Changes in T2*-weighted images during hyperoxia differentiate tumors from normal tissue.

Abstract:

:Experiments were performed to determine whether changes in T2*-weighted MR images during and after hyperoxia differentiate tumors from normal tissue. Mammary adenocarcinomas implanted in the right hind limbs of rats were studied. Gradient echo images were obtained at 2 Tesla with an evolution time of 20 ms and a recycle time of 1 s. Breathing gas was either air or 100% O2. Significant increases in image intensity were observed in tumor centers and rims during hyperoxia while much smaller changes were detected in the surrounding muscle. The relaxation rate (1/T2*) in tumors decreased during hyperoxia by an average of 2.5 +/- 1.0 s-1, while in muscle the average change was an increase of 0.6 +/- 2.1 s-1. The largest decreases in relaxation rate were detected in non-necrotic tumor regions with relatively low density of blood vessels. Immediately following hyperoxia significant decreases in intensity were detected in tumors while much smaller decreases were detected in the surrounding muscle.

journal_name

Magn Reson Med

authors

Kuperman VYu,River JN,Lewis MZ,Lubich LM,Karczmar GS

doi

10.1002/mrm.1910330306

subject

Has Abstract

pub_date

1995-03-01 00:00:00

pages

318-25

issue

3

eissn

0740-3194

issn

1522-2594

journal_volume

33

pub_type

杂志文章
  • Local planar gradients with order-of-magnitude strength and speed advantage.

    abstract::A three-axis uniplanar gradient coil was designed and built to provide order-of-magnitude increases in gradient strength of up to 500 mT/m on the x- and y-axes, and 1000 mT/m for the z-axis at 640 A input over a limited FOV ( approximately 16 cm) for superficial regions, compared to conventional gradient coils, with s...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21263

    authors: Aksel B,Marinelli L,Collick BD,Von Morze C,Bottomley PA,Hardy CJ

    更新日期:2007-07-01 00:00:00

  • CEST MRI quantification procedures for breast cancer treatment-related lymphedema therapy evaluation.

    abstract:PURPOSE:To quantify chemical exchange saturation transfer contrast in upper extremities of participants with lymphedema before and after standardized lymphatic mobilization therapy using correction procedures for B0 and B1 heterogeneity, and T1 relaxation. METHODS:Females with (n = 12) and without (n = 17) breast canc...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28031

    authors: Crescenzi R,Donahue PMC,Mahany H,Lants SK,Donahue MJ

    更新日期:2020-05-01 00:00:00

  • Imaging of the active B1 field in vivo.

    abstract::The authors describe a method for accurate in vivo multislice imaging of the active component of the B1 field which is based on a previously proposed method, which uses the signal intensity ratio of two images measured with different excitation angles, and a repetition time TR 5 > or = 5 T1. The new method essentially...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910350217

    authors: Stollberger R,Wach P

    更新日期:1996-02-01 00:00:00

  • Accurate multislice gradient echo T(1) measurement in the presence of non-ideal RF pulse shape and RF field nonuniformity.

    abstract::A methodology is presented for estimating T(1) using a two-point technique with a standard multislice gradient echo sequence. The method explicitly corrects for the shape of the RF pulse and for spatial variations in transmitted RF field intensity. Including these factors in the calculation of T(1) gives a substantial...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1112

    authors: Parker GJ,Barker GJ,Tofts PS

    更新日期:2001-05-01 00:00:00

  • Design of adiabatic selective pulses using optimal control theory.

    abstract::Optimal control theory has been applied in the past for the design of RF pulses for selective excitation. This was the outcome of having established the controllability of the MR spin system for the selective excitation problem. "Minimum distance" was the main formulation used for the solution. Because of their robust...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910360311

    authors: Rosenfeld D,Zur Y

    更新日期:1996-09-01 00:00:00

  • Parallel reconstruction in accelerated multivoxel MR spectroscopy.

    abstract:PURPOSE:To develop the simultaneous acquisition of multiple voxels in localized MR spectroscopy (MRS) using sensitivity encoding, allowing reduced total scan time compared to conventional sequential single voxel (SV) acquisition methods. METHODS:Dual volume localization was used to simultaneously excite voxels in both...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25718

    authors: Boer VO,Klomp DW,Laterra J,Barker PB

    更新日期:2015-09-01 00:00:00

  • Manganese-enhanced magnetic resonance imaging for in vivo assessment of damage and functional improvement following spinal cord injury in mice.

    abstract::In past decades, much effort has been invested in developing therapies for spinal injuries. Lack of standardization of clinical read-out measures, however, makes direct comparison of experimental therapies difficult. Damage and therapeutic effects in vivo are routinely evaluated using rather subjective behavioral test...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20888

    authors: Stieltjes B,Klussmann S,Bock M,Umathum R,Mangalathu J,Letellier E,Rittgen W,Edler L,Krammer PH,Kauczor HU,Martin-Villalba A,Essig M

    更新日期:2006-05-01 00:00:00

  • Dynamic imaging of perfusion in human skeletal muscle during exercise with arterial spin labeling.

    abstract::MR images acquired by using an arterial spin-labeling technique showed spatial and temporal variations of perfusion in the skeletal muscle of exercising humans. Perfusion measurements made during plantar flexion exercise in normal volunteers were consistent with those obtained by traditional techniques reported in the...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199908)42:2<258::aid-mrm7>

    authors: Frank LR,Wong EC,Haseler LJ,Buxton RB

    更新日期:1999-08-01 00:00:00

  • Functional imaging with FENSI: flow-enhanced signal intensity.

    abstract::Flow measurement methods for functional MRI (fMRI) are desirable as they are more closely tied to neuronal activity than the commonly used blood oxygenation techniques. In this work we introduce a flow-based functional imaging method. The method, called flow enhancement of signal intensity (FENSI), is an extension of ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21325

    authors: Sutton BP,Ouyang C,Ching BL,Ciobanu L

    更新日期:2007-08-01 00:00:00

  • Single acquisition electrical property mapping based on relative coil sensitivities: A proof-of-concept demonstration.

    abstract:PURPOSE:All methods presented to date to map both conductivity and permittivity rely on multiple acquisitions to compute quantitatively the magnitude of radiofrequency transmit fields, B1+. In this work, we propose a method to compute both conductivity and permittivity based solely on relative receive coil sensitivitie...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25399

    authors: Marques JP,Sodickson DK,Ipek O,Collins CM,Gruetter R

    更新日期:2015-07-01 00:00:00

  • Proton MRI as a noninvasive tool to assess elastase-induced lung damage in spontaneously breathing rats.

    abstract::Elastase-induced changes in lung morphology and function were detected in spontaneously breathing rats using conventional proton MRI at 4.7 T. A single dose of porcine pancreatic elastase (75 U/100 g body weight) or vehicle (saline) was administered intratracheally (i.t.) to male Brown Norway (BN) rats. MRI fluid sign...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21051

    authors: Quintana HK,Cannet C,Zurbruegg S,Blé FX,Fozard JR,Page CP,Beckmann N

    更新日期:2006-12-01 00:00:00

  • Selective excitation of two-dimensional arbitrarily shaped voxels with parallel excitation in spectroscopy.

    abstract::Parallel excitation is being studied intensively for applications in MR imaging and in particular for selecting arbitrary shapes as regions of interest. In this work, parallel excitation was applied to arbitrarily shaped voxel selection in spectroscopy and investigated for different excitation k-space trajectories (ra...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23018

    authors: Snyder J,Haas M,Hennig J,Zaitsev M

    更新日期:2012-02-01 00:00:00

  • T2 accuracy on a whole-body imager.

    abstract::MR oximetry requires a T2 measurement that is accurate within 5% in vivo. Simple methods are susceptible to signal loss and tend to underestimate T2. Current methods utilize RF pulses or RF cycling patterns that prevent signal loss at each data acquisition. However, using these methods with imperfect pulses, T2 tends ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910380512

    authors: Foltz WD,Stainsby JA,Wright GA

    更新日期:1997-11-01 00:00:00

  • Value of a blood pool contrast agent in MR venography of the lower extremities and pelvis: preliminary results in 12 patients.

    abstract::The purpose of this study was to determine the value of a blood-pool contrast media (NC100150, Nycomed Imaging (now Amersham Health) Oslo, Norway) for evaluation of venous thrombosis of the deep veins of the pelvis and lower extremities. Twelve patients were prospectively evaluated with conventional X-ray venography (...

    journal_title:Magnetic resonance in medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/mrm.10607

    authors: Aschauer M,Deutschmann HA,Stollberger R,Hausegger KA,Obernosterer A,Schöllnast H,Ebner F

    更新日期:2003-11-01 00:00:00

  • Exploring the limits of RF shimming for high-field MRI of the human head.

    abstract::Several methods have been proposed for overcoming the effects of radiofrequency (RF) magnetic field inhomogeneity in high-field MRI. Some of these methods rely at least in part on the ability to independently control magnitude and phase of different drives in either one multielement RF coil or in different RF coils in...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21013

    authors: Mao W,Smith MB,Collins CM

    更新日期:2006-10-01 00:00:00

  • Functional magnetic resonance imaging in real time (FIRE): sliding-window correlation analysis and reference-vector optimization.

    abstract::New algorithms for correlation analysis are presented that allow the mapping of brain activity from functional MRI (fMRI) data in real time during the ongoing scan. They combine the computation of the correlation coefficients between measured fMRI time-series data and a reference vector with "detrending", a technique ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(200002)43:2<259::aid-mrm13

    authors: Gembris D,Taylor JG,Schor S,Frings W,Suter D,Posse S

    更新日期:2000-02-01 00:00:00

  • Macromolecule and water magnetization exchange modeling in articular cartilage.

    abstract::Magnetization exchange effects between the matrix macromolecules (e. g., collagen and proteoglycan) and water were examined in normal, deuterated, and proteoglycan-depleted articular cartilage. Relaxation results (T(2), T(1rho), and T(1)) suggested that a four-site exchange scheme provided an accurate model for articu...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/1522-2594(200012)44:6<840::aid-mrm4>3.0.co

    authors: Lattanzio PJ,Marshall KW,Damyanovich AZ,Peemoeller H

    更新日期:2000-12-01 00:00:00

  • iDQC anisotropy map imaging for tumor tissue characterization in vivo.

    abstract::Intermolecular double quantum coherences (iDQCs), signals that result from simultaneous transitions of two or more separated spins, are known to produce images that are highly sensitive to subvoxel structure, particularly local anisotropy. Here we demonstrate how iDQCs signal can be used to efficiently detect the anis...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21925

    authors: Branca RT,Chen YM,Mouraviev V,Galiana G,Jenista ER,Kumar C,Leuschner C,Warren WS

    更新日期:2009-04-01 00:00:00

  • A Bayesian approach for 4D flow imaging of aortic valve in a single breath-hold.

    abstract:PURPOSE:To develop and validate a data processing technique that allows phase-contrast MRI-based 4D flow imaging of the aortic valve in a single breath-hold. THEORY AND METHODS:To regularize the ill-posed inverse problem, we extend a recently proposed 2D phase-contrast MRI method to 4D flow imaging. Adopting an empiri...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27386

    authors: Rich A,Potter LC,Jin N,Liu Y,Simonetti OP,Ahmad R

    更新日期:2019-02-01 00:00:00

  • Understanding and optimizing the amplitude modulated control for multiple-slice continuous arterial spin labeling.

    abstract::Multiple-slice perfusion imaging by continuous arterial spin labeling (CASL) is made possible by amplitude modulation (AM) of the labeling RF pulse, but perfusion sensitivity is reduced relative to the single-slice technique. A computer model of the Bloch equations for velocity driven adiabatic fast passage was develo...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20604

    authors: Utting JF,Thomas DL,Gadian DG,Helliar RW,Lythgoe MF,Ordidge RJ

    更新日期:2005-09-01 00:00:00

  • Self-navigated 4D cartesian imaging of periodic motion in the body trunk using partial k-space compressed sensing.

    abstract:PURPOSE:To enable fast and flexible high-resolution four-dimensional (4D) MRI of periodic thoracic/abdominal motion for motion visualization or motion-corrected imaging. METHODS:We proposed a Cartesian three-dimensional k-space sampling scheme that acquires a random combination of k-space lines in the ky/kz plane. A p...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26406

    authors: Küstner T,Würslin C,Schwartz M,Martirosian P,Gatidis S,Brendle C,Seith F,Schick F,Schwenzer NF,Yang B,Schmidt H

    更新日期:2017-08-01 00:00:00

  • Comprehensive approach for correction of motion and distortion in diffusion-weighted MRI.

    abstract::Patient motion and image distortion induced by eddy currents cause artifacts in maps of diffusion parameters computed from diffusion-weighted (DW) images. A novel and comprehensive approach to correct for spatial misalignment of DW imaging (DWI) volumes acquired with different strengths and orientations of the diffusi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10677

    authors: Rohde GK,Barnett AS,Basser PJ,Marenco S,Pierpaoli C

    更新日期:2004-01-01 00:00:00

  • Free breathing three-dimensional late gadolinium enhancement cardiovascular magnetic resonance using outer volume suppressed projection navigators.

    abstract:PURPOSE:To develop a three-dimensional, free-breathing, late gadolinium enhancement (3D FB-LGE) cardiovascular magnetic resonance (CMR) technique, and to compare it with clinically used two-dimensional breath-hold LGE (2D BH-LGE). METHODS:The proposed 3D FB-LGE method consisted of inversion preparation, inversion dela...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26234

    authors: Menon RG,Miller GW,Jeudy J,Rajagopalan S,Shin T

    更新日期:2017-04-01 00:00:00

  • A semiautomatic method for rapid segmentation of velocity-encoded myocardial magnetic resonance imaging data.

    abstract:PURPOSE:To develop a semiautomatic method for rapid segmentation of myocardial tissue phase mapping (TPM) data. METHODS:Manual segmentation of the myocardium was performed at end-diastole and end-systole. The points in both user-defined masks were then automatically tracked over the entire cardiac cycle using temporal...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26486

    authors: Espe EKS,Skårdal K,Aronsen JM,Zhang L,Sjaastad I

    更新日期:2017-09-01 00:00:00

  • Susceptibility mapping in the human brain using threshold-based k-space division.

    abstract::A method for calculating quantitative three-dimensional susceptibility maps from field measurements acquired using gradient echo imaging at high field is presented. This method is based on division of the three-dimensional Fourier transforms of high-pass-filtered field maps by a simple function that is the Fourier tra...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22334

    authors: Wharton S,Schäfer A,Bowtell R

    更新日期:2010-05-01 00:00:00

  • 31P nuclear magnetic resonance study of acute renal dysfunction in rat kidney transplants.

    abstract::31P NMR spectroscopy was used to study renal allografts in rats subjected to allograft rejection, cyclosporine toxicity, ischemia, and ureteral obstruction. Parameters of relative peak areas and intracellular pH were accurately distinguished among the different causes of graft dysfunction. Ureteral obstruction was cle...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910050405

    authors: Shapiro JI,Haug CE,Weil R 3rd,Chan L

    更新日期:1987-10-01 00:00:00

  • Lactate isotopomer analysis by 1H NMR spectroscopy: consideration of long-range nuclear spin-spin interactions.

    abstract::Lactate is a key metabolite and its rates of cellular uptake and release, its production rates from glucose and glycogen, and its interconversion rate with pyruvate are important determinants of cellular energy production. If lactate precursors such as pyruvate and glucose are labeled appropriately with (13)C, (1)H NM...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20075

    authors: Lloyd SG,Zeng H,Wang P,Chatham JC

    更新日期:2004-06-01 00:00:00

  • Perturbation of longitudinal relaxation rate in rotating frame (PLRF) analysis for quantification of chemical exchange saturation transfer signal in a transient state.

    abstract:PURPOSE:To develop a novel analytical method for quantification of chemical exchange saturation transfer (CEST) in the transient state. The proposed method aims to reduce the effects of non-chemical-exchange (non-CE) parameters on the CEST signal, emphasizing the effect of chemical exchange. METHODS:The difference in ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26559

    authors: Wang Y,Zhang Y,Zhao X,Wu B,Gao JH

    更新日期:2017-11-01 00:00:00

  • Evaluation of multicontrast MRI including fat suppression and inversion recovery spin echo for identification of intra-plaque hemorrhage and lipid core in human carotid plaque using the mahalanobis distance measure.

    abstract::Intra-plaque hemorrhage (IPH) and lipid core, characteristics of rupture prone carotid plaques, are often visualized in vivo with MRI using T1 weighted gradient and spin echo, respectively. Increasing magnetic field strength may help to identify IPH and lipid core better. As a proof of concept, automatic segmentation ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23191

    authors: te Boekhorst BC,van 't Klooster R,Bovens SM,van de Kolk KW,Cramer MJ,van Oosterhout MF,Doevendans PA,van der Geest RJ,Pasterkamp G,van Echteld CJ

    更新日期:2012-06-01 00:00:00

  • Contributions of chemical exchange to T1ρ dispersion in a tissue model.

    abstract::Variations in T(1ρ) with locking-field strength (T(1ρ) dispersion) may be used to estimate proton exchange rates. We developed a novel approach utilizing the second derivative of the dispersion curve to measure exchange in a model system of cross-linked polyacrylamide gels. These gels were varied in relative compositi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22947

    authors: Cobb JG,Xie J,Gore JC

    更新日期:2011-12-01 00:00:00