Measurement of myocardial frequency offsets during first pass of a gadolinium-based contrast agent in perfusion studies.

Abstract:

:MRI of myocardial perfusion observed with an extracellular contrast agent has proven valuable for the detection of coronary artery disease. During contrast enhancement transient dark rim artifacts are sometimes visible, complicating diagnosis and quantification. In this work a quantification of the frequency offsets caused solely by the first pass of Gd-DTPA in a typical perfusion setup was made in vivo and compared with both phantom work and numerical simulations data. The results show that numerically simulated and phantom data agree well with in vivo frequency offsets. During the first pass main field distortion occurs mainly in the subendocardium, and the same pattern is always observed: positive for posterior/anterior regions, negative for septal/lateral regions (from -69 to 85 Hz). The larger myocardial frequency offsets were measured for patients with greater angles between the long axis of the heart and the direction of the main field. From these results it would appear that the frequency offsets are too weak to cause dark rim artifacts due simply to intravoxel dephasing in a typical perfusion sequence. However, when added to other sources of off-resonance it can cause dark rims in particular regions of the myocardium wall in balanced-SSFP sequences.

journal_name

Magn Reson Med

authors

Ferreira P,Gatehouse P,Bucciarelli-Ducci C,Wage R,Firmin D

doi

10.1002/mrm.21723

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

860-70

issue

4

eissn

0740-3194

issn

1522-2594

journal_volume

60

pub_type

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