Abstract:
:The ability to directly detect neuronal magnetic fields by MRI would help investigators achieve the "holy grail" of neuroimaging, namely both high spatial and temporal resolution. Both positive and negative findings have been reported in the literature, with no clear consensus as to the feasibility of direct detection. The aim of this study was to replicate one of the most promising published in vivo results. A second aim was to investigate the use of steady-state visual evoked potentials (ssVEPs), which give a large evoked response and offer a well-controlled approach because the frequency of the neuronal response can be dictated by the experimenter. For both studies we used a general linear model (GLM) that included regressors for both the expected blood oxygen level-dependent (BOLD) signal and the magnetic source (MS) signal. The results showed no activity that could be attributed to the neuromagnetic signals in either study, and no frequency component corresponding to the frequency of the ssVEPs. This study demonstrates that for the particular stimuli and hardware used, the sensitivity of the magnitude MRI signal to detect evoked neuronal currents is too low to be of practical use.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Parkes LM,de Lange FP,Fries P,Toni I,Norris DGdoi
10.1002/mrm.21129subject
Has Abstractpub_date
2007-02-01 00:00:00pages
411-6issue
2eissn
0740-3194issn
1522-2594journal_volume
57pub_type
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journal_title:Magnetic resonance in medicine
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更新日期:2004-03-01 00:00:00
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