ΔR2 (*) gadolinium-diethylenetriaminepentacetic acid relaxivity in venous blood.

Abstract:

:The accuracy of perfusion measurements using dynamic, susceptibility-weighted, contrast-enhanced MRI depends on estimating contrast agent concentration in an artery, i.e., the arterial input function. One of the difficulties associated with obtaining an arterial input function are partial volume effects when both blood and brain parenchyma occupy the same pixel. Previous studies have attempted to correct arterial input functions which suffer from partial volume effects using contrast concentration in venous blood. However, the relationship between relaxation and concentration (C) in venous blood has not been determined in vivo. In this note, a previously employed fitting approach is used to determine venous relaxivity in vivo. In vivo relaxivity is compared with venous relaxivity measured in vitro in bulk blood. The results show that the fitting approach produces relaxivity calibration curves which give excellent agreement with arterial measurements.

journal_name

Magn Reson Med

authors

Patil V,Johnson G

doi

10.1002/mrm.24331

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

1104-8

issue

4

eissn

0740-3194

issn

1522-2594

journal_volume

69

pub_type

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