The effect of gadolinium DTPA on tissue water compartments in slow- and fast-twitch rabbit muscles.

Abstract:

:Proton T2 relaxation and its biexponential components have been determined in rabbit skeletal muscle in the presence and absence of GdDTPA. The effect of GdDTPA, which distributes only in the extracellular space, was greatest in the longer-relaxing T2 component (T22). A 27% reduction in T22 was measured for slow-twitch (red) muscle and 17% for fast-twitch (white) muscle, consistent with the larger extracellular space of the former. Magnetic resonance images demonstrated apparent contrast between red and white rabbit muscles. This contrast was instantaneously enhanced by administration of GdDTPA and returned to near normal levels after approximately 30 min. These functional changes in tissue contrast are consistent with differences in blood perfusion and biological water compartmentation between fast- and slow-twitch skeletal muscles.

journal_name

Magn Reson Med

authors

Adzamli IK,Jolesz FA,Bleier AR,Mulkern RV,Sandor T

doi

10.1002/mrm.1910110205

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

172-81

issue

2

eissn

0740-3194

issn

1522-2594

journal_volume

11

pub_type

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