Trace apparent diffusion coefficients of metabolites in human brain using diffusion weighted magnetic resonance spectroscopy.

Abstract:

:The rotationally invariant trace/3 apparent diffusion coefficients (ADC) of N-acetyl aspartate (NAA), creatine and phosphocreatine (tCr), and choline (Cho) were determined using a diffusion-weighted stimulated echo acquisition mode sequence at 3 T in three separate human brain regions, namely the subcortical white matter, occipital gray matter, and frontal gray matter. The measurement of the mean diffusivity eliminates the dependence of the measured ADC on the direction of the diffusion gradient relative to the tissue microstructure (i.e., anisotropy). Macroscopic brain motions induce phase errors that were compensated for by phasing (zero and first order) on the single average spectrum (zero order on the NAA peak) prior to summing the individual spectra. This method yielded reproducible trace/3 ADC values in the expected range without the use of cardiac gating. The mean diffusivity of NAA (0.14 +/- 0.03 x 10(-3) mm(2)/s) appears to be less than that of tCr (0.17 +/- 0.04 x 10(-3) mm(2)/s) and Cho (0.18 +/- 0.05 x 10(-3) mm(2)/s) in human brain.

journal_name

Magn Reson Med

authors

Ellegood J,Hanstock CC,Beaulieu C

doi

10.1002/mrm.20427

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

1025-32

issue

5

eissn

0740-3194

issn

1522-2594

journal_volume

53

pub_type

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