Per-subject characterization of bolus width in pulsed arterial spin labeling using bolus turbo sampling.

Abstract:

:Quantification of cerebral blood flow using QUIPSSII pulsed arterial spin labeling requires that the QUIPSS saturation delay TI1 is shorter than the natural temporal bolus width. Yet the duration of the bolus of tagged spins entering the region of interest varies during vasoactive stimuli such as gaseous challenges or across subjects due to differences in blood velocity or vessel geometry. A new technique, bolus turbo sampling, to rapidly measure the duration of the inflowing bolus is presented. It allows to optimize the arterial spin labeling acquisition to ensure reliable quantification of perfusion while maximizing the arterial spin labeling signal by avoiding the use of unnecessarily short label durations. The average bolus width measured in the right and left middle cerebral artery territories using the bolus turbo sampling technique has a repeatability coefficient of 75 ms and correlates significantly with the TI1,max determined from a novel multi-TI1 protocol (R=0.65, P<0.05). The possibility to measure the bolus width under hypercapnia is demonstrated.

journal_name

Magn Reson Med

authors

Villien M,Chipon E,Troprès I,Bouvier J,Cantin S,Chechin D,Le Bas JF,Krainik A,Warnking JM

doi

10.1002/mrm.24412

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

1677-82

issue

6

eissn

0740-3194

issn

1522-2594

journal_volume

69

pub_type

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