Time-resolved flow measurement in the isolated rat heart: characterization of left coronary artery stenosis.

Abstract:

:The investigation of flow behavior in coronary arteries is of great importance for an understanding of heart failure and heart regulation mechanisms. The purpose of the present study was to demonstrate that flow velocity can be quantified in the coronary arteries of the isolated rat heart with high-resolution phase contrast MRI. A phase contrast cine-FLASH imaging sequence was used for flow quantification with an in-plane resolution of 70 microm and a slice thickness of 500 microm. With time-resolved measurements, coronary flow over the heart cycle was analyzed. Furthermore, the flow behavior in coronary stenosis was investigated and the degree of stenosis was quantified with MR phase contrast imaging. To achieve the required spatial resolution and a satisfactory signal-to-noise ratio, the experiments were performed at 11.75 T.

journal_name

Magn Reson Med

authors

Köhler S,Hiller KH,Jakob PM,Bauer WR,Haase A

doi

10.1002/mrm.10563

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

449-52

issue

3

eissn

0740-3194

issn

1522-2594

journal_volume

50

pub_type

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