Abstract:
:Localized 1H NMR homonuclear J editing spectroscopy was used to measure the concentration of 2-pyrrolidinone (PRDN) in the human occipital lobe of five normal and six epileptic subjects taking vigabatrin. PRDN is a lactam cyclization product of gamma-aminobutyric acid (GABA). From a localized volume of 13.5 cm3 in the occipital cortex, the concentration of PRDN ranged from 0.2 to 0.3 micromol/g in normal subjects, whereas in epileptic subjects on vigabatrin PRDN was elevated to 0.6 +/- 0.1 micromol/g. The elevated PRDN in patients on vigabatrin was in accord with raised GABA levels compared with normals. 1H NMR measurements of PRDN will be important in assessment of the role of this metabolite for improved seizure control.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Hyder F,Petroff OA,Mattson RH,Rothman DLdoi
10.1002/(sici)1522-2594(199905)41:5<889::aid-mrm6>subject
Has Abstractpub_date
1999-05-01 00:00:00pages
889-96issue
5eissn
0740-3194issn
1522-2594pii
10.1002/(SICI)1522-2594(199905)41:5<889::AID-MRM6>journal_volume
41pub_type
杂志文章abstract::The magnetization subtraction technique (MS), which is equivalent to the inversion recovery technique in strong magnetic fields, has been implemented in dynamic nuclear polarization-enhanced magnetic resonance imaging (DNPI). The general theoretical basis of the MS method, which can be applied to DNPI or to prepolariz...
journal_title:Magnetic resonance in medicine
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更新日期:2001-03-01 00:00:00
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更新日期:1996-02-01 00:00:00
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更新日期:2012-03-01 00:00:00
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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