Abstract:
PURPOSE:To examine the detection sensitivity for the rapidly exchanging hydroxyl protons of D-glucose using the recently developed on-resonance variable delay multi-pulse (onVDMP) chemical exchange saturation transfer (CEST) technique. METHODS:The onVDMP method was applied for the detection of water signal changes upon venous D-glucose infusion in mice with 9L glioma xenografts. The effect size of onVDMP MRI during infusion was compared with that of conventional continuous wave (CW) CEST MRI. RESULTS:Both methods highlighted the tumor and the blood vessels on D-glucose infusion. In interleaved studies, the mean signal changes detected by onVDMP were found to be 1.8 times higher than those by CW-CEST, attributed to its high labeling efficiency for fast exchanging protons and the labeling of the OH protons over a larger frequency range. CONCLUSIONS:The onVDMP method is a more sensitive technique for the detection of exogenous CEST agents with fast-exchanging protons compared to CW-CEST MRI.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Xu X,Xu J,Chan KWY,Liu J,Liu H,Li Y,Chen L,Liu G,van Zijl PCMdoi
10.1002/mrm.27364subject
Has Abstractpub_date
2019-01-01 00:00:00pages
47-56issue
1eissn
0740-3194issn
1522-2594journal_volume
81pub_type
杂志文章abstract::Cervical spinal cord spectroscopy has the potential to add metabolic information to spinal cord MRI and improve the clinical evaluation and research investigation of spinal cord diseases, such as multiple sclerosis (MS) and intraspinal tumors. However, in vivo proton MR spectroscopy ((1)H-MRS) of the spinal cord is di...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21113
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:To quantify chemical exchange saturation transfer contrast in upper extremities of participants with lymphedema before and after standardized lymphatic mobilization therapy using correction procedures for B0 and B1 heterogeneity, and T1 relaxation. METHODS:Females with (n = 12) and without (n = 17) breast canc...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28031
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:Quantitative myocardial perfusion mapping has advantages over qualitative assessment, including the ability to detect global flow reduction. However, it is not clinically available and remains a research tool. Building upon the previously described imaging sequence, this study presents algorithm and implementat...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27954
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:To develop and validate a regularization approach of optimizing B1 insensitivity of the quantitative magnetization transfer (qMT) pool-size ratio (F). METHODS:An expression describing the impact of B1 inaccuracies on qMT fitting parameters was derived using a sensitivity analysis. To simultaneously optimize fo...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27337
更新日期:2018-12-01 00:00:00
abstract::A methodology is presented for estimating T(1) using a two-point technique with a standard multislice gradient echo sequence. The method explicitly corrects for the shape of the RF pulse and for spatial variations in transmitted RF field intensity. Including these factors in the calculation of T(1) gives a substantial...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1112
更新日期:2001-05-01 00:00:00
abstract:PURPOSE:To develop and test real-time MR elastography for viscoelastic parameter quantification in skeletal muscle during dynamic exercises. METHODS:In 15 healthy participants, 6 groups of lower-leg muscles (tibialis anterior, tibialis posterior, peroneus, extensor digitorum longus, soleus, gastrocnemius) were investi...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28095
更新日期:2020-07-01 00:00:00
abstract::Golgi impregnation is unique in its ability to display the dendritic trees and axons of large numbers of individual neurons by histology. Here we apply magnetic resonance microscopy to visualize the neuroanatomy of animal models by combining histologic fixation chemistry with paramagnetic contrast agents. Although the...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22322
更新日期:2010-05-01 00:00:00
abstract::Reaching the full potential of magnetic resonance imaging (MRI)-positron emission tomography (PET) dual modality systems requires new methodologies in quantitative image analyses. In this study, methods are proposed to convert an arterial input function (AIF) derived from gadolinium-diethylenetriaminepentaacetic acid ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24318
更新日期:2013-03-01 00:00:00
abstract::The focal underdetermined system solver (FOCUSS) was originally designed to obtain sparse solutions by successively solving quadratic optimization problems. This article adapts FOCUSS for a projection reconstruction MR imaging problem to obtain high resolution reconstructions from angular under-sampled radial k-space ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21202
更新日期:2007-04-01 00:00:00
abstract::Consideration of spatially variable noise fields is becoming increasingly necessary in MRI given recent innovations in artifact identification and statistically driven image processing. Fast imaging methods enable study of difficult anatomical targets and improve image quality but also increase the spatial variability...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22013
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:To develop a fully automated trajectory and gradient waveform design for the non-Cartesian shells acquisition, and to develop a magnetization-prepared (MP) shells acquisition to achieve an efficient three-dimensional acquisition with improved gray-to-white brain matter contrast. METHODS:After reviewing the she...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26863
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:Transverse relaxation time (T2 ) mapping with MRI has a plethora of clinical and research applications. Current T2 mapping techniques are based primarily on spin-echo (SE) relaxometry strategies that rely on the signal magnitude, and often suffer from lengthy acquisition times. In this work, we propose a phase-...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28138
更新日期:2020-08-01 00:00:00
abstract::To understand whether the NO-dependent vasodilator L-arginine was effective upon a chronically hypertensive cerebral capillary endothelium, dynamic susceptibility contrast MRI was used to measure the relative cerebral blood volume (rCBV) changes in nonischemic spontaneously hypertensive rats (SHRs). rCBV was measured ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910390123
更新日期:1998-01-01 00:00:00
abstract::The use of paramagnetic pH-sensitive liposomes was recently suggested as a new approach for monitoring pathologic changes in pH by MRI. Such liposomes must be stable in blood and selectively release the encapsulated paramagnetic agent when exposed to lower pH in the target tissue. In the present study, different lipos...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20009
更新日期:2004-04-01 00:00:00
abstract:PURPOSE:To improve imaging performance for body MRI with a local transmit array at 10.5T, the geometry of a dipole antenna was optimized to achieve lower peak specific absorption rate (SAR) levels and a more uniform transmit profile. METHODS:Electromagnetic simulations on a phantom were used to evaluate the SAR and ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28297
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To demonstrate feasibility of exploiting the spatial distribution of off-resonance surrounding metallic implants for accelerating multispectral imaging techniques. THEORY AND METHODS:Multispectral imaging (MSI) techniques perform time-consuming independent three-dimensional acquisitions with varying radio freq...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25087
更新日期:2014-12-01 00:00:00
abstract::Trifluoroacetate and trifluoroacetamide, when added to a suspension of human red blood cells, give rise to separate 19F NMR signals from the intra- and extracellular species. This phenomenon has recently been exploited for measuring the membrane potential of erythrocytes. However, the separation of the peaks was incor...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910180119
更新日期:1991-03-01 00:00:00
abstract:PURPOSE:To remove nuisance signals (e.g., water and lipid signals) for (1) H MRSI data collected from the brain with limited and/or sparse (k, t)-space coverage. METHODS:A union-of-subspace model is proposed for removing nuisance signals. The model exploits the partial separability of both the nuisance signals and the...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25635
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:To investigate the influence of transcytolemmal water exchange on estimates of tissue microstructural parameters derived from diffusion MRI using conventional PGSE and IMPULSED methods. METHODS:Computer simulations were performed to incorporate a broad range of intracellular water life times τin (50-∞ ms), cel...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26309
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:To improve the imaging quality of vessel walls with an endoesophageal Wireless Amplified NMR Detector (WAND). METHODS:A cylindrically shaped double-frequency resonator has been constructed with a single metal wire that is self-connected by a pair of nonlinear capacitors. The double-frequency resonator can conv...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26562
更新日期:2017-11-01 00:00:00
abstract::Ferumoxytol is an ultrasmall superparamagnetic iron oxide agent marketed for the treatment of anemia. There has been increasing interest in its properties as an MRI contrast agent as well as greater awareness of its adverse event profile. This mini-review summarizes the current state of knowledge of the risks of ferum...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章,评审
doi:10.1002/mrm.26151
更新日期:2016-05-01 00:00:00
abstract::The apparent diffusion coefficient (ADC) in the optic nerve was measured from diffusion-weighted magnetic resonance imaging using an intravoxel incoherent motion (IVIM) sequence. The subjects were seven normal volunteers and eight patients with multiple sclerosis (MS) with a total of four optic nerves with acute neuri...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910380317
更新日期:1997-09-01 00:00:00
abstract::The equal-phase line (EPL) algorithm is proposed as a means of allowing rapid Fourier transform (FT) reconstruction of MR image data acquired on a non-Cartesian grid. The pixels on the image are grouped according to their positions. The pixels in a group have the same phase in the complex exponential function -exp[j2p...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10165
更新日期:2002-06-01 00:00:00
abstract::Choline-containing compounds (CCCs) are elevated in breast cancer, and detected in vivo by the (1)H MRS total choline (tCho) resonance (3.25 ppm) and the (31)P MRS phosphomonoester (PME) resonance (3.8 ppm). Both the tCho and PME resonances decrease early after initiation of successful therapy. The single major compon...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21333
更新日期:2007-08-01 00:00:00
abstract::A novel multiple quantum filtering method is proposed that uses a doubly selective pulse termed Delays Alternating with Nutations for Tailored Excitation (DANTE) for multiple quantum preparation. This method selectively prepares GABA-3 and GABA-4 into a multiple quantum state and suppresses all other resonances at 3.0...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10104
更新日期:2002-03-01 00:00:00
abstract::In this work, a new double quantum filter for glutathione (GSH) editing is introduced, combined with the point-resolved spectroscopy localization sequence (PRESS), and demonstrated in vivo. Compared to the conventional double quantum coherence filter, the new filter has two major advantages. First, it eliminates the n...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20788
更新日期:2006-03-01 00:00:00
abstract::In several applications, MRI is used to monitor the time behavior of the signal in an organ of interest; e.g., signal evolution because of physiological motion, activation, or contrast-agent accumulation. Dynamic applications involve acquiring data in a k-t space, which contains both temporal and spatial information. ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199911)42:5<813::aid-mrm1>
更新日期:1999-11-01 00:00:00
abstract::The assessment of myocardial fibrosis and extracellular volume requires accurate estimation of myocardial T1 s. While image acquisition using the modified Look-Locker inversion recovery technique is clinically feasible for myocardial T1 mapping, respiratory motion can limit its applicability. Moreover, the conventiona...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24385
更新日期:2013-05-01 00:00:00
abstract::Minimally invasive cardiac surgery requires arresting and emptying of the heart, which compromises visualization of the surgical field. In this feasibility study a novel surgical procedure is demonstrated in which real-time MRI is used to guide the placement of a prosthetic aortic valve in the beating heart via direct...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21044
更新日期:2006-11-01 00:00:00
abstract:PURPOSE:To develop a framework for respiratory motion-corrected 3D whole-heart water/fat coronary MR angiography (CMRA) at 3T with reduced and predictable scan time. METHODS:A 3D dual-echo acquisition and respiratory motion-corrected reconstruction framework for water/fat CMRA imaging was developed. The acquisition se...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27732
更新日期:2019-08-01 00:00:00