The development of a pH-sensitive contrast agent for NMR 1H imaging.

Abstract:

:Fe(III)meso-tetra(4-sulfonatophenyl)porphine (Fe-TPPS4) has been investigated as a potential pH-sensitive nuclear magnetic resonance (NMR) proton image contrast agent. Relaxation rates (1/T1 and 1/T2) of water protons were measured as a function of pH and concentration of Fe-TPPS4 in phosphate-buffered isotonic saline. Transverse relaxation rates (1/T2) did not change appreciably with pH above 6.0. Longitudinal relaxation rates (1/T1) increased significantly between pH 7.75 and 5.75. This effect was more pronounced with the increasing concentration of Fe-TPPS4 from 0.1 to 1.5 mM and is attributed to a pH-dependent equilibrium between the high-spin (S = 5/2) Fe-TPPS4 monomer at low pH and the antiferromagnetically coupled mu-oxodimer O-(FeTPPS4)2 at high pH. The efficacy of this pH-dependent contrast agent is demonstrated in vitro.

journal_name

Magn Reson Med

authors

Helpern JA,Curtis JC,Hearshen D,Smith MB,Welch KM

doi

10.1002/mrm.1910050313

subject

Has Abstract

pub_date

1987-09-01 00:00:00

pages

302-5

issue

3

eissn

0740-3194

issn

1522-2594

journal_volume

5

pub_type

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