Abstract:
:We developed a live high-field multiple-mouse magnetic resonance imaging method to increase the throughput of imaging studies involving large numbers of mice. Phantom experiments were performed in 7 shielded radiofrequency (RF) coils for concurrent imaging on a 7 Tesla MRI scanner outfitted with multiple transmit and receive channels to confirm uniform signal-to-noise ratio and minimal ghost artifacts across images from the different RF coils. Grid phantoms were used to measure image distortion in different positions in the coils. The brains of 7 live mice were imaged in 3D in the RF coil array, and a second array of 16 RF coils was used to 3D image the whole bodies of 16 fixed, contrast agent-perfused mice. The images of the 7 live mouse brains at 156 microm isotropic resolution and the 16 whole fixed mice at 100 microm isotropic resolution were of high quality and free of artifacts. We have thus shown that multiple-mouse MRI increases throughput for live and fixed mouse experiments by a factor equaling the number of RF coils in the scanner.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Bock NA,Nieman BJ,Bishop JB,Mark Henkelman Rdoi
10.1002/mrm.20683subject
Has Abstractpub_date
2005-11-01 00:00:00pages
1311-6issue
5eissn
0740-3194issn
1522-2594journal_volume
54pub_type
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