Abstract:
:Proton T2 relaxation and its biexponential components have been determined in rabbit skeletal muscle in the presence and absence of GdDTPA. The effect of GdDTPA, which distributes only in the extracellular space, was greatest in the longer-relaxing T2 component (T22). A 27% reduction in T22 was measured for slow-twitch (red) muscle and 17% for fast-twitch (white) muscle, consistent with the larger extracellular space of the former. Magnetic resonance images demonstrated apparent contrast between red and white rabbit muscles. This contrast was instantaneously enhanced by administration of GdDTPA and returned to near normal levels after approximately 30 min. These functional changes in tissue contrast are consistent with differences in blood perfusion and biological water compartmentation between fast- and slow-twitch skeletal muscles.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Adzamli IK,Jolesz FA,Bleier AR,Mulkern RV,Sandor Tdoi
10.1002/mrm.1910110205subject
Has Abstractpub_date
1989-08-01 00:00:00pages
172-81issue
2eissn
0740-3194issn
1522-2594journal_volume
11pub_type
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