Pharmacological MRI of the choroid and retina: blood flow and BOLD responses during nitroprusside infusion.

Abstract:

:Nitroprusside, a vasodilatory nitric oxide donor, is clinically used during vascular surgery and to lower blood pressure in acute hypertension. This article reports a novel application of blood flow (BF) and blood oxygenation level dependent (BOLD) MRI on an 11.7T scanner to image the rat chorioretinal BF and BOLD changes associated with graded nitroprusside infusion. At low doses (1 or 2 μg/kg/min), nitroprusside increased BF as expected but decreased BOLD signals, showing an intriguing BF-BOLD uncoupling. At high doses (3-5 μg/kg/min), nitroprusside decreased BF and markedly decreased BOLD signals. To our knowledge, this is the first pharmacological MRI application of the retina. This approach has potential to open up new avenues to study the drug-related hemodynamic functions and to evaluate the effects of novel therapeutic interventions on BOLD and BF in the normal and diseased retinas.

journal_name

Magn Reson Med

authors

Shih YY,Li G,Muir ER,De La Garza BH,Kiel JW,Duong TQ

doi

10.1002/mrm.24112

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

1273-8

issue

4

eissn

0740-3194

issn

1522-2594

journal_volume

68

pub_type

杂志文章
  • Intensity correction of phased-array surface coil images.

    abstract::Phased-array coils distribute the high signal-to-noise ratio (SNR) performance of their small component surface coils over the larger area covered by the entire array. The inhomogeneous sensitivity profiles of the component surface coils result in images with very high signal near the phased-array and decreased signal...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910350419

    authors: Murakami JW,Hayes CE,Weinberger E

    更新日期:1996-04-01 00:00:00

  • 16-channel bow tie antenna transceiver array for cardiac MR at 7.0 tesla.

    abstract:PURPOSE:To design, evaluate, and apply a bow tie antenna transceiver radiofrequency (RF) coil array tailored for cardiac MRI at 7.0 Tesla (T). METHODS:The radiofrequency (RF) coil array comprises 16 building blocks each containing a bow tie shaped λ/2-dipole antenna. Numerical simulations were used for transmission fi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25840

    authors: Oezerdem C,Winter L,Graessl A,Paul K,Els A,Weinberger O,Rieger J,Kuehne A,Dieringer M,Hezel F,Voit D,Frahm J,Niendorf T

    更新日期:2016-06-01 00:00:00

  • Transrectal probe for 1H MRI and 31P MR spectroscopy of the prostate gland.

    abstract::A transrectal probe for 1H imaging and 31P MR spectroscopy of the prostate gland is described. The probe is covered with plastic and consists of an insectional portion containing an rf coil and a handle containing a tuning and matching circuit. Using this transrectal probe, 1H MR images and the first 31P MR spectra of...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章,评审

    doi:10.1002/mrm.1910110209

    authors: Narayan P,Vigneron DB,Jajodia P,Anderson CM,Hedgcock MW,Tanagho EA,James TL

    更新日期:1989-08-01 00:00:00

  • Dynamic glucose enhanced (DGE) MRI for combined imaging of blood-brain barrier break down and increased blood volume in brain cancer.

    abstract:PURPOSE:Recently, natural d-glucose was suggested as a potential biodegradable contrast agent. The feasibility of using d-glucose for dynamic perfusion imaging was explored to detect malignant brain tumors based on blood brain barrier breakdown. METHODS:Mice were inoculated orthotopically with human U87-EGFRvIII gliom...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25995

    authors: Xu X,Chan KW,Knutsson L,Artemov D,Xu J,Liu G,Kato Y,Lal B,Laterra J,McMahon MT,van Zijl PC

    更新日期:2015-12-01 00:00:00

  • Electrocardiogram acquisition during MR examinations for patient monitoring and sequence triggering.

    abstract::We have developed a method for measuring the electrocardiogram (ECG) continuously during MR examinations. In contrast to ECG acquisition by wires, our new method is to amplify and convert the ECG into an optical signal directly above the patient's heart. The optical signal is transmitted out of the magnet bore by opti...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910320416

    authors: Felblinger J,Lehmann C,Boesch C

    更新日期:1994-10-01 00:00:00

  • New diffusion phantoms dedicated to the study and validation of high-angular-resolution diffusion imaging (HARDI) models.

    abstract::We present new diffusion phantoms dedicated to the study and validation of high-angular-resolution diffusion imaging (HARDI) models. The phantom design permits the application of imaging parameters that are typically employed in studies of the human brain. The phantoms were made of small-diameter acrylic fibers, chose...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21789

    authors: Poupon C,Rieul B,Kezele I,Perrin M,Poupon F,Mangin JF

    更新日期:2008-12-01 00:00:00

  • A molecular theory of relaxation and magnetization transfer: application to cross-linked BSA, a model for tissue.

    abstract::Homogeneous soft tissue, as regards its magnetic relaxation properties, is well-modeled by solutions of cross-linked protein (see Koenig and Brown, Prog. NMR Spectr. 22, 487 (1991)). Interactions at the solute-solvent interface alter the hydrodynamics of solvent water, and also couple the solute and solvent proton Zee...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910300606

    authors: Koenig SH,Brown RD 3rd

    更新日期:1993-12-01 00:00:00

  • Manganese-enhanced MRI of salivary glands and head and neck tumors in living subjects.

    abstract::Manganese-enhanced MRI has previously been used for visualization of brain architecture and functional mapping of neural pathways. The present work investigated the potential of manganese-enhanced MRI for noninvasive imaging of salivary glands in living subjects. Marked shortening of T(1) was observed in salivary glan...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22452

    authors: Seshadri M,Hoy A

    更新日期:2010-09-01 00:00:00

  • Comparison of fitting methods and b-value sampling strategies for intravoxel incoherent motion in breast cancer.

    abstract:PURPOSE:To compare fitting methods and sampling strategies, including the implementation of an optimized b-value selection for improved estimation of intravoxel incoherent motion (IVIM) parameters in breast cancer. METHODS:Fourteen patients (age, 48.4 ± 14.27 years) with cancerous lesions underwent 3 Tesla breast MRI ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25484

    authors: Cho GY,Moy L,Zhang JL,Baete S,Lattanzi R,Moccaldi M,Babb JS,Kim S,Sodickson DK,Sigmund EE

    更新日期:2015-10-01 00:00:00

  • Magnetic resonance imaging of myocardial kinematics. Technique to detect, localize, and quantify the strain rates of the active human myocardium.

    abstract::A magnetic resonance imaging (MRI) method is presented to detect, localize, and quantify myocardial kinematics by measuring the material rate-of-strain tensor at each pixel in gated NMR images of the heart. The immediate, local effect of muscular activity is self-deformation, and the strain tensor is the basic mathema...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910270107

    authors: Wedeen VJ

    更新日期:1992-09-01 00:00:00

  • Incorporation of Rician noise in the analysis of biexponential transverse relaxation in cartilage using a multiple gradient echo sequence at 3 and 7 Tesla.

    abstract:PURPOSE:Previous work has evaluated the quality of different analytic methods for extracting relaxation times from magnitude imaging data exhibiting Rician noise. However, biexponential analysis of relaxation in tissue, including cartilage, and materials is of increasing interest. We, therefore, analyzed biexponential ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25111

    authors: Bouhrara M,Reiter DA,Celik H,Bonny JM,Lukas V,Fishbein KW,Spencer RG

    更新日期:2015-01-01 00:00:00

  • Modulation of water diffusion during gonadotropin-induced ovulation: NMR microscopy of the ovarian follicle.

    abstract::The preovulatory rat follicle reaches a diameter of 1 mm with no internal blood vessels. Nutrient supply to the enclosed oocyte depends solely on passive diffusion across the follicular wall and the follicular fluid. Spin-echo and stimulated-echo NMR microscopy experiments were applied here for studying modulations in...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910340212

    authors: Tempel C,Schiffenbauer YS,Meir G,Neeman M

    更新日期:1995-08-01 00:00:00

  • Dynamic field map estimation using a spiral-in/spiral-out acquisition.

    abstract::The long readout times of single-shot acquisitions and the high field strengths desired for functional MRI (fMRI) using blood oxygenation level-dependent (BOLD) contrast make functional scans sensitive to magnetic field inhomogeneity. If it is not corrected during image reconstruction, field inhomogeneity can cause ge...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20079

    authors: Sutton BP,Noll DC,Fessler JA

    更新日期:2004-06-01 00:00:00

  • Relative indices of water diffusion anisotropy are equivalent in live and formalin-fixed mouse brains.

    abstract::Formalin fixation of tissue is a common laboratory practice. A direct comparison of diffusion tensor imaging (DTI) parameters from mouse brains before (in vivo) and after (ex vivo) formalin fixation is reported herein. Five diffusion indices were examined in a cohort of seven mice: relative anisotropy (RA), directiona...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10605

    authors: Sun SW,Neil JJ,Song SK

    更新日期:2003-10-01 00:00:00

  • Design of spectral-spatial phase prewinding pulses and their use in small-tip fast recovery steady-state imaging.

    abstract:PURPOSE:Spectrally selective "prewinding" radiofrequency pulses can counteract B0 inhomogeneity in steady-state sequences, but can only prephase a limited range of off-resonance. We propose spectral-spatial small-tip angle prewinding pulses that increase the off-resonance bandwidth that can be successfully prephased by...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26794

    authors: Williams SN,Nielsen JF,Fessler JA,Noll DC

    更新日期:2018-03-01 00:00:00

  • Localized double-quantum filter and correlation spectroscopy experiments.

    abstract::Problems with in vivo proton spectroscopy include strong water and lipid signals, and the very complicated structures of the spectra. Multiple-quantum experiments can be designed to overcome these difficulties. Using a volume selective refocusing technique, one can demonstrate how multiple-quantum experiments can be p...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910060311

    authors: McKinnon GC,Bosiger P

    更新日期:1988-03-01 00:00:00

  • Cerebrospinal fluid pulse wave velocity measurements: In vitro and in vivo evaluation of a novel multiband cine phase-contrast MRI sequence.

    abstract:PURPOSE:Intracranial and intraspinal compliance are parameters of interest in the diagnosis and prediction of treatment outcome in patients with normal pressure hydrocephalus and other forms of communicating hydrocephalus. A noninvasive method to estimate the spinal cerebrospinal fluid (CSF) pulse wave velocity (PWV) a...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28430

    authors: Sonnabend K,Brinker G,Maintz D,Bunck AC,Weiss K

    更新日期:2021-01-01 00:00:00

  • Localized 1H NMR measurements of 2-pyrrolidinone in human brain in vivo.

    abstract::Localized 1H NMR homonuclear J editing spectroscopy was used to measure the concentration of 2-pyrrolidinone (PRDN) in the human occipital lobe of five normal and six epileptic subjects taking vigabatrin. PRDN is a lactam cyclization product of gamma-aminobutyric acid (GABA). From a localized volume of 13.5 cm3 in the...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199905)41:5<889::aid-mrm6>

    authors: Hyder F,Petroff OA,Mattson RH,Rothman DL

    更新日期:1999-05-01 00:00:00

  • Volumetric navigators for real-time motion correction in diffusion tensor imaging.

    abstract::Prospective motion correction methods using an optical system, diffusion-weighted prospective acquisition correction, or a free induction decay navigator have recently been applied to correct for motion in diffusion tensor imaging. These methods have some limitations and drawbacks. This article describes a novel techn...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23314

    authors: Alhamud A,Tisdall MD,Hess AT,Hasan KM,Meintjes EM,van der Kouwe AJ

    更新日期:2012-10-01 00:00:00

  • A z-gradient array for simultaneous multi-slice excitation with a single-band RF pulse.

    abstract:PURPOSE:Multi-slice radiofrequency (RF) pulses have higher specific absorption rates, more peak RF power, and longer pulse durations than single-slice RF pulses. Gradient field design techniques using a z-gradient array are investigated for exciting multiple slices with a single-band RF pulse. THEORY AND METHODS:Two d...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27031

    authors: Ertan K,Taraghinia S,Sadeghi A,Atalar E

    更新日期:2018-07-01 00:00:00

  • Bulk volume susceptibility difference between deoxyhemoglobin and oxyhemoglobin for HbA and HbS: A comparative study.

    abstract:PURPOSE:Sickle cell anemia is a blood disorder that alters the morphology and the oxygen affinity of the red blood cells. Cerebral oxygen extraction fraction measurements using quantitative BOLD contrast have been used for assessing inadequate oxygen delivery and the subsequent risk of ischemic stroke in sickle cell an...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28668

    authors: Eldeniz C,Binkley MM,Fields M,Guilliams K,Ragan DK,Chen Y,Lee JM,Ford AL,An H

    更新日期:2021-01-21 00:00:00

  • Localization errors in MR spectroscopic imaging due to the drift of the main magnetic field and their correction.

    abstract:PURPOSE:To analyze the effect of B0 field drift on multivoxel MR spectroscopic imaging and to propose an approach for its correction. THEORY AND METHODS:It is shown, both theoretically and in a phantom, that for ∼30 min acquisitions a linear B0 drift (∼0.1 ppm/h) will cause localization errors that can reach several v...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24536

    authors: Tal A,Gonen O

    更新日期:2013-10-01 00:00:00

  • Cortical hypoperfusion in the B6.PS2APP mouse model for Alzheimer's disease: comprehensive phenotyping of vascular and tissular parameters by MRI.

    abstract::Function and morphology of the cerebral vasculature were studied in the amyloid (Abeta) plaque-containing double-transgenic (TG) B6.PS2APP Alzheimer's disease (AD) mouse model with MRI at an age range of 10 to 17 months. Perfusion, blood volume, and average vessel geometry were assessed in the brain and compared to ag...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21985

    authors: Weidensteiner C,Metzger F,Bruns A,Bohrmann B,Kuennecke B,von Kienlin M

    更新日期:2009-07-01 00:00:00

  • Is the detection of fucose cancer markers by 2D 1H NMR unequivocal?

    abstract::Fucose is believed to be a marker for cancer that may be detectable by the 2D proton NMR (COSY) of human plasma. However, the COSY technique is time consuming and prone to error. These problems may be alleviated by using the SUPERCOSY pulse sequence; this technique shows that there are many other cross peaks in the re...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910150102

    authors: Phillips PS,Herring FG

    更新日期:1990-07-01 00:00:00

  • Uncovering of intracellular water in cultured cells.

    abstract::The complexity of biologic tissues, with multiple compartments each with its own diffusion and relaxation properties, requires complex formalisms to model water signal in most magnetic resonance imaging or magnetic resonance spectroscopy experiments. In this article, we describe a magnetic susceptibility-induced shift...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20565

    authors: Galons JP,Lope-Piedrafita S,Divijak JL,Corum C,Gillies RJ,Trouard TP

    更新日期:2005-07-01 00:00:00

  • Investigation of human cervical and upper thoracic spinal cord motion: implications for imaging spinal cord structure and function.

    abstract::Spinal cord (SC) motion is thought to be the dominant source of error in current diffusion and spinal functional MRI (fMRI) methods. However, until now, such motion has not been well characterized in three dimensions. While previous studies have predominantly examined motion in the superior/inferior (S/I) direction, t...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21260

    authors: Figley CR,Stroman PW

    更新日期:2007-07-01 00:00:00

  • Proteoglycan-induced changes in T1rho-relaxation of articular cartilage at 4T.

    abstract::Proteoglycan (PG) depletion-induced changes in T1rho (spin-lattice relaxation in rotating frame) relaxation and dispersion in articular cartilage were studied at 4T. Using a spin-lock cluster pre-encoded fast spin echo sequence, T1rho maps of healthy bovine specimens and specimens that were subjected to PG depletion w...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1208

    authors: Akella SV,Regatte RR,Gougoutas AJ,Borthakur A,Shapiro EM,Kneeland JB,Leigh JS,Reddy R

    更新日期:2001-09-01 00:00:00

  • Dynamic changes in water ADC, energy metabolism, extracellular space volume, and tortuosity in neonatal rat brain during global ischemia.

    abstract::To obtain a better understanding of the mechanisms underlying early changes in the brain water apparent diffusion coefficient (ADC) observed in cerebral ischemia, dynamic changes in the ADC of water and in the energy status were measured at postnatal day 8 or 9 in neonatal rat brains after cardiac arrest using 1H MRS/...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910360110

    authors: van der Toorn A,Syková E,Dijkhuizen RM,Vorísek I,Vargová L,Skobisová E,van Lookeren Campagne M,Reese T,Nicolay K

    更新日期:1996-07-01 00:00:00

  • Whole-body continuously moving table fat-water MRI with dynamic B0 shimming at 3 Tesla.

    abstract:PURPOSE:The purpose of this work was to develop a rapid and robust whole-body fat-water MRI (FWMRI) method using a continuously moving table (CMT) with dynamic field corrections at 3 Tesla. METHODS:CMT FWMRI was developed at 3 Tesla with a multiecho golden angle (GA) radial trajectory and dynamic B0 field shimming. Wh...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25848

    authors: Sengupta S,Smith DS,Gifford A,Welch EB

    更新日期:2016-07-01 00:00:00

  • Measurement of myocardial frequency offsets during first pass of a gadolinium-based contrast agent in perfusion studies.

    abstract::MRI of myocardial perfusion observed with an extracellular contrast agent has proven valuable for the detection of coronary artery disease. During contrast enhancement transient dark rim artifacts are sometimes visible, complicating diagnosis and quantification. In this work a quantification of the frequency offsets c...

    journal_title:Magnetic resonance in medicine

    pub_type: 临床试验,杂志文章

    doi:10.1002/mrm.21723

    authors: Ferreira P,Gatehouse P,Bucciarelli-Ducci C,Wage R,Firmin D

    更新日期:2008-10-01 00:00:00