High-resolution contrast-enhanced MRI of atherosclerosis with digital cardiac and respiratory gating in mice.

Abstract:

:Atherosclerosis initially develops predominantly at the aortic root and carotid origin, where effective visualization in mice requires efficient cardiac and respiratory gating. The present study sought to first compare the high-resolution MRI gating performance of two digital gating strategies using: 1) separate cardiac and respiratory signals (double-sensor); and 2) a single-sensor cardiorespiratory signal (ECG demodulation), and second, to apply an optimized processing technique to dynamic contrast-enhanced (CE) carotid origin vessel-wall imaging in mice. High-resolution MR mouse heart and aortic arch images were acquired by ECG signal detection, digital signal processing, and gating signal generation modeled using Simulink (MathWorks, USA). Double-sensor gating used a respiratory sensor while single-sensor gating used breathing-modulated ECG to generate a demodulated respiratory signal. Pre- and postcontrast T(1)-weighted images were acquired to evaluate vessel-wall enhancement with a gadolinium blood-pool agent (P792; Guerbet, France) at the carotid origin in vivo in ApoE(-/-) and C57BL/6 mice, using the optimized cardiorespiratory gating processing technique. Both strategies provided images with improved spatial resolution, less artifacts, and 100% correct transistor-to-transistor logic (TTL) signals. Image quality allowed vessel-wall enhancement measurement in all the ApoE(-/-) mice, with maximal (32%) enhancement 27 min postinjection. The study demonstrated the efficiency of both cardiorespiratory gating strategies for dynamic contrast-enhanced vessel-wall imaging.

journal_name

Magn Reson Med

authors

Alsaid H,Sabbah M,Bendahmane Z,Fokapu O,Felblinger J,Desbleds-Mansard C,Corot C,Briguet A,Crémillieux Y,Canet-Soulas E

doi

10.1002/mrm.21308

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

1157-63

issue

6

eissn

0740-3194

issn

1522-2594

journal_volume

58

pub_type

杂志文章
  • Manifold Learning in MR spectroscopy using nonlinear dimensionality reduction and unsupervised clustering.

    abstract:PURPOSE:To investigate whether nonlinear dimensionality reduction improves unsupervised classification of (1) H MRS brain tumor data compared with a linear method. METHODS:In vivo single-voxel (1) H magnetic resonance spectroscopy (55 patients) and (1) H magnetic resonance spectroscopy imaging (MRSI) (29 patients) dat...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25447

    authors: Yang G,Raschke F,Barrick TR,Howe FA

    更新日期:2015-09-01 00:00:00

  • Human whole-blood (1)H2O longitudinal relaxation with normal and high-relaxivity contrast reagents: influence of trans-cell-membrane water exchange.

    abstract:PURPOSE:Accurate characterization of contrast reagent (CR) longitudinal relaxivity in whole blood is required to predict arterial signal intensity in contrast-enhanced MR angiography (CE-MRA). This study measured the longitudinal relaxation rate constants (R1 ) over a concentration range for non-protein-binding and pro...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25064

    authors: Wilson GJ,Woods M,Springer CS Jr,Bastawrous S,Bhargava P,Maki JH

    更新日期:2014-12-01 00:00:00

  • Motion corrected water/fat whole-heart coronary MR angiography with 100% respiratory efficiency.

    abstract:PURPOSE:To develop a framework for respiratory motion-corrected 3D whole-heart water/fat coronary MR angiography (CMRA) at 3T with reduced and predictable scan time. METHODS:A 3D dual-echo acquisition and respiratory motion-corrected reconstruction framework for water/fat CMRA imaging was developed. The acquisition se...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27732

    authors: Munoz C,Cruz G,Neji R,Botnar RM,Prieto C

    更新日期:2019-08-01 00:00:00

  • Ischemia-induced ADC changes are larger than osmotically-induced ADC changes in a neonatal rat hippocampus model.

    abstract::Diffusion-weighted imaging (DWI) is frequently used to diagnose stroke. However, the origin of the observed reduction in the apparent diffusion coefficient (ADC) in the acute phase following ischemia is not well understood. Although cell swelling is considered to play an important role, it is unclear whether this can ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20353

    authors: van Pul C,Jennekens W,Nicolay K,Kopinga K,Wijn PF

    更新日期:2005-02-01 00:00:00

  • Effect of feature extraction for brain tumor classification based on short echo time 1H MR spectra.

    abstract::This study examines the effect of feature extraction methods prior to automated pattern recognition based on magnetic resonance spectroscopy (MRS) for brain tumor diagnosis. Since individual inspection of spectra is time-consuming and requires specific spectroscopic expertise, the introduction of clinical decision sup...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21626

    authors: Luts J,Poullet JB,Garcia-Gomez JM,Heerschap A,Robles M,Suykens JA,Van Huffel S

    更新日期:2008-08-01 00:00:00

  • Steady state of echo-shifted sequences with radiofrequency phase cycling.

    abstract::Due to a delayed echo-formation, echo-shifted gradient echo sequences (ES-GRE) allow for an enhanced T(2)*-weighting at short repetition times. While they are in use with and without RF spoiling, analytical solutions are only known for the latter. The signal formation in the former could only be assessed in approximat...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21010

    authors: Ganter C

    更新日期:2006-10-01 00:00:00

  • Effect of distortion corrections on the tractography quality in spinal cord diffusion-weighted imaging.

    abstract:PURPOSE:To assess the impact of a different distortion correction (DC) method and patient geometry (sagittal balance) on the quality of spinal cord tractography rendering according to different tractography approaches. METHODS:Forty-four adults free of spinal cord diseases underwent cervical diffusion-weighted imaging...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28665

    authors: Dauleac C,Bannier E,Cotton F,Frindel C

    更新日期:2021-01-21 00:00:00

  • Phosphorus-31 magnetic resonance spectroscopy in humans by spectroscopic imaging: localized spectroscopy and metabolite imaging.

    abstract::In in vivo phosphorus magnetic resonance spectroscopy (MRS), spectroscopic imaging (SI) can be used as a flexible localization technique, producing spectra from multiple volumes in a single examination. Presented here are phosphorus SI studies of human organs in which a selective-volume SI reconstruction was used rath...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910120302

    authors: Twieg DB,Meyerhoff DJ,Hubesch B,Roth K,Sappey-Marinier D,Boska MD,Gober JR,Schaefer S,Weiner MW

    更新日期:1989-12-01 00:00:00

  • High resolution quantitative relaxation and diffusion MRI of three different experimental brain tumors in rat.

    abstract::The potential of quantitative parameter images of the relaxation times T1 and T2, the proton density rho and the apparent diffusion coefficient (ADC) to characterize three different experimental rat brain tumors (F98 glioma, RN6 Schwannoma, and E376 neuroblastoma) was studied. All parameter values, as determined in hi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910340608

    authors: Eis M,Els T,Hoehn-Berlage M

    更新日期:1995-12-01 00:00:00

  • Efficient visualization of vascular territories in the human brain by cycled arterial spin labeling MRI.

    abstract::Intracranial vascular territories are usually visualized with the use of angiographic techniques. However, because it is difficult to visualize the distal vascular bed with any angiographic technique, it is also difficult to infer the parenchymal borders of vascular territories. Arterial spin labeling (ASL) MRI provid...

    journal_title:Magnetic resonance in medicine

    pub_type: 临床试验,杂志文章

    doi:10.1002/mrm.20998

    authors: Günther M

    更新日期:2006-09-01 00:00:00

  • Localized two-dimensional shift correlated spectroscopy in humans at 2 Tesla.

    abstract::A method for the acquisition of localized 2D shift-correlated spectra, based on the combination of the stimulated-echo volume-selection and gradient-enhanced COSY experiments, is described. The sequence can be modified to perform a number of localized experiments including HOHAHA and DQF-COSY. The method is demonstrat...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910320216

    authors: Brereton IM,Galloway GJ,Rose SE,Doddrell DM

    更新日期:1994-08-01 00:00:00

  • T2 relaxation-time mapping in healthy and diseased skeletal muscle using extended phase graph algorithms.

    abstract:PURPOSE:Multi-echo spin-echo (MSE) transverse relaxometry mapping using multi-component models is used to study disease activity in neuromuscular disease by assessing the T2 of the myocytic component (T2water ). Current extended phase graph algorithms are not optimized for fat fractions above 50% and the effects of ina...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28290

    authors: Keene KR,Beenakker JM,Hooijmans MT,Naarding KJ,Niks EH,Otto LAM,van der Pol WL,Tannemaat MR,Kan HE,Froeling M

    更新日期:2020-11-01 00:00:00

  • Gradient, high-resolution, magic-angle spinning nuclear magnetic resonance spectroscopy of human adipocyte tissue.

    abstract::The recently developed technique of gradient, high-resolution magic-angle spinning NMR (g-hr-MAS-NMR) spectroscopy was applied to the study of ex vivo human lipoma and liposarcoma tissue. Compared with conventional 1H-NMR, the g-hr-MAS method yielded a large improvement in spectral resolution and permitted the detecti...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910380307

    authors: Millis KK,Maas WE,Cory DG,Singer S

    更新日期:1997-09-01 00:00:00

  • Effects of anesthesia on renal function and metabolism in rats assessed by hyperpolarized MRI.

    abstract:PURPOSE:Anesthesia is necessary for most animal studies requiring invasive procedures. It is well documented that various types of anesthesia modulate a wide variety of important metabolic and functional processes in the body, and as such, represent a potential limitation in the study design. In the present study, we a...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27165

    authors: Qi H,Mariager CØ,Lindhardt J,Nielsen PM,Stødkilde-Jørgensen H,Laustsen C

    更新日期:2018-11-01 00:00:00

  • Cardiac real-time imaging using SENSE. SENSitivity Encoding scheme.

    abstract::Sensitivity encoding is used to improve the performance of real-time MRI. The encoding efficiency of single-shot and segmented echo-planar imaging is tripled by means of a 6-element receiver coil array. The feasibility of this approach is verified for double oblique cardiac real-time imaging of human subjects at rest ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(200002)43:2<177::aid-mrm3>

    authors: Weiger M,Pruessmann KP,Boesiger P

    更新日期:2000-02-01 00:00:00

  • Parallel excitation for B-field insensitive fat-saturation preparation.

    abstract::Multichannel transmission has the potential to improve many aspects of MRI through a new paradigm in excitation. In this study, multichannel transmission is used to address the effects that variations in B(0) homogeneity have on fat-saturation preparation through the use of the frequency, phase, and amplitude degrees ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23238

    authors: Heilman JA,Derakhshan JD,Riffe MJ,Gudino N,Tkach J,Flask CA,Duerk JL,Griswold MA

    更新日期:2012-08-01 00:00:00

  • Sliding time of flight: sliding time of flight MR angiography using a dynamic image reconstruction method.

    abstract:PURPOSE:To obtain three-dimensional (3D) MR angiography having high contrast between vessel and stationary background tissue, a novel technique called sliding time of flight (TOF) is proposed. METHODS:The proposed method relies on the property that flow-related enhancement (FRE) is maximized at the blood-entering slic...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25215

    authors: Choi J,Seo H,Lim Y,Han Y,Park H

    更新日期:2015-03-01 00:00:00

  • Pulmonary perfusion: qualitative assessment with dynamic contrast-enhanced MRI using ultra-short TE and inversion recovery turbo FLASH.

    abstract::The accurate assessment of pulmonary perfusion is especially important in the evaluation of patients with suspected pulmonary embolism, a common and potentially lethal disorder that can be treated by aggressive anticoagulation. In this study, we demonstrate for the first time the use of MR to image pulmonary perfusion...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910360402

    authors: Hatabu H,Gaa J,Kim D,Li W,Prasad PV,Edelman RR

    更新日期:1996-10-01 00:00:00

  • Passive tracking of catheters and guidewires by contrast-enhanced MR fluoroscopy.

    abstract::Passive MR tracking of catheters and guidewires is usually done by dynamically imaging a single thick slab, subtracting a baseline image, and combining the result with a previously acquired MR angiogram. In the in vitro and in vivo experiments reported here, it is demonstrated that this approach may be greatly simplif...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/1522-2594(200101)45:1<17::aid-mrm1003>3.0.

    authors: Bakker CJ,Bos C,Weinmann HJ

    更新日期:2001-01-01 00:00:00

  • In vivo multiple-mouse MRI at 7 Tesla.

    abstract::We developed a live high-field multiple-mouse magnetic resonance imaging method to increase the throughput of imaging studies involving large numbers of mice. Phantom experiments were performed in 7 shielded radiofrequency (RF) coils for concurrent imaging on a 7 Tesla MRI scanner outfitted with multiple transmit and ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20683

    authors: Bock NA,Nieman BJ,Bishop JB,Mark Henkelman R

    更新日期:2005-11-01 00:00:00

  • RACER-GRASP: Respiratory-weighted, aortic contrast enhancement-guided and coil-unstreaking golden-angle radial sparse MRI.

    abstract:PURPOSE:To develop and evaluate a novel dynamic contrast-enhanced imaging technique called RACER-GRASP (Respiratory-weighted, Aortic Contrast Enhancement-guided and coil-unstReaking Golden-angle RAdial Sparse Parallel) MRI that extends GRASP to include automatic contrast bolus timing, respiratory motion compensation, a...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27002

    authors: Feng L,Huang C,Shanbhogue K,Sodickson DK,Chandarana H,Otazo R

    更新日期:2018-07-01 00:00:00

  • Quantitative susceptibility mapping using single-shot echo-planar imaging.

    abstract:PURPOSE:To perform quantitative susceptibility mapping (QSM) in negligible acquisition time and apply it to measuring iron-rich subcortical gray matter. METHODS:Whole brain QSM was performed using single-shot gradient echo-planar imaging (EPI) in under 7 seconds on a standard 1.5 T system for imaging brain iron in sub...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25316

    authors: Sun H,Wilman AH

    更新日期:2015-05-01 00:00:00

  • Joint image reconstruction and sensitivity estimation in SENSE (JSENSE).

    abstract::Parallel magnetic resonance imaging (pMRI) using multichannel receiver coils has emerged as an effective tool to reduce imaging time in various applications. However, the issue of accurate estimation of coil sensitivities has not been fully addressed, which limits the level of speed enhancement achievable with the tec...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21245

    authors: Ying L,Sheng J

    更新日期:2007-06-01 00:00:00

  • Linear combination of multiecho data: short T2 component selection.

    abstract::The myelin sheath, which is wrapped around the axons in the brain, can be affected by many diseases, resulting in cognitive and physical disability. Other work showed water in the myelin sheath has a T2 approximately 15 ms. The current standard technique to estimate the fraction of myelin water in vivo is to collect m...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10713

    authors: Jones CK,Xiang QS,Whittall KP,MacKay AL

    更新日期:2004-03-01 00:00:00

  • Fast design of local N-gram-specific absorption rate-optimized radiofrequency pulses for parallel transmit systems.

    abstract::Designing multidimensional radiofrequency pulses for clinical application must take into account the local specific absorption rate (SAR) as controlling the global SAR does not guarantee suppression of hot spots. The maximum peak SAR, averaged over an N grams cube (local NgSAR), must be kept under certain safety limit...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23049

    authors: Sbrizzi A,Hoogduin H,Lagendijk JJ,Luijten P,Sleijpen GL,van den Berg CA

    更新日期:2012-03-01 00:00:00

  • 3D coronary artery imaging with phase reordering for improved scan efficiency.

    abstract::Three-dimensional (3D) coronary imaging has the potential to overcome problems resulting from vessel tortuosity and to reduce partial volume effects. With these techniques, however, acquisition times are long and respiratory motion artifacts problematical. This work describes the development of a method that applies p...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199903)41:3<555::aid-mrm19

    authors: Jhooti P,Keegan J,Gatehouse PD,Collins S,Rowe A,Taylor AM,Firmin DN

    更新日期:1999-03-01 00:00:00

  • Experimental encephalomyelitis modulates inositol and taurine in the spinal cord of Biozzi mice.

    abstract::In this high resolution magnetic resonance spectroscopic study of experimental allergic encephalomyelitis (EAE) and Semliki Forest virus (SFV) infection of the Biozzi AB/H mouse, marked increases in the initially low levels of N-trimethyl compounds in the spinal cord were observed during probable demyelinating episode...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910320603

    authors: Preece NE,Amor S,Baker D,Gadian DG,O'Neill JK,Urenjak J

    更新日期:1994-12-01 00:00:00

  • Spiral trajectory design: a flexible numerical algorithm and base analytical equations.

    abstract:PURPOSE:Spiral-based trajectories for magnetic resonance imaging can be advantageous, but are often cumbersome to design or create. This work presents a flexible numerical algorithm for designing trajectories based on explicit definition of radial undersampling, and also gives several analytical expressions for charact...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24675

    authors: Pipe JG,Zwart NR

    更新日期:2014-01-01 00:00:00

  • Single-shot localized echo-planar imaging (STEAM-EPI) at 4.7 tesla.

    abstract::The resolution and homogeneity limitations of echo-planar imaging (EPI) are overcome by zoom imaging of an easily shimmed localized volume. Use of the stimulated echo enables single-shot localization. In vivo 0.5-mm resolution EPI images of selected regions of a cat brain at 4.7 T are presented. ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910140225

    authors: Turner R,von Kienlin M,Moonen CT,van Zijl PC

    更新日期:1990-05-01 00:00:00

  • Broadband slab selection with B1+ mitigation at 7T via parallel spectral-spatial excitation.

    abstract::Chemical shift imaging benefits from signal-to-noise ratio (SNR) and chemical shift dispersion increases at stronger main field such as 7 Tesla, but the associated shorter radiofrequency (RF) wavelengths encountered require B1+ mitigation over both the spatial field of view (FOV) and a specified spectral bandwidth. Th...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21834

    authors: Setsompop K,Alagappan V,Gagoski BA,Potthast A,Hebrank F,Fontius U,Schmitt F,Wald LL,Adalsteinsson E

    更新日期:2009-02-01 00:00:00