhanced MRI using gadolinium or manganese provides unique characterization of myocardium and its pathology. In this study, an electrocardiography (ECG) triggered saturation recovery Look-Locker method was developed and validated for fast cardiac T(1) mapping in small animal models. By sampling the in...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22544
更新日期:2010-11-01 00:00:00
abstract::MRI of hyperpolarized (129)Xe dissolved in pulmonary tissues, and blood has the potential to offer a new tool for regional evaluation of pulmonary gas exchange and perfusion; however, the extremely short T2* and low magnetization density make it difficult to acquire the image. In this study, an ultrashort echo-time se...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24452
更新日期:2013-07-01 00:00:00
abstract::An arterial spin labeling technique using separate RF labeling and imaging coils was used to obtain multislice perfusion images of the human brain at 3 T. Continuous RF irradiation at a peak power of 0.3 W was applied to the carotid arteries to adiabatically invert spins. Labeling was achieved without producing magnet...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199906)41:6<1093::aid-mrm4
更新日期:1999-06-01 00:00:00
abstract:PURPOSE:To accelerate the acquisition of J-resolved proton magnetic resonance spectroscopic imaging (1 H-MRSI) data for high-resolution mapping of brain metabolites and neurotransmitters. METHODS:The proposed method used a subspace model to represent multidimensional spatiospectral functions, which significantly reduc...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28413
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:To remove nuisance signals (e.g., water and lipid signals) for (1) H MRSI data collected from the brain with limited and/or sparse (k, t)-space coverage. METHODS:A union-of-subspace model is proposed for removing nuisance signals. The model exploits the partial separability of both the nuisance signals and the...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25635
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:To obtain three-dimensional (3D) MR angiography having high contrast between vessel and stationary background tissue, a novel technique called sliding time of flight (TOF) is proposed. METHODS:The proposed method relies on the property that flow-related enhancement (FRE) is maximized at the blood-entering slic...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25215
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:In contrast to conventional linear gradients, gradient coil arrays with arbitrary spatial dependency might experience strong mutual coupling. Although conventional gradient power amplifiers with feedback loop might compensate the effect of coupling, required voltages for the compensation are generally unknown a...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27768
更新日期:2019-09-01 00:00:00
abstract::Hyperpolarized (HP) 129Xe can be dissolved in biologically compatible lipid emulsions while maintaining sufficient polarization for in vivo vascular imaging. For xenon in Intralipid 30%, in vitro spectroscopy at 2 T yielded a chemical shift of 197 +/- 1 ppm with reference to xenon gas, a spin-lattice relaxation time T...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199905)41:5<1058::aid-mrm2
更新日期:1999-05-01 00:00:00
abstract::There is increasing interest in quantitative T(1) mapping techniques for a variety of applications. Several methods for T(1) quantification have been described. The acquisition of two spoiled gradient-echo data sets with different flip angles allows for the calculation of T(1) maps with a high spatial resolution and a...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21776
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:The aim of this work was to quantify the extent of lipid-rich necrotic core (LRNC) and intraplaque hemorrhage (IPH) in atherosclerotic plaques. METHODS:Patients scheduled for carotid endarterectomy underwent four-point Dixon and T1-weighted magnetic resonance imaging (MRI) at 3 Tesla. Fat and R2* maps were gen...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26359
更新日期:2017-07-01 00:00:00
abstract::The combination of cardiac viability and functional information enhances the identification of different heart tissues in the setting of ischemic heart disease. A method has recently been proposed for obtaining black-blood delayed-enhancement (DE) viability images using the stimulated-echo acquisition mode (STEAM) MRI...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21390
更新日期:2007-10-01 00:00:00
abstract:PURPOSE:The diseased myocardium lacks metabolic flexibility and responds to stimuli differently compared with healthy hearts. Here, we report the use of hyperpolarized 13C NMR spectroscopy to detect sudden changes in cardiac metabolism in isolated, perfused rat hearts in response to adrenergic stimulation. METHODS:Met...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25419
更新日期:2015-08-01 00:00:00
abstract::The potential application of gas microbubbles as a unique intravascular susceptibility contrast agent for MRI has not been fully explored. In this study, the MR susceptibility effect of an ultrasound microbubble contrast agent, Optison, was studied with rat liver imaging at 7 T. Optison suspension in two different dos...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20181
更新日期:2004-09-01 00:00:00
abstract::A new fully automatic algorithm for the segmentation of the brain and total intracranial cerebrospinal fluid (CSF) from T(1)-weighted volume MRI scans of the head, called Exbrain v.2, is described. The algorithm was developed in the context of serial intracranial volumetry. A brain mask obtained using a previous versi...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10436
更新日期:2003-05-01 00:00:00
abstract::Unusually high image contrast in vivo magnetic resonance imaging of the brain becomes observable at high magnetic fields when the blood oxygenation level is lowered. The cause of the contrast has been attributed to a magnetic susceptibility effect induced by paramagnetic deoxyhemoglobin in red cells. When the cylinder...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910160103
更新日期:1990-10-01 00:00:00
abstract::The aim of this study was to quantify changes in thoracic aortic wall shear stress (WSS) in asymptomatic patients with Marfan syndrome (MFS) compared with healthy controls. WSS in the thoracic aorta was quantified based on time-resolved 3D phase contrast MRI with three-directional velocity encoding (4D flow MRI, tempo...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24562
更新日期:2013-10-01 00:00:00
abstract::MR techniques have proven their ability to investigate skeletal muscle function in situ. Their benefit in terms of noninvasiveness is, however, lost in animal research, given that muscle stimulation and force output measurements are usually achieved using invasive surgical procedures, thereby excluding repeated invest...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22386
更新日期:2010-07-01 00:00:00
abstract:PURPOSE:To design and demonstrate a new susceptibility-based tracking device with an artifact that can be mechanically turned on and off, thus permitting tracking and imaging at the device tip with limited artifact. METHODS:The magnetic susceptibilities of readily obtainable grades of titanium and graphite were measur...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24899
更新日期:2014-07-01 00:00:00
abstract::Recent in vivo 1H MRS studies of muscle oxygen levels by means of myoglobin (Mb) oxygenation have necessitated an investigation of the possible contamination from deoxy-hemoglobin (Hb). To determine the contribution of Hb in these NMR measurements, we studied the NMR visibility of histidyl N-delta proton of Hb in lyse...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910300616
更新日期:1993-12-01 00:00:00
abstract:PURPOSE:Coil-by-coil reconstruction methods are followed by coil combination to obtain a single image representing a spin density map. Typical coil combination methods, such as square-root sum-of-squares and adaptive coil combining, yield images that exhibit spatially varying modulation of image intensity. Existing pra...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25664
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:Because of short signal lifetimes and respiratory motion, 3D lung MRI is still challenging today. Zero-TE (ZTE) pulse sequences offer promising solutions as they overcome the issue of short T 2 ∗ ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28483
更新日期:2021-02-01 00:00:00
abstract::An approach to efficiently measure three-dimensional velocity vector fields and turbulent kinetic energy of blood flow is presented. Multipoint phase-contrast imaging is used in combination with Bayesian analysis to map both mean and fluctuating velocities over a large dynamic range and for practically relevant signal...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24370
更新日期:2013-05-01 00:00:00
abstract::Dynamic contrast-enhanced (DCE-) MRI is often used to evaluate the response to experimental antiangiogenic therapies in small animal models of cancer. Unfortunately, DCE-MRI studies often require a substantial investment of both time and money to achieve the desired level of statistical significance. Multiple-mouse MR...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21348
更新日期:2007-09-01 00:00:00
abstract::Rapid flow imaging was achieved with a partial field of view (pFOV) spiral motion-encoded technique. The FOV and the acquisition time were reduced by a factor of 2 by undersampling k-space. The pFOV spiral k-space trajectory aliased signals from outside a circular ring whose radius was inversely proportional to the di...
journal_title:Magnetic resonance in medicine
pub_type: 临床试验,杂志文章
doi:10.1002/mrm.20975
更新日期:2006-09-01 00:00:00
abstract::Flow measurement methods for functional MRI (fMRI) are desirable as they are more closely tied to neuronal activity than the commonly used blood oxygenation techniques. In this work we introduce a flow-based functional imaging method. The method, called flow enhancement of signal intensity (FENSI), is an extension of ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21325
更新日期:2007-08-01 00:00:00
abstract::T1 is often ill-determined. This means that an Ernst angle excitation often cannot be precisely defined for the simple pulse and acquire experiment. Here, published 31P T1 values of metabolites in human muscle, liver, heart, and brain are archived, some new data on heart and brain added, and overall confidence interva...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910320120
更新日期:1994-07-01 00:00:00
abstract::Successful radiofrequency (RF) thermal ablation was performed on VX2 tumors implanted in 23 rabbit livers under magnetic resonance (MR) guidance using a C-arm-shaped low-field 0.2 T system. RF application and immediate postprocedure MRI of all animals was performed [T2-weighted, turbo short tau inversion recovery (STI...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199907)42:1<141::aid-mrm19
更新日期:1999-07-01 00:00:00
abstract::An automated retrospective image registration based on mutual information is adapted to a multislice functional magnetic resonance imaging (fMRI) acquisition protocol to provide accurate motion correction. Motion correction is performed by mapping each slice to an anatomic volume data set acquired in the same fMRI ses...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199905)41:5<964::aid-mrm16
更新日期:1999-05-01 00:00:00
abstract:PURPOSE:This study aims to identify work-related and personal factors associated with workers' exposure to static magnetic fields (SMF) and motion-induced time-varying magnetic fields (TVMF) from MRI scanners. METHODS:Measurements of personal exposure to SMF and TVMF were performed among MRI staff during 439 work shif...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25720
更新日期:2016-05-01 00:00:00
abstract::Advances in modern magnetic resonance imaging (MRI) pulse sequences have enabled clinically practical cortical bone imaging. Human cortical bone is known to contain a distribution of T(1) and T(2) components attributed to bound and pore water, although clinical imaging approaches have yet to discriminate bound from po...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24186
更新日期:2012-12-01 00:00:00