Uncovering of intracellular water in cultured cells.

Abstract:

:The complexity of biologic tissues, with multiple compartments each with its own diffusion and relaxation properties, requires complex formalisms to model water signal in most magnetic resonance imaging or magnetic resonance spectroscopy experiments. In this article, we describe a magnetic susceptibility-induced shift in the resonance frequency of extracellular water by the introduction of a gadolinium contrast agent to medium perfusing a hollow fiber bioreactor. The frequency shift of the extracellular water (+185 Hz at 9.4 T) uncovers the intracellular water and allows direct measurement of motional and relaxation properties of the intracellular space. The proposed method provides a unique tool for understanding the mechanisms underlining diffusion and relaxation in the intracellular space.

journal_name

Magn Reson Med

authors

Galons JP,Lope-Piedrafita S,Divijak JL,Corum C,Gillies RJ,Trouard TP

doi

10.1002/mrm.20565

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

79-86

issue

1

eissn

0740-3194

issn

1522-2594

journal_volume

54

pub_type

杂志文章
  • A computer simulation program for MR imaging: application to RF and static magnetic field imperfections.

    abstract::A computer simulation program capable of demonstrating various artifacts, such as image distortion caused by metallic implants in MR imaging, is presented. The structure of the program allows for the implementation of various imaging situations as long as spins only experience weak interaction, i.e., the Bloch equatio...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910340418

    authors: Olsson MB,Wirestam R,Persson BR

    更新日期:1995-10-01 00:00:00

  • Simultaneous acquisition of image and navigator slices using CAIPIRINHA for 4D MRI.

    abstract:PURPOSE:Respiratory organ motion is still the major challenge of various image-guided treatments in the abdomen. Dynamic organ motion tracking, necessary for the treatment control, can be performed with volumetric time-resolved MRI that sequentially acquires one image and one navigator slice. Here, a novel imaging meth...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25134

    authors: Celicanin Z,Bieri O,Preiswerk F,Cattin P,Scheffler K,Santini F

    更新日期:2015-02-01 00:00:00

  • Rapid T1 mapping of mouse myocardium with saturation recovery Look-Locker method.

    abstract::Dynamic contrast-enhanced MRI using gadolinium or manganese provides unique characterization of myocardium and its pathology. In this study, an electrocardiography (ECG) triggered saturation recovery Look-Locker method was developed and validated for fast cardiac T(1) mapping in small animal models. By sampling the in...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22544

    authors: Li W,Griswold M,Yu X

    更新日期:2010-11-01 00:00:00

  • MRI relaxation fluctuations in acute reperfused hemorrhagic infarction.

    abstract::MRI evaluations of intramyocardial hemorrhage in acute infarction have relied on T(2) and T(2)(*) shortening only. We propose a more comprehensive evaluation of hemorrhagic infarction based on the concept that fluctuations in T(2) and T(1) relaxation in acute reperfused infarction will reflect transient edema and hemo...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21079

    authors: Foltz WD,Yang Y,Graham JJ,Detsky JS,Wright GA,Dick AJ

    更新日期:2006-12-01 00:00:00

  • Reconstruction by calibration over tensors for multi-coil multi-acquisition balanced SSFP imaging.

    abstract:PURPOSE:To develop a rapid imaging framework for balanced steady-state free precession (bSSFP) that jointly reconstructs undersampled data (by a factor of R) across multiple coils (D) and multiple acquisitions (N). To devise a multi-acquisition coil compression technique for improved computational efficiency. METHODS:...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26902

    authors: Biyik E,Ilicak E,Çukur T

    更新日期:2018-05-01 00:00:00

  • Optimized 3D ultrashort echo time pulmonary MRI.

    abstract:PURPOSE:To optimize 3D radial ultrashort echo time MRI for high resolution whole-lung imaging. METHODS:3D radial ultrashort echo time was implemented on a 3T scanner to investigate the effects of: (1) limited field-of-view excitation, (2) variable density readouts, and (3) radial oversampling. Improvements in noise pe...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24570

    authors: Johnson KM,Fain SB,Schiebler ML,Nagle S

    更新日期:2013-11-01 00:00:00

  • Cerebrospinal fluid pulse wave velocity measurements: In vitro and in vivo evaluation of a novel multiband cine phase-contrast MRI sequence.

    abstract:PURPOSE:Intracranial and intraspinal compliance are parameters of interest in the diagnosis and prediction of treatment outcome in patients with normal pressure hydrocephalus and other forms of communicating hydrocephalus. A noninvasive method to estimate the spinal cerebrospinal fluid (CSF) pulse wave velocity (PWV) a...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28430

    authors: Sonnabend K,Brinker G,Maintz D,Bunck AC,Weiss K

    更新日期:2021-01-01 00:00:00

  • Quantitative MRI assessment of leukoencephalopathy.

    abstract::Quantitative MRI assessment of leukoencephalopathy is difficult because the MRI properties of leukoencephalopathy significantly overlap those of normal tissue. This report describes the use of an automated procedure for longitudinal measurement of tissue volume and relaxation times to quantify leukoencephalopathy. Ima...

    journal_title:Magnetic resonance in medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/mrm.10124

    authors: Reddick WE,Glass JO,Langston JW,Helton KJ

    更新日期:2002-05-01 00:00:00

  • Quantifying endogenous glucose production and contributing source fluxes from a single 2H NMR spectrum.

    abstract::Endogenous glucose production (EGP), gluconeogenic and glycogenolytic fluxes by analysis of a single (2)H-NMR spectrum is demonstrated with 6-hr and 24-hr fasted rats. Animals were administered [1-(2)H, 1-(13)C]glucose, a novel tracer of glucose turnover, and (2)H(2)O. Plasma glucose enrichment from both tracers was q...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22062

    authors: Nunes PM,Jones JG

    更新日期:2009-09-01 00:00:00

  • Variable echo time imaging: signal characteristics of 1-M gadobutrol contrast agent at 1.5 and 3T.

    abstract::Gadobutrol (Gd-Bt; Gadovist(R), Schering AG) is a 1-M Gadolinium (Gd)-based contrast agent. Its higher Gd concentration allows for reduction of injection volumes in first pass contrast-enhanced MR angiography (CE-MRA) and should increase bolus sharpness and image quality. However, ambivalent results were reported. In ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21345

    authors: Stalder AF,Elverfeldt DV,Paul D,Hennig J,Markl M

    更新日期:2008-01-01 00:00:00

  • Safety and technique of ferumoxytol administration for MRI.

    abstract::Ferumoxytol is an ultrasmall superparamagnetic iron oxide agent marketed for the treatment of anemia. There has been increasing interest in its properties as an MRI contrast agent as well as greater awareness of its adverse event profile. This mini-review summarizes the current state of knowledge of the risks of ferum...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章,评审

    doi:10.1002/mrm.26151

    authors: Vasanawala SS,Nguyen KL,Hope MD,Bridges MD,Hope TA,Reeder SB,Bashir MR

    更新日期:2016-05-01 00:00:00

  • Pulmonary perfusion: qualitative assessment with dynamic contrast-enhanced MRI using ultra-short TE and inversion recovery turbo FLASH.

    abstract::The accurate assessment of pulmonary perfusion is especially important in the evaluation of patients with suspected pulmonary embolism, a common and potentially lethal disorder that can be treated by aggressive anticoagulation. In this study, we demonstrate for the first time the use of MR to image pulmonary perfusion...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910360402

    authors: Hatabu H,Gaa J,Kim D,Li W,Prasad PV,Edelman RR

    更新日期:1996-10-01 00:00:00

  • B0 concomitant field compensation for MRI systems employing asymmetric transverse gradient coils.

    abstract:PURPOSE:Imaging gradients result in the generation of concomitant fields, or Maxwell fields, which are of increasing importance at higher gradient amplitudes. These time-varying fields cause additional phase accumulation, which must be compensated for to avoid image artifacts. In the case of gradient systems employing ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26790

    authors: Weavers PT,Tao S,Trzasko JD,Frigo LM,Shu Y,Frick MA,Lee SK,Foo TK,Bernstein MA

    更新日期:2018-03-01 00:00:00

  • The fractionated dipole antenna: A new antenna for body imaging at 7 Tesla.

    abstract:PURPOSE:Dipole antennas in ultrahigh field MRI have demonstrated advantages over more conventional designs. In this study, the fractionated dipole antenna is presented: a dipole where the legs are split into segments that are interconnected by capacitors or inductors. METHODS:A parameter study has been performed on di...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25596

    authors: Raaijmakers AJ,Italiaander M,Voogt IJ,Luijten PR,Hoogduin JM,Klomp DW,van den Berg CA

    更新日期:2016-03-01 00:00:00

  • Echo time-dependent quantitative susceptibility mapping contains information on tissue properties.

    abstract:PURPOSE:Magnetic susceptibility is a physical property of matter that varies depending on chemical composition and abundance of different molecular species. Interest is growing in mapping of magnetic susceptibility in the human brain using magnetic resonance imaging techniques, but the influences affecting the mapped v...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26281

    authors: Sood S,Urriola J,Reutens D,O'Brien K,Bollmann S,Barth M,Vegh V

    更新日期:2017-05-01 00:00:00

  • Myocardial T2* mapping free of distortion using susceptibility-weighted fast spin-echo imaging: a feasibility study at 1.5 T and 3.0 T.

    abstract::This study demonstrates the feasibility of applying free-breathing, cardiac-gated, susceptibility-weighted fast spin-echo imaging together with black blood preparation and navigator-gated respiratory motion compensation for anatomically accurate T2* mapping of the heart. First, T2* maps are presented for oil phantoms ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22054

    authors: Heinrichs U,Utting JF,Frauenrath T,Hezel F,Krombach GA,Hodenius MA,Kozerke S,Niendorf T

    更新日期:2009-09-01 00:00:00

  • "PINOT": time-resolved parallel magnetic resonance imaging with a reduced dynamic field of view.

    abstract::This article introduces a novel method named "Parallel Imaging and Noquist in Tandem" (PINOT) for accelerated image acquisition of cine cardiac magnetic resonance imaging. This method combines two prior information formalisms, the SPACE-RIP implementation of parallel imaging and the Noquist method for reduced-data ima...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22696

    authors: Hamilton LH,Fabregat JA,Moratal D,Ramamurthy S,Lerakis S,Parks WJ,Sallee D 3rd,Brummer ME

    更新日期:2011-04-01 00:00:00

  • Polymetallic macromolecules are potential contrast agents of improved efficiency.

    abstract::The commercial synthetic homopolypeptide polyaspartate (average MW = 30,000, approximately 220 monomers) in solution quantitatively binds up to 40 mol Gd3+ ions per mole of polyaspartate. The water proton relaxivity of the solutions is far higher than that of clinically used or commonly investigated gadolinium(III) co...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910310109

    authors: Cavagna F,Luchinat C,Scozzafava A,Xia Z

    更新日期:1994-01-01 00:00:00

  • Ramped hybrid encoding for improved ultrashort echo time imaging.

    abstract:PURPOSE:We propose a new acquisition to minimize the per-excitation encoding duration and improve the imaging capability for short T2 * species. METHODS:In the proposed ramped hybrid encoding (RHE) technique, gradients are applied before the radiofrequency (RF) pulse as in pointwise encoding time reduction with radial...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25977

    authors: Jang H,Wiens CN,McMillan AB

    更新日期:2016-09-01 00:00:00

  • Improved activation maps via the elimination of motion effects through time-domain mixing of data in conventional gradient echo functional MRI.

    abstract::To date, most functional imaging centers have relied on ultrafast imaging approaches such as echo-planar imaging (EPI) techniques for acquiring functional brain activation data. These methods require specialized hardware and are not yet installed widely on clinical MR imagers, thus limiting the application of function...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910380417

    authors: Constable RT

    更新日期:1997-10-01 00:00:00

  • Extended graphical model for analysis of dynamic contrast-enhanced MRI.

    abstract::Kinetic analysis with mathematical models has become increasingly important to quantify physiological parameters in computed tomography (CT), positron emission tomography (PET), and dynamic contrast-enhanced MRI (DCE-MRI). The modified Kety/Tofts model and the graphical (Patlak) model have been widely applied to DCE-M...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22819

    authors: Chen H,Li F,Zhao X,Yuan C,Rutt B,Kerwin WS

    更新日期:2011-09-01 00:00:00

  • In vivo whole-blood T2 versus HbO2 calibration by modulating blood oxygenation level in the femoral vein through intermittent cuff occlusion.

    abstract:PURPOSE:To investigate the feasibility of estimating calibration constants (K and T2o ) in vivo for converting whole-blood T2 to blood hemoglobin oxygen saturation (HbO2 ) according to the Luz-Meiboom model, 1/T2=1/T2o+K(1-HbO2)2, where K and T2o are relaxivity and transverse relaxation time of fully saturated blood, r...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26885

    authors: Langham MC,Rodríguez-Soto AE,Schwartz N,Wehrli FW

    更新日期:2018-04-01 00:00:00

  • In vivo 13C magnetic resonance spectroscopy of human brain on a clinical 3 T scanner using [2-13C]glucose infusion and low-power stochastic decoupling.

    abstract::This study presents the detection of [2-(13)C]glucose metabolism in the carboxylic/amide region in the human brain, and demonstrates that the cerebral metabolism of [2-(13)C]glucose can be studied in human subjects in the presence of severe hardware constraints of widely available 3 T clinical scanners and with low-po...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22044

    authors: Li S,Zhang Y,Wang S,Yang J,Ferraris Araneta M,Farris A,Johnson C,Fox S,Innis R,Shen J

    更新日期:2009-09-01 00:00:00

  • Safety of gadolinium-DTPA: extended clinical experience.

    abstract::This review reports data on the general and renal tolerance of the paramagnetic contrast agent Gd-DTPA after intravenous administration. Gd-DTPA was administered usually at a dose level of 0.1-0.2 mmol/kg body wt (range: 0.005-0.25 mmol/kg body wt) in cranial, spinal and body MR indications. In phase I-IIIa studies a ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章,评审

    doi:10.1002/mrm.1910220212

    authors: Niendorf HP,Haustein J,Cornelius I,Alhassan A,Clauss W

    更新日期:1991-12-01 00:00:00

  • Rapid whole-brain gray matter imaging using single-slab three-dimensional dual-echo fast spin echo: A feasibility study.

    abstract:PURPOSE:To achieve rapid, high resolution whole-brain gray matter (GM) imaging by developing a novel, single-slab three-dimensional dual-echo fast-spin-echo pulse sequence and GM-selective reconstruction. METHODS:Unlike conventional GM imaging that uses time-consuming double-inversion-recovery preparation, the propose...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26910

    authors: Lee H,Kim EY,Sohn CH,Park J

    更新日期:2017-11-01 00:00:00

  • Fast gated EPR imaging of the beating heart: spatiotemporally resolved 3D imaging of free-radical distribution during the cardiac cycle.

    abstract::In vivo or ex vivo electron paramagnetic resonance imaging (EPRI) is a powerful technique for determining the spatial distribution of free radicals and other paramagnetic species in living organs and tissues. However, applications of EPRI have been limited by long projection acquisition times and the consequent fact t...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24250

    authors: Chen Z,Reyes LA,Johnson DH,Velayutham M,Yang C,Samouilov A,Zweier JL

    更新日期:2013-02-01 00:00:00

  • Optimization of survey protocols for MRI.

    abstract::A method for evaluating the sensitivity of MRI protocols to changes in an arbitrary number of tissue parameters over a broad range of parameter values is presented. This analysis is useful for choosing an optimal basis set of images for either a "survey" protocol or tissue segmentation algorithms. A survey protocol is...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910130202

    authors: McVeigh ER,Henkelman RM,Bronskill MJ

    更新日期:1990-02-01 00:00:00

  • Selection and evaluation of optimal two-dimensional CAIPIRINHA kernels applied to time-resolved three-dimensional CE-MRA.

    abstract:PURPOSE:To develop and validate a method for choosing the optimal two-dimensional CAIPIRINHA kernel for subtraction contrast-enhanced MR angiography (CE-MRA) and estimate the degree of image quality improvement versus that of some reference acceleration parameter set at R ≥ 8. METHODS:A metric based on patient-specifi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25366

    authors: Weavers PT,Borisch EA,Riederer SJ

    更新日期:2015-06-01 00:00:00

  • Specific absorption rate intersubject variability in 7T parallel transmit MRI of the head.

    abstract::Patient-specific radiofrequency shimming in high-field MRI strengthens the need for online, patient-specific specific absorption rate (SAR) monitoring. Numerical simulation is currently most effective for this purpose but may require a patient-specific dielectric model. To investigate whether a generic model may be co...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24378

    authors: de Greef M,Ipek O,Raaijmakers AJ,Crezee J,van den Berg CA

    更新日期:2013-05-01 00:00:00

  • SSFP signal with finite RF pulses.

    abstract::The theoretical description of steady state free precession (SSFP) sequences is generally well accepted and unquestioned, although it is based on instantaneously acting radiofrequency (RF) pulses. In practice, however, all excitation processes are finite, thereby questioning the overall validity of the common SSFP sig...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22116

    authors: Bieri O,Scheffler K

    更新日期:2009-11-01 00:00:00