Abstract:
:This study investigated the use of peritoneal dialysis fluid (dialyzate) as a MR contrast agent to visualize the liver structure and peritoneal adhesion in rats at 7 T. Intraperitoneal injection of dialyzate (approximately 0.1 ml/g) yielded excellent and consistent intraperitoneal enhancement that delineated the liver lobular structure in all rats studied (N = 8). It also allowed the MR detection of peritoneal adhesions that were surgically induced. MR measurements of adhesion surface areas correlated well with the postmortem estimations (R = 0.99; N = 6). Dialyzate persisted in the intraperitoneal cavity for up to 2 days. T(1) and T(2) values of undiluted dialyzate were found to be 3017.5 +/- 35.3 ms and 108.4 +/- 2.0 ms, respectively. These findings demonstrated dialyzate-enhanced MRI as a potentially valuable technique to localize certain activities within liver (such as local tumor metastasis), and to monitor therapeutic interventions (e.g., against peritoneal adhesion) in preclinical research using small animal models.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Cheung JS,Guo H,Leung JC,Man K,Lai KN,Wu EXdoi
10.1002/mrm.21506subject
Has Abstractpub_date
2008-05-01 00:00:00pages
1170-4issue
5eissn
0740-3194issn
1522-2594journal_volume
59pub_type
杂志文章abstract:PURPOSE:We sought to develop and test a clinically feasible 1-point Dixon, three-dimensional (3D) radial acquisition strategy to create isotropic 3D MR images of (129)Xe in the airspaces, barrier, and red blood cells (RBCs) in a single breath. The approach was evaluated in healthy volunteers and subjects with idiopathi...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25675
更新日期:2016-04-01 00:00:00
abstract::Transparent pulses are defined by the property of having no net effect on stationary spins, while selectively nutating and dephasing flowing spins. They are derived from the inverse scattering transform, a nonlinear extension of the inverse Fourier transform. They can be used as presaturation pulses to suppress select...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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journal_title:Magnetic resonance in medicine
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更新日期:2004-04-01 00:00:00
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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更新日期:2003-05-01 00:00:00
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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更新日期:2013-06-01 00:00:00
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更新日期:2015-11-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:1998-04-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910030122
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journal_title:Magnetic resonance in medicine
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更新日期:2009-02-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2002-06-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.21789
更新日期:2008-12-01 00:00:00
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doi:10.1002/mrm.1910140204
更新日期:1990-05-01 00:00:00
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更新日期:2018-03-01 00:00:00
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更新日期:2017-09-01 00:00:00
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更新日期:1994-11-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2016-10-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:1993-06-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2011-06-01 00:00:00
abstract::Uncertainty regarding the intracellular/extracellular distribution of inorganic phosphate (P(i)) in tumors has raised concerns that pH calculated from the tumor P(i) chemical shift may not accurately represent the intracellular pH (pHin). This issue was addressed in subcutaneously transplanted murine radiation induced...
journal_title:Magnetic resonance in medicine
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更新日期:1996-11-01 00:00:00
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更新日期:2010-01-01 00:00:00
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更新日期:2019-02-01 00:00:00
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更新日期:2020-10-01 00:00:00