Abstract:
PURPOSE:Classification of pediatric brain tumors from 1 H-magnetic resonance spectroscopy (MRS) can aid diagnosis and management of brain tumors. However, varied incidence of the different tumor types leads to imbalanced class sizes and introduces difficulties in classifying rare tumor groups. This study assessed different imbalanced multiclass learning techniques and compared the use of complete spectra and quantified metabolite profiles for classification of three main childhood brain tumor types. METHODS:Single-voxel, Short echo time MRS data were collected from 90 patients with pilocytic astrocytoma (n = 42), medulloblastoma (n = 38), or ependymoma (n = 10). Both spectra and metabolite profiles were used to develop the learning algorithms. The borderline synthetic minority oversampling technique and AdaboostM1 were used to correct for the skewed distribution. Classifiers were trained using five different pattern recognition algorithms. RESULTS:Use of imbalanced learning techniques improved the balanced accuracy rate (BAR) of all classification methods (average BAR over all classification methods for spectra: oversampled data = 0.81, original = 0.63, P < 0.001; metabolite concentration: oversampled-data = 0.91, original = 0.75, P < 0.0001). Performance of all classifiers in discriminating ependymomas increased when oversampled data were used compared with original data for both complete spectra (F-measure P < 0.01) and metabolite profile (F-measure P < 0.001). CONCLUSION:Imbalanced learning techniques improve the classification accuracy of childhood brain tumors from MRS where group sizes differ and facilitate the inclusion of rarer tumor types into clinical decision support systems. Magn Reson Med 77:2114-2124, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Zarinabad N,Wilson M,Gill SK,Manias KA,Davies NP,Peet ACdoi
10.1002/mrm.26318subject
Has Abstractpub_date
2017-06-01 00:00:00pages
2114-2124issue
6eissn
0740-3194issn
1522-2594journal_volume
77pub_type
杂志文章abstract:PURPOSE:To validate an automatic algorithm for offline T2* measurements, providing robust, vendor-independent T2*, and uncertainty estimates for iron load quantification in the heart and liver using clinically available imaging sequences. METHODS:A T2* region of interest (ROI)-based algorithm was developed for robustn...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25767
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abstract::Patient-specific radiofrequency shimming in high-field MRI strengthens the need for online, patient-specific specific absorption rate (SAR) monitoring. Numerical simulation is currently most effective for this purpose but may require a patient-specific dielectric model. To investigate whether a generic model may be co...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24378
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abstract:PURPOSE:To develop a strategy for training a physics-guided MRI reconstruction neural network without a database of fully sampled data sets. METHODS:Self-supervised learning via data undersampling (SSDU) for physics-guided deep learning reconstruction partitions available measurements into two disjoint sets, one of wh...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28378
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:The purpose of this project was to construct a physical brain phantom for MRI, mimicking structure and T1 relaxation properties of white matter (WM) and gray matter (GM). METHODS:The phantom design comprised 2 compartments, 1 resembling the WM and 1 resembling the GM. Their T1 relaxation times, as assessed usi...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27464
更新日期:2019-02-01 00:00:00
abstract::Gradient-recalled echo-planar (T2*-weighted) imaging was used to noninvasively monitor regional blood oxygenation state changes in real time during transient episodes of focal ischemia in cat brain. Varying ischemic intervals (12 s to 30 min) were caused by middle cerebral artery occlusion. A rapid signal drop was not...
journal_title:Magnetic resonance in medicine
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abstract:PURPOSE:Endothelial nitric oxide synthase (eNOS) plays a central role in regulating vascular tone, blood flow, and microvascular permeability. Endothelial dysfunction, including eNOS dysfunction, is an early biomarker of vascular disease. This study aimed to show that myocardial T1 mapping during nitric oxide synthase ...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.26870
更新日期:2018-04-01 00:00:00
abstract::Diffusion tensor imaging enables in vivo investigation of tissue cytoarchitecture through parameter contrasts sensitive to water diffusion barriers at the micrometer level. Parameters are derived through an estimation process that is susceptible to noise and artifacts. Estimated parameters (e.g., fractional anisotropy...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24324
更新日期:2013-03-01 00:00:00
abstract::Quantitative cerebral tissue volumes may be useful for an objective assessment of pathological changes in brain. Accurate determination of tissue volumes is complicated, however, by the partial volume averaging (PVA) effect. We have, therefore, developed a new pulse sequence that minimizes the PVA through the use of i...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910390614
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abstract::A technique for reconstructing dynamic undersampled MRI data, termed "x-f choice," was developed and applied to dynamic contrast-enhanced MR angiography (DCE-MRA). Regular undersampling in k-t space (a hybrid of k-space and time) creates aliasing in the conjugate x-f space that must be resolved. When regions in the ob...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.21008
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abstract::A method for the acquisition of localized 2D shift-correlated spectra, based on the combination of the stimulated-echo volume-selection and gradient-enhanced COSY experiments, is described. The sequence can be modified to perform a number of localized experiments including HOHAHA and DQF-COSY. The method is demonstrat...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910320216
更新日期:1994-08-01 00:00:00
abstract::Specialized receiver coils having a small sensitive region can provide an improvement in SNR for MR imaging and spectroscopy, at the expense of limiting the usable field of view. This work presents a technique for designing coil arrays that allows the size and location of the sensitive region to be selected remotely. ...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910170128
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abstract::An implementation is reported of an imaging method to obtain MUltiple Resolutions along Phase-encode and Slice-select dimensions (MURPS), which enables dynamic imaging of focal changes using a graded, multiresolution approach. MURPS allows one to trade spatial resolution in part of the volume for improved temporal res...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1126
更新日期:2001-06-01 00:00:00
abstract::A kinetic analysis of water signal intensity changes measured in human visual cortex by PRESS localized 1H spectroscopy at 500 ms resolution with light-emitting diode (LED) goggle stimulation was used to determine vascular transit times for transitions between rest and activation. Monoexponential curve fitting was use...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910340308
更新日期:1995-09-01 00:00:00
abstract:PURPOSE:This study aims to identify work-related and personal factors associated with workers' exposure to static magnetic fields (SMF) and motion-induced time-varying magnetic fields (TVMF) from MRI scanners. METHODS:Measurements of personal exposure to SMF and TVMF were performed among MRI staff during 439 work shif...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25720
更新日期:2016-05-01 00:00:00
abstract::We describe a versatile NMR probe that is designed for a variety of in vivo spectroscopic studies on small animals in vertical wide-bore magnets. Replaceable brackets enable the coils to be exchanged readily in order to observe 1H, 13C, 31P, and other nuclei, and to carry out double-resonance experiments. Two solenoid...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910060102
更新日期:1988-01-01 00:00:00
abstract::Strong, extensive magnetic fringe fields are a significant problem with magnetic resonance imaging magnets. This is particularly acute with 4-T, whole-body research magnets. To date this problem has been addressed by restricting an extensive zone around the unshielded magnet or by placing external unsaturated iron shi...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910290107
更新日期:1993-01-01 00:00:00
abstract::Each k-space segment in multishot diffusion-weighted MRI is affected by a different spatially varying phase which is caused by unavoidable motions and amplified by the diffusion-encoding gradients. A proper image reconstruction therefore requires phase maps for each segment. Such maps are commonly derived from two-dim...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.22126
更新日期:2009-11-01 00:00:00
abstract::The purpose of this study was to determine the value of a blood-pool contrast media (NC100150, Nycomed Imaging (now Amersham Health) Oslo, Norway) for evaluation of venous thrombosis of the deep veins of the pelvis and lower extremities. Twelve patients were prospectively evaluated with conventional X-ray venography (...
journal_title:Magnetic resonance in medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/mrm.10607
更新日期:2003-11-01 00:00:00
abstract:PURPOSE:It has been shown, theoretically and in vivo, that using the Stejskal-Tanner pulsed-gradient, or linear tensor encoding (LTE), and in tissue exhibiting a "stick-like" diffusion geometry, the direction-averaged diffusion-weighted MRI signal at high b-values ( ...
journal_title:Magnetic resonance in medicine
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更新日期:2020-09-01 00:00:00
abstract:PURPOSE:To model and correct the dephasing effects in the gradient-echo signal for arbitrary RF excitation pulses with large flip angles in the presence of macroscopic field variations. METHODS:The dephasing of the spoiled 2D gradient-echo signal was modeled using a numerical solution of the Bloch equations to calcula...
journal_title:Magnetic resonance in medicine
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abstract::To detect perfusion abnormalities in areas of high magnetic susceptibility in the brain, an arterial spin-labeling MRI technique utilizing flow-sensitive alternating inversion recovery (FAIR) and half-Fourier single shot turbo spin-echo (HASTE) for spin preparation and image acquisition, respectively, was developed. I...
journal_title:Magnetic resonance in medicine
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更新日期:2001-03-01 00:00:00
abstract:PURPOSE:Real-time assessment of ventricular volumes requires high acceleration factors. Residual convolutional neural networks (CNN) have shown potential for removing artifacts caused by data undersampling. In this study, we investigated the ability of CNNs to reconstruct highly accelerated radial real-time data in pat...
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更新日期:2019-02-01 00:00:00
abstract:PURPOSE:Quantitative evaluation of dynamic contrast enhanced MRI (DCE-MRI) allows for estimating perfusion, vessel permeability, and tissue volume fractions by fitting signal intensity curves to pharmacokinetic models. These compart mental models assume rapid equilibration of contrast agent within each voxel. However, ...
journal_title:Magnetic resonance in medicine
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更新日期:2018-07-01 00:00:00
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更新日期:2015-08-01 00:00:00
abstract::A single-shot, two-echo method for the simultaneous detection of multiple-quantum (MQ)-filtered gamma-aminobutyric acid (GABA) and creatine (Cr) was developed and demonstrated in the human brain in vivo at 3 Tesla. The simultaneously measured Cr singlet served as a navigator for the spectral phase of GABA and any freq...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20082
更新日期:2004-06-01 00:00:00
abstract::Multislice MR images obtained using a fast spin-echo (FSE) readout are strongly affected by magnetization transfer (MT) effects, which will cause a decrease in the observed longitudinal relaxation times for tissues with a large bound water component. This is pertinent for FSE-based inversion-recovery (IR) sequences, a...
journal_title:Magnetic resonance in medicine
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更新日期:2007-10-01 00:00:00
abstract::Conventional approaches for MR elastography (MRE) using surface drivers have difficulty achieving sufficient shear wave propagation in the prostate gland due to attenuation. In this study we evaluate the feasibility of generating shear wave propagation in the prostate gland using a transurethral device. A novel transu...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.22038
更新日期:2009-09-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2013-06-01 00:00:00
abstract::Free induction decay signals are analyzed by fitting a model function directly in the time domain. No starting values are needed for linear model parameters, and omission of corrupted data points poses no problems. A significant gain of accuracy is achieved by imposing prior knowledge about the model parameters. ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910060111
更新日期:1988-01-01 00:00:00
abstract:PURPOSE:In this study, an iterative k-t principal component analysis (PCA) algorithm with nonrigid frame-to-frame motion correction is proposed for dynamic contrast-enhanced three-dimensional perfusion imaging. METHODS:An iterative k-t PCA algorithm was implemented with regularization using training data corrected for...
journal_title:Magnetic resonance in medicine
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更新日期:2014-07-01 00:00:00