Abstract:
:Diffusion-weighted imaging (DWI) is frequently used to diagnose stroke. However, the origin of the observed reduction in the apparent diffusion coefficient (ADC) in the acute phase following ischemia is not well understood. Although cell swelling is considered to play an important role, it is unclear whether this can completely explain the large ADC decrease. We developed a method to induce in neonatal rat hippocampal slices both osmotic perturbations, which lead to cell swelling, and oxygen/glucose deprivation (OGD), which simulates ischemia. A perfusion system was used to provide the hippocampal slices with nutrients and oxygen to maintain slice viability, which was verified with the use of fluorescent dyes (live/dead staining). Upon induction of OGD, the ADC decreased to approximately 57% of the initial value within 2 hr. The ADC reduction cannot fully be explained by changes due to cell swelling, since these led only to a maximum decrease of approximately 83%. Therefore, in addition to cell swelling, other changes must contribute significantly to the ADC reduction.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
van Pul C,Jennekens W,Nicolay K,Kopinga K,Wijn PFdoi
10.1002/mrm.20353subject
Has Abstractpub_date
2005-02-01 00:00:00pages
348-55issue
2eissn
0740-3194issn
1522-2594journal_volume
53pub_type
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