Multi-band MR fingerprinting (MRF) ASL imaging using artificial-neural-network trained with high-fidelity experimental data.

Abstract:

PURPOSE:We aim to leverage the power of deep-learning with high-fidelity training data to improve the reliability and processing speed of hemodynamic mapping with MR fingerprinting (MRF) arterial spin labeling (ASL). METHODS:A total of 15 healthy subjects were studied on a 3T MRI. Each subject underwent 10 runs of a multi-band multi-slice MRF-ASL sequence for a total scan time of approximately 40 min. MRF-ASL images were averaged across runs to yield a set of high-fidelity data. Training of a fully connected artificial neural network (ANN) was then performed using these data. The results from ANN were compared to those of dictionary matching (DM), ANN trained with single-run experimental data and with simulation data. Initial clinical performance of the technique was also demonstrated in a Moyamoya patient. RESULTS:The use of ANN reduced the processing time of MRF-ASL data to 3.6 s, compared to DM of 3 h 12 min. Parametric values obtained with ANN and DM were strongly correlated (R2 between 0.84 and 0.96). Results obtained from high-fidelity ANN were substantially more reliable compared to those from DM or single-run ANN. Voxel-wise coefficient of variation (CoV) of high-fidelity ANN, DM, and single-run ANN was 0.15 ± 0.08, 0.41 ± 0.20, 0.30 ± 0.16, respectively, for cerebral blood flow and 0.11 ± 0.06, 0.20 ± 0.19, 0.15 ± 0.10, respectively, for bolus arrival time. In vivo data trained ANN also outperformed ANN trained with simulation data. The superior performance afforded by ANN allowed more conspicuous depiction of hemodynamic abnormalities in Moyamoya patient. CONCLUSION:Deep-learning-based parametric reconstruction improves the reliability of MRF-ASL hemodynamic maps and reduces processing time.

journal_name

Magn Reson Med

authors

Fan H,Su P,Huang J,Liu P,Lu H

doi

10.1002/mrm.28560

subject

Has Abstract

pub_date

2021-04-01 00:00:00

pages

1974-1985

issue

4

eissn

0740-3194

issn

1522-2594

journal_volume

85

pub_type

杂志文章
  • Aortic wall shear stress in Marfan syndrome.

    abstract::The aim of this study was to quantify changes in thoracic aortic wall shear stress (WSS) in asymptomatic patients with Marfan syndrome (MFS) compared with healthy controls. WSS in the thoracic aorta was quantified based on time-resolved 3D phase contrast MRI with three-directional velocity encoding (4D flow MRI, tempo...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24562

    authors: Geiger J,Arnold R,Herzer L,Hirtler D,Stankovic Z,Russe M,Langer M,Markl M

    更新日期:2013-10-01 00:00:00

  • In vivo and ex vivo MR imaging of slowly cycling melanoma cells.

    abstract::Slowly cycling cells are believed to play a critical role in tumor progression and metastatic dissemination. The goal of this study was to develop a method for in vivo detection of slowly cycling cells. To distinguish these cells from more rapidly proliferating cells that constitute the vast majority of cells in tumor...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22917

    authors: Magnitsky S,Roesch A,Herlyn M,Glickson JD

    更新日期:2011-11-01 00:00:00

  • Increasing spoiling efficiency in RF-spoiled gradient echo sequences by averaging of RF phase-cycle-adapted k-spaces.

    abstract::A method is presented that improves the effectiveness of RF-spoiling whenever an image consists of the averaging of several identical single acquisitions. Using this method, it becomes possible to reduce the necessary moment of the spoiler gradient by a factor equal to the number of averages. The idea is to perform th...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22882

    authors: Leupold J,Hennig J

    更新日期:2011-10-01 00:00:00

  • Quantitative liver 31P magnetic resonance spectroscopy at 3T on a clinical scanner.

    abstract:PURPOSE:The aims of this study were (i) to establish a robust and fast method to quantify hepatocellular phosphorus compounds in molar concentration on a 3T clinical scanner, (ii) to evaluate its reproducibility, and (iii) to test its feasibility for a use in large cohort studies. METHOD:Proton-decoupled (31) P magnet...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24835

    authors: Laufs A,Livingstone R,Nowotny B,Nowotny P,Wickrath F,Giani G,Bunke J,Roden M,Hwang JH

    更新日期:2014-05-01 00:00:00

  • Three-dimensional MRI with an undersampled spherical shells trajectory.

    abstract::The shells trajectory is a 3D data acquisition method with improved efficiency compared to Cartesian sampling. It is a true center-out trajectory that does not repeatedly resample the center of k-space, and also offers advantages for motion correction. This work demonstrates that k-space undersampling can be combined ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20977

    authors: Shu Y,Riederer SJ,Bernstein MA

    更新日期:2006-09-01 00:00:00

  • Multislice perfusion and perfusion territory imaging in humans with separate label and image coils.

    abstract::An arterial spin labeling technique using separate RF labeling and imaging coils was used to obtain multislice perfusion images of the human brain at 3 T. Continuous RF irradiation at a peak power of 0.3 W was applied to the carotid arteries to adiabatically invert spins. Labeling was achieved without producing magnet...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199906)41:6<1093::aid-mrm4

    authors: Zaharchuk G,Ledden PJ,Kwong KK,Reese TG,Rosen BR,Wald LL

    更新日期:1999-06-01 00:00:00

  • Sensitivity of MR diffusion measurements to variations in intracellular structure: effects of nuclear size.

    abstract::Magnetic resonance imaging measurements of the apparent rate of water diffusion in tumors are sensitive to variations in tissue cellularity, which have been shown useful for characterizing tumors and their responses to treatments. However, because of technical limitations on most MRI systems, conventional pulse gradie...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21793

    authors: Xu J,Does MD,Gore JC

    更新日期:2009-04-01 00:00:00

  • Multi-angle ratiometric approach to measure chemical exchange in amide proton transfer imaging.

    abstract::Amide proton transfer imaging, a specific form of chemical exchange saturation transfer imaging, has previously been applied to studies of acute ischemic acidosis, stroke, and cancer. However, interpreting the resulting contrast is complicated by its dependence on the exchange rate between amides and water, the amide ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23276

    authors: Zu Z,Janve VA,Li K,Does MD,Gore JC,Gochberg DF

    更新日期:2012-09-01 00:00:00

  • T1 measurements in the human myocardium: the effects of magnetization transfer on the SASHA and MOLLI sequences.

    abstract:PURPOSE:Quantitative mapping of the native T1 of the heart using the modified look-locker inversion recovery (MOLLI) technique provides high quality diagnostic information without requiring contrast agents. Previous work has considered the effects of T2 relaxation on MOLLI T1 measurements, finding that the T1 measured ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24867

    authors: Robson MD,Piechnik SK,Tunnicliffe EM,Neubauer S

    更新日期:2013-09-01 00:00:00

  • Free-breathing volumetric fat/water separation by combining radial sampling, compressed sensing, and parallel imaging.

    abstract:PURPOSE:Conventional fat/water separation techniques require that patients hold breath during abdominal acquisitions, which often fails and limits the achievable spatial resolution and anatomic coverage. This work presents a novel approach for free-breathing volumetric fat/water separation. METHODS:Multiecho data are ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26392

    authors: Benkert T,Feng L,Sodickson DK,Chandarana H,Block KT

    更新日期:2017-08-01 00:00:00

  • Dynamic 13C NMR analysis of pyruvate and lactate oxidation in the in vivo canine myocardium: evidence of reduced utilization with increased work.

    abstract::In this work, substrate selection was monitored in the left ventricle of the canine myocardium by following pyruvate and lactate oxidation under in vivo conditions at basal and elevated workloads. These studies were conducted in the open chest model using dynamic 13C NMR techniques in the presence and absence of dichl...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910380608

    authors: Rath DP,Zhu H,Tong X,Jiang Z,Hamlin RL,Robitaille PM

    更新日期:1997-12-01 00:00:00

  • Measurement of changes in cerebral blood volume in spontaneously hypertensive rats following L-arginine infusion using dynamic susceptibility contrast MRI.

    abstract::To understand whether the NO-dependent vasodilator L-arginine was effective upon a chronically hypertensive cerebral capillary endothelium, dynamic susceptibility contrast MRI was used to measure the relative cerebral blood volume (rCBV) changes in nonischemic spontaneously hypertensive rats (SHRs). rCBV was measured ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910390123

    authors: Caramia F,Yoshida T,Hamberg LM,Huang Z,Hunter G,Wanke I,Zaharchuk G,Moskowitz MA,Rosen BR

    更新日期:1998-01-01 00:00:00

  • Atraumatic quantitation of cerebral perfusion in cats by 19F magnetic resonance imaging.

    abstract::We have noninvasively produced low-resolution, quantitative nuclear magnetic resonance images of cerebral blood flow in 2-ml voxels in eight cats. Typical signal-to-noise of 4 to 1 was obtained in cerebral voxels in 16.5-s epochs. Mean flow during normocapnia (paCO2 = 39 +/- 4 mm Hg) and hypercapnia (paCO2 = 62 +/- 4 ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910280105

    authors: Branch CA,Ewing JR,Helpern JA,Ordidge RJ,Butt S,Welch KM

    更新日期:1992-11-01 00:00:00

  • Simplified synthesis and relaxometry of magnetoferritin for magnetic resonance imaging.

    abstract::Magnetoferritin nanoparticles have been developed as high-relaxivity, functional contrast agents for MRI. Several previous techniques have relied on unloading native ferritin and re-incorporation of iron into the core, often resulting in a polydisperse sample. Here, a simplified technique is developed using commercial...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22526

    authors: Jordan VC,Caplan MR,Bennett KM

    更新日期:2010-11-01 00:00:00

  • Group sparse reconstruction using intensity-based clustering.

    abstract::Compressed sensing has been of great interest to speed up the acquisition of MR images. The k-t group sparse (k-t GS) method has recently been introduced for dynamic MR images to exploit not just the sparsity, as in compressed sensing, but also the spatial group structure in the sparse representation. k-t GS achieves ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24333

    authors: Prieto C,Usman M,Wild JM,Kozerke S,Batchelor PG,Schaeffter T

    更新日期:2013-04-01 00:00:00

  • Intracellular bimodal nanoparticles based on quantum dots for high-field MRI at 21.1 T.

    abstract::Multimodal, biocompatible contrast agents for high magnetic field applications represent a new class of nanomaterials with significant potential for tracking of fluorescence and MR in vitro and vivo. Optimized for high-field MR applications-including biomedical imaging at 21.1 T, the highest magnetic field available f...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22441

    authors: Rosenberg JT,Kogot JM,Lovingood DD,Strouse GF,Grant SC

    更新日期:2010-09-01 00:00:00

  • Radiofrequency pulse design for the selective excitation of dissolved 129Xe.

    abstract:PURPOSE:To optimize radiofrequency (RF) pulses for the selective excitation of dissolved phase (129)Xe that take into account the very short T2*, while simultaneously, minimally exciting the much larger gas signal. METHODS:Numerical simulations of Shinnar le-Roux pulses and binomial coefficient composite-element pulse...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25089

    authors: Leung G,Norquay G,Schulte RF,Wild JM

    更新日期:2015-01-01 00:00:00

  • Minimization of dead-periods in MRI pulse sequences for imaging oblique planes.

    abstract::With the advent of breath-hold MR cardiac imaging techniques, the minimization of TR and TE for oblique planes has become a critical issue. The slew rates and maximum currents of gradient amplifiers limit the minimum possible TR and TE by adding dead-periods to the pulse sequences. We propose a method of designing gra...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910320613

    authors: Atalar E,McVeigh ER

    更新日期:1994-12-01 00:00:00

  • Radioactive microsphere validation of a volume localized continuous saturation perfusion measurement.

    abstract::Detre et al. (Magn. Reson. Med. 23, 37-45 (1992)) and Zhang et al., (Magn. Reson. Med. 25, 362 (1992)) have recently demonstrated a technique for the measurement of regional cerebral blood flow (rCBF) based on the continuous saturation (or inversion) of the arterial blood supply to the brain in rats at 4.7 T. In the w...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910310208

    authors: Walsh EG,Minematsu K,Leppo J,Moore SC

    更新日期:1994-02-01 00:00:00

  • Application of phase rotation to STRESS localization scheme at 3 T.

    abstract:PURPOSE:Application of phase rotation to the STRESS (=STEAM+PRESS) localization scheme, to shorten echo time, minimize J-coupling dephasing and estimate B1+ inhomogeneity. STRESS (=STEAM + PRESS) simultaneously refocuses and acquires the double spin echo (SE123 ) and stimulated echo (STE- ) pathways, combining PRESS-li...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26911

    authors: Volovyk O,Tal A

    更新日期:2018-05-01 00:00:00

  • Removal of nuisance signals from limited and sparse 1H MRSI data using a union-of-subspaces model.

    abstract:PURPOSE:To remove nuisance signals (e.g., water and lipid signals) for (1) H MRSI data collected from the brain with limited and/or sparse (k, t)-space coverage. METHODS:A union-of-subspace model is proposed for removing nuisance signals. The model exploits the partial separability of both the nuisance signals and the...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25635

    authors: Ma C,Lam F,Johnson CL,Liang ZP

    更新日期:2016-02-01 00:00:00

  • Wideband myocardial perfusion pulse sequence for imaging patients with a cardiac implantable electronic device.

    abstract:PURPOSE:To develop a wideband cardiac perfusion pulse sequence and test whether it is capable of suppressing image artifacts in patients with a cardiac implantable electronic device (CIED), while not exceeding the specific absorption rate (SAR) limit (2.0 W/kg). METHODS:A wideband perfusion pulse sequence was develope...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27458

    authors: Hong K,Collins JD,Knight BP,Carr JC,Lee DC,Kim D

    更新日期:2019-02-01 00:00:00

  • Three-dimensional MRI with independent slab excitation and encoding.

    abstract::Three-dimensional MRI is typically performed with the same orientation for radiofrequency slab excitation and slab select phase encoding. We introduce independent slab excitation and encoding to create a new degree of freedom in three-dimensional MRI, which is the angular relationship between the prescribed excitation...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23043

    authors: Eissa A,Wilman AH

    更新日期:2012-02-01 00:00:00

  • A new approach to Z-spectrum acquisition: prospective baseline enhancement (PROBE) for CEST/Nuclear Overhauser Effect.

    abstract:PURPOSE:To develop a prospective baseline enhancement that compensates for intermingled background effects in Z-spectra to achieve sensitivity enhancement of peaks related to CEST and nuclear Overhauser effect. METHODS:An MRI sequence-specific compensation of background effects is achieved through variation of the pul...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27555

    authors: Lenich T,Pampel A,Mildner T,Möller HE

    更新日期:2019-04-01 00:00:00

  • The MR tomograph as a sound generator: fMRI tool for the investigation of the auditory cortex.

    abstract::An automatic fMRI protocol for the investigation of the human auditory cortex has been developed. For the activation of the auditory system, the scanner noise itself is the source of sound. Rapid switching of B0 gradients allows the generation of tones of defined frequencies and amplitude on a conventional scanner wit...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910400621

    authors: Bilecen D,Radü EW,Scheffler K

    更新日期:1998-12-01 00:00:00

  • Vessel-specific quantification of blood oxygenation with T2-relaxation-under-phase-contrast MRI.

    abstract:PURPOSE:Measurement of venous oxygenation (Yv) is a critical step toward quantitative assessment of brain oxygen metabolism, a key index in many brain disorders. The present study aims to develop a noninvasive, rapid, and reproducible method to measure Yv in a vessel-specific manner. THEORY:The method, T2-Relaxation-U...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24750

    authors: Krishnamurthy LC,Liu P,Ge Y,Lu H

    更新日期:2014-03-01 00:00:00

  • Quantitative transport mapping (QTM) of the kidney with an approximate microvascular network.

    abstract:PURPOSE:Proof-of-concept study of mapping renal blood flow vector field according to the inverse solution to a mass transport model of time resolved tracer-labeled MRI data. THEORY AND METHODS:To determine tissue perfusion according to the underlying physics of spatiotemporal tracer concentration variation, the mass t...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28584

    authors: Zhou L,Zhang Q,Spincemaille P,Nguyen TD,Morgan J,Dai W,Li Y,Gupta A,Prince MR,Wang Y

    更新日期:2021-04-01 00:00:00

  • A 3 T sodium and proton composite array breast coil.

    abstract:PURPOSE:The objective of this study was to determine whether a sodium phased array would improve sodium breast MRI at 3 T. The secondary objective was to create acceptable proton images with the sodium phased array in place. METHODS:A novel composite array for combined proton/sodium 3 T breast MRI is compared with a c...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24860

    authors: Kaggie JD,Hadley JR,Badal J,Campbell JR,Park DJ,Parker DL,Morrell G,Newbould RD,Wood AF,Bangerter NK

    更新日期:2014-06-01 00:00:00

  • Proton high-resolution magic angle spinning NMR analysis of fresh and previously frozen tissue of human prostate.

    abstract::The previously observed improvement in spectral resolution of tissue proton NMR with high-resolution magic angle spinning (HRMAS) was speculated to be due largely to freeze-thawing artifacts resulting from tissue storage. In this study, 12 human prostate samples were analyzed on a 14.1T spectrometer at 3 degrees C, wi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10645

    authors: Wu CL,Taylor JL,He W,Zepeda AG,Halpern EF,Bielecki A,Gonzalez RG,Cheng LL

    更新日期:2003-12-01 00:00:00

  • Cooperative T1 and T2 effects on contrast using a new driven inversion spin-echo (DISE) MRI pulse sequence.

    abstract::A pulse sequence is presented for obtaining a single image with combined T1/T2 weighting. T2 relaxation is made to increase intensity, in cooperation with the effect of T1 relaxation, by providing T2 weighting with a 90 degrees-180 degrees-90 degrees driven inversion pulse triplet in an inversion recovery method. Unli...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910150307

    authors: Conturo TE,Kessler RM,Beth AH

    更新日期:1990-09-01 00:00:00