Abstract:
:Dynamic contrast-enhanced MRI using gadolinium or manganese provides unique characterization of myocardium and its pathology. In this study, an electrocardiography (ECG) triggered saturation recovery Look-Locker method was developed and validated for fast cardiac T(1) mapping in small animal models. By sampling the initial portion of the longitudinal magnetization recovery curve, high temporal resolution (∼ 3 min) can be achieved at a high spatial resolution (195 × 390 μm2) in mouse heart without the aid of parallel imaging or echo-planar imaging. Validation studies were performed both in vitro on a phantom and in vivo on C57BL/6 mice (n = 6). Our results showed a strong agreement between T(1) measured by saturation recovery Look-Locker and by the standard saturation recovery method in vitro or inversion recovery Look-Locker in vivo. The utility of saturation recovery Look-Locker in dynamic contrast-enhanced MRI studies was demonstrated in manganese-enhanced MRI experiments in mice. Our results suggest that saturation recovery Look-Locker can provide rapid and accurate cardiac T(1) mapping for studies using small animal models.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Li W,Griswold M,Yu Xdoi
10.1002/mrm.22544subject
Has Abstractpub_date
2010-11-01 00:00:00pages
1296-303issue
5eissn
0740-3194issn
1522-2594journal_volume
64pub_type
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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journal_title:Magnetic resonance in medicine
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更新日期:2005-05-01 00:00:00
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