Abstract:
:In a systematic study on the interdependence of linewidth, signal-to-noise ratio (SNR), and spatial resolution in 3D proton spectroscopic imaging ((1)H-SI) at 3 T, we demonstrate reduced linewidths with increased spatial resolution due to reduced magnetic inhomogeneity within the brain. High-precision quantitative data (0.75-0.094 cm(3)) were obtained for all resolutions, enabling the creation of metabolic maps that display details such as the ventricles, sulci, and gyri. High-resolution (1)H-SI allows differences in metabolic ratios to be estimated for anatomically defined regions in gray (GM) and white matter (WM). Seven distinct regions in a healthy brain were anatomically segmented and their metabolic ratios were compared quantitatively. Data from a tumor patient are also presented to demonstrate potential clinical applications. Because of the high resolution, the metabolite ratios could be determined for distinct pathologic regions within the tumor and its surroundings. The method was additionally applied to a patient with patchy Pelizaeus Merzbacher disease (PMD), and compared to single-voxel spectroscopy performed in the same session. High-resolution SI data were demonstrated in our study to allow the direct matching of anatomic and metabolic images. This may enhance the clinical value of (1)H-SI.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Gruber S,Mlynárik V,Moser Edoi
10.1002/mrm.10377subject
Has Abstractpub_date
2003-02-01 00:00:00pages
299-306issue
2eissn
0740-3194issn
1522-2594journal_volume
49pub_type
杂志文章abstract::Flow measurement methods for functional MRI (fMRI) are desirable as they are more closely tied to neuronal activity than the commonly used blood oxygenation techniques. In this work we introduce a flow-based functional imaging method. The method, called flow enhancement of signal intensity (FENSI), is an extension of ...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.21325
更新日期:2007-08-01 00:00:00
abstract::Spatial resolution in 3D breath-hold coronary MR angiography (MRA) is limited by imaging time. The purpose of this work was to investigate the feasibility of improving the spatial resolution of coronary MRA using generalized autocalibrating partially parallel acquisition (GRAPPA) and fast imaging with steady state pre...
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更新日期:2017-07-01 00:00:00
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更新日期:2016-04-01 00:00:00
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更新日期:2016-10-01 00:00:00
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更新日期:2015-03-01 00:00:00
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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更新日期:2016-11-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.10046
更新日期:2002-02-01 00:00:00
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doi:10.1002/mrm.1910400406
更新日期:1998-10-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.25322
更新日期:2014-09-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.20896
更新日期:2006-06-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910210116
更新日期:1991-09-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10713
更新日期:2004-03-01 00:00:00
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更新日期:2007-06-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910370507
更新日期:1997-05-01 00:00:00
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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更新日期:1987-06-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910030221
更新日期:1986-04-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2008-07-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2014-03-01 00:00:00
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.21776
更新日期:2009-01-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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更新日期:1990-07-01 00:00:00