GlucoCEST imaging with on-resonance variable delay multiple pulse (onVDMP) MRI.

Abstract:

PURPOSE:To examine the detection sensitivity for the rapidly exchanging hydroxyl protons of D-glucose using the recently developed on-resonance variable delay multi-pulse (onVDMP) chemical exchange saturation transfer (CEST) technique. METHODS:The onVDMP method was applied for the detection of water signal changes upon venous D-glucose infusion in mice with 9L glioma xenografts. The effect size of onVDMP MRI during infusion was compared with that of conventional continuous wave (CW) CEST MRI. RESULTS:Both methods highlighted the tumor and the blood vessels on D-glucose infusion. In interleaved studies, the mean signal changes detected by onVDMP were found to be 1.8 times higher than those by CW-CEST, attributed to its high labeling efficiency for fast exchanging protons and the labeling of the OH protons over a larger frequency range. CONCLUSIONS:The onVDMP method is a more sensitive technique for the detection of exogenous CEST agents with fast-exchanging protons compared to CW-CEST MRI.

journal_name

Magn Reson Med

authors

Xu X,Xu J,Chan KWY,Liu J,Liu H,Li Y,Chen L,Liu G,van Zijl PCM

doi

10.1002/mrm.27364

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

47-56

issue

1

eissn

0740-3194

issn

1522-2594

journal_volume

81

pub_type

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