In vivo 3D MRI staining of mouse brain after subcutaneous application of MnCl2.

Abstract:

:Follow-up T(1)-weighted 3D gradient-echo MRI (2.35 T) of murine brain in vivo (N = 5) at 120 microm isotropic resolution revealed spatially distinct signal increases 6-48 hr after subcutaneous application of MnCl(2) (20 mg/kg). The effects result from a shortening of the water proton T(1) relaxation time due to the presence of unchelated paramagnetic Mn(2+) ions, which access the brain by systemic circulation and crossing of the blood-brain barrier (BBB). A pronounced Mn(2+)-induced signal enhancement was first seen in structures without a BBB, such as the choroid plexus, pituitary gland, and pineal gland. Within 24 hr after administration, Mn(2+) contrast highlighted the olfactory bulb, inferior colliculi, cerebellum, and the CA3 subfield of the hippocampus. The affinity of Mn(2+) to various brain systems suggests the neuronal uptake of Mn(2+) ions from the extracellular space and subsequent axonal transport. Thus, at least part of the Mn(2+) contrast reflects a functional brain response of behaving animals, for example, in the olfactory system. In vivo MRI staining of the brain by systemic administration of MnCl(2) may contribute to phenotyping mutant mice with morphologic and functional alterations of the central nervous system.

journal_name

Magn Reson Med

authors

Watanabe T,Natt O,Boretius S,Frahm J,Michaelis T

doi

10.1002/mrm.10276

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

852-9

issue

5

eissn

0740-3194

issn

1522-2594

journal_volume

48

pub_type

杂志文章
  • Robust water fat separated dual-echo MRI by phase-sensitive reconstruction.

    abstract:PURPOSE:The purpose of this work was to develop and evaluate a robust water-fat separation method for T1-weighted symmetric two-point Dixon data. THEORY AND METHODS:A method for water-fat separation by phase unwrapping of the opposite-phase images by phase-sensitive reconstruction (PSR) is introduced. PSR consists of ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26488

    authors: Romu T,Dahlström N,Leinhard OD,Borga M

    更新日期:2017-09-01 00:00:00

  • A single acquisition localization technique.

    abstract::A method is demonstrated for detection of magnetization from a selected region within the sensitive volume of a surface coil in a single acquisition. Composite pulses are described which eliminate signals from regions where magnetization is rotated 270 and 450 degrees. There is a loss of 1.3% or less of signal from re...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910030221

    authors: Karczmar GS,Matson GB,Weiner MW

    更新日期:1986-04-01 00:00:00

  • Slice-selective adiabatic magnetization T2 -preparation (SAMPA) for efficient T2 -weighted imaging at ultrahigh field strengths.

    abstract:PURPOSE:At high field, T2 -weighted (T2 w) imaging is limited by transmit field inhomogeneity and increased radiofrequency power deposition. In this work, we introduce SAMPA (Slice-selective Adiabatic Magnetization T2 PrepAration) and demonstrate its use for efficient brain T2 w imaging at 7 Tesla (T). METHODS:SAMPA w...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26067

    authors: Dyvorne H,Balchandani P

    更新日期:2016-12-01 00:00:00

  • iDQC anisotropy map imaging for tumor tissue characterization in vivo.

    abstract::Intermolecular double quantum coherences (iDQCs), signals that result from simultaneous transitions of two or more separated spins, are known to produce images that are highly sensitive to subvoxel structure, particularly local anisotropy. Here we demonstrate how iDQCs signal can be used to efficiently detect the anis...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21925

    authors: Branca RT,Chen YM,Mouraviev V,Galiana G,Jenista ER,Kumar C,Leuschner C,Warren WS

    更新日期:2009-04-01 00:00:00

  • Two-dimensional imaging in a lightweight portable MRI scanner without gradient coils.

    abstract:PURPOSE:As the premiere modality for brain imaging, MRI could find wider applicability if lightweight, portable systems were available for siting in unconventional locations such as intensive care units, physician offices, surgical suites, ambulances, emergency rooms, sports facilities, or rural healthcare sites. METH...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25147

    authors: Cooley CZ,Stockmann JP,Armstrong BD,Sarracanie M,Lev MH,Rosen MS,Wald LL

    更新日期:2015-02-01 00:00:00

  • Fast diffusion tensor imaging and tractography of the whole cervical spinal cord using point spread function corrected echo planar imaging.

    abstract::Diffusion tensor imaging has been used in a number of spinal cord studies, but severe distortions caused by susceptibility induced field inhomogeneities limit its applicability to investigate small volumes within acceptable acquisition times. A way to evaluate image distortions is to map the point spread function of t...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24235

    authors: Lundell H,Barthelemy D,Biering-Sørensen F,Cohen-Adad J,Nielsen JB,Dyrby TB

    更新日期:2013-01-01 00:00:00

  • Dynamic imaging of perfusion in human skeletal muscle during exercise with arterial spin labeling.

    abstract::MR images acquired by using an arterial spin-labeling technique showed spatial and temporal variations of perfusion in the skeletal muscle of exercising humans. Perfusion measurements made during plantar flexion exercise in normal volunteers were consistent with those obtained by traditional techniques reported in the...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199908)42:2<258::aid-mrm7>

    authors: Frank LR,Wong EC,Haseler LJ,Buxton RB

    更新日期:1999-08-01 00:00:00

  • (3)He pO2 mapping is limited by delayed-ventilation and diffusion in chronic obstructive pulmonary disease.

    abstract:PURPOSE:Lung pO2 mapping with (3)He MRI assumes that the sources of signal decay with time during a breath-hold are radiofrequency depolarization and oxygen-dependent T1 relaxation, but the method is sensitive to other sources of spatio-temporal signal change such as diffusion. The purpose of this work was to assess th...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24779

    authors: Marshall H,Parra-Robles J,Deppe MH,Lipson DA,Lawson R,Wild JM

    更新日期:2014-03-01 00:00:00

  • Convex gradient optimization for increased spatiotemporal resolution and improved accuracy in phase contrast MRI.

    abstract:PURPOSE:To evaluate convex gradient optimization (CVX) for increased spatiotemporal resolution and improved accuracy for phase-contrast MRI (PC-MRI). METHODS:A conventional flow-compensated and flow-encoded (FCFE) PC-MRI sequence was compared with a CVX PC-MRI sequence using numerical simulations, flow phantom experim...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25059

    authors: Middione MJ,Wu HH,Ennis DB

    更新日期:2014-12-01 00:00:00

  • MR elastography for evaluating regeneration of tissue-engineered cartilage in an ectopic mouse model.

    abstract:PURPOSE:The purpose of the present study was to apply noninvasive methods for monitoring regeneration and mechanical properties of tissue-engineered cartilage in vivo at different growth stages using MR elastography (MRE). METHODS:Three types of scaffolds, including silk, collagen, and gelatin seeded by human mesenchy...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25745

    authors: Khalilzad-Sharghi V,Han Z,Xu H,Othman SF

    更新日期:2016-03-01 00:00:00

  • Multislice perfusion and perfusion territory imaging in humans with separate label and image coils.

    abstract::An arterial spin labeling technique using separate RF labeling and imaging coils was used to obtain multislice perfusion images of the human brain at 3 T. Continuous RF irradiation at a peak power of 0.3 W was applied to the carotid arteries to adiabatically invert spins. Labeling was achieved without producing magnet...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199906)41:6<1093::aid-mrm4

    authors: Zaharchuk G,Ledden PJ,Kwong KK,Reese TG,Rosen BR,Wald LL

    更新日期:1999-06-01 00:00:00

  • Ultra-rapid gradient echo imaging.

    abstract::A novel ultra-rapid gradient echo (URGE) NMR imaging technique is introduced, which is capable of continuous high resolution 3D scanning while neither subject to fast gradient switching nor excessive RF power deposition. Sampling free induction decays instead of creating spin echoes enables maintaining a workable stea...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910330123

    authors: Heid O,Deimling M,Huk WJ

    更新日期:1995-01-01 00:00:00

  • "PINOT": time-resolved parallel magnetic resonance imaging with a reduced dynamic field of view.

    abstract::This article introduces a novel method named "Parallel Imaging and Noquist in Tandem" (PINOT) for accelerated image acquisition of cine cardiac magnetic resonance imaging. This method combines two prior information formalisms, the SPACE-RIP implementation of parallel imaging and the Noquist method for reduced-data ima...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22696

    authors: Hamilton LH,Fabregat JA,Moratal D,Ramamurthy S,Lerakis S,Parks WJ,Sallee D 3rd,Brummer ME

    更新日期:2011-04-01 00:00:00

  • Intravoxel distribution of DWI decay rates reveals C6 glioma invasion in rat brain.

    abstract::The hypothesis was tested that the intravoxel distribution of water diffusion rates, as measured with a stretched-exponential model of diffusion-weighted imaging (DWI), is a marker of brain tumor invasion. Eight rats underwent intracerebral inoculation of C6 glioma cells. In three rats, cells were labeled with a fluor...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20286

    authors: Bennett KM,Hyde JS,Rand SD,Bennett R,Krouwer HG,Rebro KJ,Schmainda KM

    更新日期:2004-11-01 00:00:00

  • Investigating temporal fluctuations in tumor vasculature with combined carbogen and ultrasmall superparamagnetic iron oxide particle (CUSPIO) imaging.

    abstract::A combined carbogen ultrasmall superparamagnetic iron oxide (USPIO) imaging protocol was developed and applied in vivo in two murine colorectal tumor xenograft models, HCT116 and SW1222, with established disparate vascular morphology, to investigate whether additional information could be extracted from the combinatio...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22779

    authors: Burrell JS,Walker-Samuel S,Baker LC,Boult JK,Ryan AJ,Waterton JC,Halliday J,Robinson SP

    更新日期:2011-07-01 00:00:00

  • Automatic in-line quantitative myocardial perfusion mapping: Processing algorithm and implementation.

    abstract:PURPOSE:Quantitative myocardial perfusion mapping has advantages over qualitative assessment, including the ability to detect global flow reduction. However, it is not clinically available and remains a research tool. Building upon the previously described imaging sequence, this study presents algorithm and implementat...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27954

    authors: Xue H,Brown LAE,Nielles-Vallespin S,Plein S,Kellman P

    更新日期:2020-02-01 00:00:00

  • Apparent diffusion coefficients of the five major metabolites measured in the human brain in vivo at 3T.

    abstract:PURPOSE:To measure the apparent diffusion coefficients (ADC) of five main metabolites in the human brain at 3T with PRESS and STEAM, avoiding measurement biases because of cross-terms. Cross-terms arise from interactions between slice-selection and spoiler gradients in the localized spectroscopy sequence and the diffus...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26969

    authors: Deelchand DK,Auerbach EJ,Marjańska M

    更新日期:2018-06-01 00:00:00

  • Abnormal brain anatomical topological organization of the cognitive-emotional and the frontoparietal circuitry in major depressive disorder.

    abstract:PURPOSE:Despite the increasing understanding of major depressive disorder (MDD) using neuroimaging techniques, the topological organization of anatomical networks underlying MDD remains unclear. METHODS:The topological organization of brain anatomical networks was explored using complex network approaches. Diffusion t...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25036

    authors: Qin J,Wei M,Liu H,Yan R,Luo G,Yao Z,Lu Q

    更新日期:2014-11-01 00:00:00

  • Whole-heart chemical shift encoded water-fat MRI.

    abstract:PURPOSE:To develop and evaluate a free-breathing chemical-shift-encoded (CSE) spoiled gradient-recalled echo (SPGR) technique for whole-heart water-fat imaging at 3 Tesla (T). METHODS:We developed a three-dimensional (3D) multi-echo SPGR pulse sequence with electrocardiographic gating and navigator echoes and evaluate...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24982

    authors: Taviani V,Hernando D,Francois CJ,Shimakawa A,Vigen KK,Nagle SK,Schiebler ML,Grist TM,Reeder SB

    更新日期:2014-09-01 00:00:00

  • Aortic 4D flow: quantification of signal-to-noise ratio as a function of field strength and contrast enhancement for 1.5T, 3T, and 7T.

    abstract:PURPOSE:To investigate for the first time the feasibility of aortic four-dimensional (4D) flow at 7T, both contrast enhanced (CE) and non-CE. To quantify the signal-to-noise ratio (SNR) in aortic 4D flow as a function of field strength and CE with gadobenate dimeglumine (MultiHance). METHODS:Six healthy male volunteer...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25317

    authors: Hess AT,Bissell MM,Ntusi NA,Lewis AJ,Tunnicliffe EM,Greiser A,Stalder AF,Francis JM,Myerson SG,Neubauer S,Robson MD

    更新日期:2015-05-01 00:00:00

  • Investigation of resolution effects using a specialized diffusion tensor phantom.

    abstract:PURPOSE:The clinical potential of the diffusion imaging-based analysis of fine brain structures such as fornix or cingulum is high due to the central role of these structures in psychiatric diseases. However, the quantification of diffusion parameters in fine structures is especially prone to partial volume effects (PV...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24774

    authors: Bach M,Fritzsche KH,Stieltjes B,Laun FB

    更新日期:2014-03-01 00:00:00

  • Investigation of a whole-body receiver coil operating at liquid nitrogen temperatures.

    abstract::This communication describes the design and application of a receiver coil operating at liquid nitrogen temperature and intended as a surface coil in a whole-body imager. Its particular application is seen as the external receiver for parasitic internal or implanted detectors. ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910070211

    authors: Hall AS,Barnard B,McArthur P,Gilderdale DJ,Young IR,Bydder GM

    更新日期:1988-06-01 00:00:00

  • MRI of [2-13 C]Lactate without J-coupling artifacts.

    abstract:PURPOSE:Imaging of [2-13 C]lactate, a metabolic product of [2-13 C]pyruvate, is over considerable interest in hyperpolarized 13 C studies. However, artifact-free imaging of a J-coupled nuclear spin species can be challenging due to the peak-splitting induced by the spin-spin interactions. In this work, two new techniqu...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28532

    authors: Datta K,Spielman D

    更新日期:2021-03-01 00:00:00

  • Experimental confirmation of phase encoding of instantaneous derivatives of position.

    abstract::Previous theoretical reports described the dependence of interpretation of the observed phase of the NMR signal on the time origin(s) of moment calculations and position's Taylor series expansion. This work provides experimental confirmation of predictions derived from that theory. For accelerative motion, experimenta...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910320111

    authors: Duerk JL,Simonetti OP,Hurst GC,Finelli DA

    更新日期:1994-07-01 00:00:00

  • Statistical artifacts in diffusion tensor MRI (DT-MRI) caused by background noise.

    abstract::This work helps elucidate how background noise introduces statistical artifacts in the distribution of the sorted eigenvalues and eigenvectors in diffusion tensor MRI (DT-MRI) data. Although it was known that sorting eigenvalues (principal diffusivities) by magnitude introduces a bias in their sample mean within a hom...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/1522-2594(200007)44:1<41::aid-mrm8>3.0.co;

    authors: Basser PJ,Pajevic S

    更新日期:2000-07-01 00:00:00

  • Template-based field map prediction for rapid whole brain B0 shimming.

    abstract:PURPOSE:In typical MRI protocols, time is spent acquiring a field map to calculate the shim settings for best image quality. We propose a fast template-based field map prediction method that yields near-optimal shims without measuring the field. METHODS:The template-based prediction method uses prior knowledge of the ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27020

    authors: Shi Y,Vannesjo SJ,Miller KL,Clare S

    更新日期:2018-07-01 00:00:00

  • Identification of different lipid phases and calcium phosphate deposits in human carotid artery plaques by MAS NMR spectroscopy.

    abstract::Accumulation of lipids in atherosclerotic plaques causes progressive narrowing of the arterial lumen, often followed by thrombosis and ischemia. Currently several different methods, most requiring disruption of the plaque, are used to study the physical properties of lipids accumulated in plaques, and lipid compositio...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910390204

    authors: Guo W,Morrisett JD,Lawrie GM,DeBakey ME,Hamilton JA

    更新日期:1998-02-01 00:00:00

  • Temporal frequency analysis of dynamic MRI techniques.

    abstract::Dynamic imaging strategies often involve updating certain areas of k-space (i.e., the low spatial frequencies) more frequently than others. However, important dynamic signal changes may occur anywhere in k-space. In this study, a dynamic k-space sampling analysis method was developed to determine the energy error asso...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1074

    authors: Wu Y,Alexander AL

    更新日期:2001-04-01 00:00:00

  • Improved device definition in interventional magnetic resonance imaging using a rotated stripes keyhole acquisition.

    abstract::Keyhole acquisition techniques have been used to reduce image acquisition times primarily in contrast agent studies and via simulation in interventional MRI procedures. More recent simulations have suggested that improved definition of an interventional device [e.g., biopsy needles, radio frequency (RF) electrodes] co...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199909)42:3<554::aid-mrm18

    authors: Hwang KP,Lim J,Wendt M,Merkle E,Lewin JS,Duerk JL

    更新日期:1999-09-01 00:00:00

  • High resolution hyperpolarized 13 C MRSI using SPICE at 9.4T.

    abstract:PURPOSE:To test the feasibility of using the SPICE (SPectroscopic Imaging by exploiting spatiospectral CorrElation) technique, which uses the partial separability of spectroscopic data, for high resolution hyperpolarized (HP) 13 C spectroscopic imaging. METHODS:Numerical simulations were performed to investigate the i...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27061

    authors: Lee H,Song JE,Shin J,Joe E,Joo CG,Choi YS,Song HT,Kim DH

    更新日期:2018-08-01 00:00:00