Optimization of survey protocols for MRI.

Abstract:

:A method for evaluating the sensitivity of MRI protocols to changes in an arbitrary number of tissue parameters over a broad range of parameter values is presented. This analysis is useful for choosing an optimal basis set of images for either a "survey" protocol or tissue segmentation algorithms. A survey protocol is required when searching for a lesion of unknown type or location. Segmentation requires unique signal signatures for tissues that may cover a broad range of tissue parameter values. Data acquisition is modeled as a mapping of a domain of tissue parameter values into a signal manifold in a signal strength space defined by the MRI protocol. The efficacy of the protocol is evaluated by investigating the characteristics of the signal manifold. A figure of merit which maximizes the probability of discriminating each point in the domain of tissue parameters from all others is developed.

journal_name

Magn Reson Med

authors

McVeigh ER,Henkelman RM,Bronskill MJ

doi

10.1002/mrm.1910130202

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

177-91

issue

2

eissn

0740-3194

issn

1522-2594

journal_volume

13

pub_type

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