Abstract:
PURPOSE:To investigate the heating induced by (pseudo)-continuous arterial spin labeling ((p)CASL) sequences in vivo at 9.4T and to evaluate the benefit of a dedicated labeling coil. METHODS:Temperature was measured continuously in the brain, neck, and rectum of 9 rats with fiber-optic temperature probes while running pCASL-EPI and CASL-EPI sequences, with labeling B1 amplitudes (B1ave ) of 3, 5, and 7 μT and using a dedicated labeling RF coil or a volume coil. From the temperature time courses, the corresponding specific absorption rate (SAR) was computed. A trade-off between SAR and labeling quality was determined based on measured inversion efficiencies. RESULTS:ASL experiments with standard parameters (B1ave = 5 µT, Tacq = 4 min, labeling with volume coil) lead to a brain temperature increase due to RF of 0.72 ± 0.46 K for pCASL and 0.25 ± 0.17 K for CASL. Using a dedicated labeling coil reduced the RF-induced SAR by a factor of 10 in the brain and a factor of 2 in the neck. Besides SAR due to RF, heat from the coil decoupling circuits produced significant temperature increases. When labeling with a dedicated coil, this mechanism was the dominant source of brain heating. At equivalent RF-SAR, CASL provided slightly superior label efficiency to pCASL and is therefore the preferred sequence when an ASL coil is available. CONCLUSION:B1ave = 4-5 µT provided a good compromise between label efficiency and SAR, both for pCASL and CASL. The sensitivity of animals to heating should be taken into account when optimizing preclinical ASL protocols and may require reducing scan duration or lowering B1ave .
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Hirschler L,Collomb N,Voiron J,Köhler S,Barbier EL,Warnking JMdoi
10.1002/mrm.27931subject
Has Abstractpub_date
2020-01-01 00:00:00pages
254-261issue
1eissn
0740-3194issn
1522-2594journal_volume
83pub_type
杂志文章abstract::Intermolecular double quantum coherences (iDQCs), signals that result from simultaneous transitions of two or more separated spins, are known to produce images that are highly sensitive to subvoxel structure, particularly local anisotropy. Here we demonstrate how iDQCs signal can be used to efficiently detect the anis...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21925
更新日期:2009-04-01 00:00:00
abstract:PURPOSE:Despite the increasing understanding of major depressive disorder (MDD) using neuroimaging techniques, the topological organization of anatomical networks underlying MDD remains unclear. METHODS:The topological organization of brain anatomical networks was explored using complex network approaches. Diffusion t...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25036
更新日期:2014-11-01 00:00:00
abstract::In the recently proposed technique Sweep Imaging with Fourier Transform (SWIFT), frequency-modulated radiofrequency pulses are used in concert with simultaneous acquisition to facilitate MRI of samples with very short transverse relaxation time. In the present work, sweep MRI is reviewed from a reconstruction perspect...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22516
更新日期:2010-12-01 00:00:00
abstract::MRI has become an important tool to noninvasively assess global and regional cardiac function, infarct size, or myocardial blood flow in surgically or genetically modified mouse models of human heart disease. Constraints on scan time due to sensitivity to general anesthesia in hemodynamically compromised mice frequent...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22605
更新日期:2011-01-01 00:00:00
abstract::This review reports data on the general and renal tolerance of the paramagnetic contrast agent Gd-DTPA after intravenous administration. Gd-DTPA was administered usually at a dose level of 0.1-0.2 mmol/kg body wt (range: 0.005-0.25 mmol/kg body wt) in cranial, spinal and body MR indications. In phase I-IIIa studies a ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章,评审
doi:10.1002/mrm.1910220212
更新日期:1991-12-01 00:00:00
abstract::Current implementations of coronary artery magnetic resonance angiography (MRA) suffer from limited coverage of the coronary arterial system. Whole-heart coronary MRA was implemented based on a free-breathing steady-state free-precession (SSFP) technique with magnetization preparation. The technique was compared to a ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10653
更新日期:2003-12-01 00:00:00
abstract::Prepolarized MRI uses pulsed magnetic fields to produce MR images by polarizing the sample at one field strength (approximately 0.5 T) before imaging at a much lower field (approximately 50 mT). Contrast reflecting the T(1) of the sample at an intermediate field strength is achieved by polarizing the sample and then a...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20910
更新日期:2006-06-01 00:00:00
abstract::The differential effects of high temperature on 9L rat gliosarcoma cells cultured in two distinctive forms, namely, anchored monolayer cells and multicellular spheroids, were investigated using 31P nuclear magnetic resonance spectroscopy. The critical temperatures resulting in irreversible changes in cellular energeti...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910190233
更新日期:1991-06-01 00:00:00
abstract::MRI of myocardial perfusion observed with an extracellular contrast agent has proven valuable for the detection of coronary artery disease. During contrast enhancement transient dark rim artifacts are sometimes visible, complicating diagnosis and quantification. In this work a quantification of the frequency offsets c...
journal_title:Magnetic resonance in medicine
pub_type: 临床试验,杂志文章
doi:10.1002/mrm.21723
更新日期:2008-10-01 00:00:00
abstract::TOMROP is a multiple readout single inversion-recovery sequence which may potentially allow the measurement of multi-exponential T1 recoveries in vivo by NMR imaging. It is shown that several important modifications must be made to this sequence to permit T1 to be measured accurately and reliably. With these modificat...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910260109
更新日期:1992-07-01 00:00:00
abstract::Parallel transmission has emerged as an efficient means for implementing multidimensional spatially selective radiofrequency excitation pulses. To date, most theoretical and experimental work on parallel transmission radiofrequency (RF) pulse design is based on the small-tip-angle approximation to the Bloch equation. ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22827
更新日期:2011-09-01 00:00:00
abstract::A new method is presented for the quantitative determination of regional blood volumes in vivo. It is based on rapid quantitative T1 mapping by Snapshot FLASH MRI combined with the injection of an intravascular MR contrast agent. Regional blood volumes in four different tissues of the rat (skeletal muscle, heart, live...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910290521
更新日期:1993-05-01 00:00:00
abstract::We report the synthesis and characterization of polyvinyl alcohol (PVA) embolic particles modified with a clinically approved magnetic resonance (MR) contrast agent. PVA particles are used during transcatheter arterial embolization (TAE) procedures and this minimally invasive technique is a widely employed treatment f...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21518
更新日期:2008-04-01 00:00:00
abstract::A technique using hyperpolarized (HP) 3He to image the small airways of the lung by using moderate flip angles and a short scanning period during early inspiration is demonstrated. Flip angles (alpha) ranging from 10-90 degrees were used in guinea pig experiments with scanning during the entire inspiration period. A s...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910390113
更新日期:1998-01-01 00:00:00
abstract::Parallel imaging based on generalized autocalibrating partially parallel acquisitions is widely used in the clinical routine. To date, no detailed analysis has been presented describing the dependence of the image quality on the reconstruction and acquisition parameters such as the number of autocalibration signal (AC...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22803
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:To investigate whether nonlinear dimensionality reduction improves unsupervised classification of (1) H MRS brain tumor data compared with a linear method. METHODS:In vivo single-voxel (1) H magnetic resonance spectroscopy (55 patients) and (1) H magnetic resonance spectroscopy imaging (MRSI) (29 patients) dat...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25447
更新日期:2015-09-01 00:00:00
abstract::Quantification of cerebral blood flow using QUIPSSII pulsed arterial spin labeling requires that the QUIPSS saturation delay TI1 is shorter than the natural temporal bolus width. Yet the duration of the bolus of tagged spins entering the region of interest varies during vasoactive stimuli such as gaseous challenges or...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24412
更新日期:2013-06-01 00:00:00
abstract::Noninvasive investigation of aldose reductase activities in rat testis was performed using 3-fluoro-3-deoxy-D-glucose (3-FDG) and nuclear magnetic resonance (NMR) spectroscopy/imaging. Quantitative determination of testis aldose reductase activities, expressed as the sorbitol index, showed a value similar to that of b...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910290417
更新日期:1993-04-01 00:00:00
abstract::Signal-to-noise ratio (SNR) is a major challenge to sodium magnetic resonance imaging. Phased array coils have been shown significantly improving SNR in proton imaging over volume coils. This study investigates SNR advantage of a 15-channel array head coil (birdcage volume coil for transmit/receive and 15-channel arra...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24192
更新日期:2012-12-01 00:00:00
abstract::The properties of the image noise for selective averaging of phase-encoding lines have been investigated. For a given acquisition time, selective averaging results in a signal-to-noise ratio penalty compared to averaging all lines equally. In addition, selective averaging yields a non uniform distribution of noise cha...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910190115
更新日期:1991-05-01 00:00:00
abstract::A novel multiple quantum filtering method is proposed that uses a doubly selective pulse termed Delays Alternating with Nutations for Tailored Excitation (DANTE) for multiple quantum preparation. This method selectively prepares GABA-3 and GABA-4 into a multiple quantum state and suppresses all other resonances at 3.0...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10104
更新日期:2002-03-01 00:00:00
abstract::Cerebral metabolite concentrations and water content were measured by means of localized proton magnetic resonance spectroscopy in 50 children, while metabolite peak ratios in short echo time spectra were evaluated in 173 examinations. Normative curves for normal development were established for two cerebral locations...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910300405
更新日期:1993-10-01 00:00:00
abstract::A common type of motion present in clinical magnetic resonance imaging examinations is rotational motion, such as that due to voluntary motion during head examinations. The correction scheme presented in this work offers a method for eliminating the effects of rotations within the imaging plane. Integral to the implem...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910330511
更新日期:1995-05-01 00:00:00
abstract:PURPOSE:For ultrahigh field (UHF) MRI, the expected local specific absorption rate (SAR) distribution is usually calculated by numerical simulations using a limited number of generic body models and adding a safety margin to take into account intersubject variability. Assessment of this variability with a large model d...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27518
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:Diffusion-weighted magnetic resonance imaging suffers from physiological noise, such as artifacts caused by motion or system instabilities. Therefore, there is a need for robust diffusion parameter estimation techniques. In the past, several techniques have been proposed, including RESTORE and iRESTORE (Chang e...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25351
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:Imaging gradients result in the generation of concomitant fields, or Maxwell fields, which are of increasing importance at higher gradient amplitudes. These time-varying fields cause additional phase accumulation, which must be compensated for to avoid image artifacts. In the case of gradient systems employing ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26790
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:Magnetization transfer in white matter (WM) causes biexponential relaxation, but most quantitative T1 measurements fit data assuming monoexponential relaxation. The resulting monoexponential T1 estimate varies based on scan parameters and represents a source of variation between studies, especially at high fiel...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25729
更新日期:2016-06-01 00:00:00
abstract::A radiofrequency (RF) time-domain electron paramagnetic resonance (EPR) instrument operating at 300, 600, and 750 MHz was used to image tumor hypoxia with high spatial and temporal resolution. A high-speed signal-averaging Peripheral Component Interconnect (PCI) board with flexibility in the input signal level and the...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21194
更新日期:2007-04-01 00:00:00
abstract::The rotationally invariant trace/3 apparent diffusion coefficients (ADC) of N-acetyl aspartate (NAA), creatine and phosphocreatine (tCr), and choline (Cho) were determined using a diffusion-weighted stimulated echo acquisition mode sequence at 3 T in three separate human brain regions, namely the subcortical white mat...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20427
更新日期:2005-05-01 00:00:00
abstract:PURPOSE:A systematic study of the short-term and long-term variability of regional alveolar partial pressure of oxygen tension (pA O2 ) measurements using (3) He magnetic resonance imaging was presented. Additionally, the repeatability of the average evaluated pA O2 was compared with that of the standard pulmonary func...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24604
更新日期:2013-12-01 00:00:00